Treatment-resistant depression in adolescents: review and updates on clinical management.

Abstract:

:Treatment-resistant depression (TRD) in adolescents is prevalent and impairing. We here review the definition, prevalence, clinical significance, risk factors, and management of TRD in adolescents. Risk factors associated with TRD include characteristics of depression (severity, level of hopelessness, and suicidal ideation), psychiatric and medical comorbidities, environmental factors (family conflict, maternal depression, and history of abuse), and pharmacokinetics and other biomarkers. Management options include review of the adequacy of the initial treatment, re-assessment for the above-noted factors that might predispose to treatment resistance, switching antidepressants, and augmentation with medication or psychotherapy. Other modalities, such as electroconvulsive therapy, vagal nerve stimulation, and repetitive transcranial magnetic stimulation, are also reviewed.

journal_name

Depress Anxiety

journal_title

Depression and anxiety

authors

Maalouf FT,Atwi M,Brent DA

doi

10.1002/da.20884

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

946-54

issue

11

eissn

1091-4269

issn

1520-6394

journal_volume

28

pub_type

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