Abstract:
:Data from early studies of selective serotonin reuptake inhibitors have shown that these agents are effective in the treatment of social anxiety disorder (social phobia). This review highlights the outcomes of three large clinical trials of paroxetine in patients with social anxiety disorder. In two of the studies, patients received a flexible dose of paroxetine (20-50 mg/day) or placebo; the third trial was a fixed-dose study, in which patients received paroxetine 20, 40, or 60 mg/day, or placebo. A total of 861 subjects were randomized to treatment for 12 weeks, in centers across the U.S.A., Canada, Europe, and South Africa. The primary outcome measures were the Clinical Global Impressions (CGI) Global Improvement item and Liebowitz Social Anxiety Scale (LSAS) Total Score. In each of the studies, 45-66% of patients receiving paroxetine were rated as responders (very much or much improved on the CGI scale). Paroxetine treatment improved symptoms of social anxiety, as measured by the LSAS, compared with placebo. Differences between paroxetine and placebo groups were statistically significant and were clinically relevant within each study. In general, paroxetine was well tolerated. Paroxetine is effective for the treatment of social anxiety disorder. Based on the findings from these studies, a starting dose of 20 mg/day is recommended. The range of efficacy appears to be 20-50 mg/day for most patients.
journal_name
Depress Anxietyjournal_title
Depression and anxietyauthors
Lydiard RB,Bobes Jsubject
Has Abstractpub_date
2000-01-01 00:00:00pages
99-104issue
3eissn
1091-4269issn
1520-6394pii
10.1002/(SICI)1520-6394(2000)11:3<99::AID-DA3>3.0.journal_volume
11pub_type
杂志文章abstract:BACKGROUND:Dimensional assessments are planned to be included as supplements to categorical diagnoses in DSM-V. The aim of this study was to examine the unidimensionality, reliability, validity, and clinical sensitivity of brief self-rated scales for specific anxiety disorders in an unselected German sample of consecut...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.21994
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Recent research suggests that posttraumatic stress disorder (PTSD) is associated with altered amygdala and hippocampal resting-state functional connectivity (rsFC). However, less research has examined whether Prolonged Exposure (PE), a first line exposure-based treatment for PTSD, has the potential to alter ...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22816
更新日期:2018-10-01 00:00:00
abstract::The growing recognition and occurrence of traumatic exposure in the general population has given increased salience to the need to understand the concept of resilience. More than just the "flip side" of a risk factor, the notion of resilience encompasses psychological and biological characteristics, intrinsic to an in...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.20175
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:A pooled analysis was performed on data from two studies evaluating the efficacy of once-daily extended-release quetiapine fumarate (quetiapine XR) monotherapy for patients with major depressive disorder. Through these analyses (based on Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale ...
journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
doi:10.1002/da.21970
更新日期:2012-07-01 00:00:00
abstract::This study used an open clinical trial to test a cognitive-behavioral treatment for public-speaking anxiety that utilized virtual reality as a tool for exposure therapy. Treatment was completed by participants (n = 10) meeting the Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV criteria for social phobi...
journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章
doi:10.1002/da.20090
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Adolescent depression may increase risk for poor mental health outcomes in adulthood. The objective of this study was to systematically review the literature on the association between adolescent depression and adult anxiety and depressive disorders as well as suicidality. METHODS:EMBASE, MEDLINE, and PSYCi...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.22777
更新日期:2018-08-01 00:00:00
abstract::Clinical commentators widely interpret crying as a sign of depressed mood. However, there is virtually no empirical data on this topic, and the evidence that mood disorders alter crying is surprisingly weak. This study compared mood disordered patients to a nonpsychiatric reference group on the frequency, antecedents,...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20331
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Preliminary evidence suggests intravenous ketamine has rapid effects on suicidal cognition, making it an attractive candidate for depressed patients at imminent risk of suicide. In the first randomized controlled trial of ketamine using an anesthetic control condition, we tested ketamine's acute effects on e...
journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
doi:10.1002/da.22253
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:The clinical presentation of panic disorder (PD) is known to be highly heterogeneous, complicating research on its etiology, neurobiological pathways, and treatment. None of the attempts to identify PD subtypes have been independently reproduced, rendering the current literature inconclusive. METHODS:Using ...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22379
更新日期:2015-07-01 00:00:00
abstract::Our objective was to evaluate parental risk factors for pediatric-onset panic disorder/agoraphobia (PD/AG) in offspring at high risk for PD/AG. Comparisons were made between parents with PD who had a child with PD or AG (N = 27) and parents with PD without children with PD or AG (N = 79). Comparisons were also made be...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20122
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Childhood maltreatment has been associated with symptom severity, reduced quality of life, and impaired functioning in adults with social anxiety disorder (SAD). No study has investigated how childhood maltreatment impacts pharmacotherapy outcomes in this population, despite evidence for such a link in depre...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20909
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Brain structures underlying posttraumatic stress disorder (PTSD) have been a focus of imaging studies, but associations between treatment outcome and alterations in brain structures remain largely unexamined. We longitudinally examined the relation of structural changes in the rostral anterior cingulate cort...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22471
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Individuals with depression may not seek treatment for their symptoms due to several types of barriers to treatment. In support of the growing research on mental health care access and the role of social media, this study aimed to increase knowledge of these barriers among social media users. METHODS:Partic...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22990
更新日期:2020-05-01 00:00:00
abstract::There are no reports of a child taking a selective serotonin reuptake inhibitor and an atypical anti-psychotic being successfully tapered from these medications after completion of cognitive-behavioral therapy (CBT) for obsessive-compulsive disorder. With this in mind, we report the case of an 8.5-year-old male who wa...
journal_title:Depression and anxiety
pub_type: 信件
doi:10.1002/da.20448
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:To examine the potential mediating role of parenting behaviors in the longitudinal, bidirectional relationships between maternal depression and child internalizing symptoms (i.e. depression and anxiety). METHODS:We analyzed data from 4,581 mother-child dyads from the Fragile Families and Child Wellbeing Stu...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22688
更新日期:2018-01-01 00:00:00
abstract::Serotonergic (5-hydroxytryptamine; 5-HT) mechanisms have been implicated in a number of physiological and pathophysiological processes including mood, anxiety, and cognitive functioning. Among the many 5-HT receptor subtypes, the 5-HT2A receptors (5-HT2A-R) seem to be of particular importance in mediating these effect...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20087
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Actigraphy may provide a more valid assessment of sleep, circadian rhythm (CR), and physical activity (PA) than self-reported questionnaires, but has not been used widely to study the association with depression/anxiety and their clinical characteristics. METHODS:Fourteen-day actigraphy data of 359 particip...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22949
更新日期:2019-10-01 00:00:00
abstract::We examined the personality characteristics of depressed patients with and without atypical depression. Of 195 depressed outpatients in a randomized treatment trial of fluoxetine or nortriptyline, 16 met DSM-IV criteria for atypical depression. We compared the personality traits and disorders in those with and without...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20001
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Women are at an increased risk of depression and other mental health problems following rape. Various etiological factors for depression, including predisposing genetic factors, have been identified. Telomeres are repetitive nucleoprotein structures located at chromosomal ends that protect them from prematur...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20903
更新日期:2011-12-21 00:00:00
abstract::The chronicity and morbidity of established post-traumatic stress disorder (PTSD) has stimulated interest in recognizing and understanding the early development of the disorder. Acute stress disorder, a new diagnosis intended to facilitate early case detection, rests on the occurrence of dissociative reactions. It rem...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.1071
更新日期:2001-01-01 00:00:00
abstract::Given the high rates of maladjustment among children of depressed mothers, parenting is likely to cause significant life stress in this population, potentially worsening the course of mothers' depression. The present study is a comparison of severe life stress in 38 mothers and 62 non-mothers receiving treatment for r...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.1026
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Major depressive disorder (MDD) and smoking are major public health problems and epidemiologically strongly associated. However, the relationship between smoking and depression and whether this is influenced by common confounding factors remain unclear, in part due to limited longitudinal data on covariation...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22108
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Controversy surrounds the question of whether agoraphobia (AG) exists as an independent diagnostic entity apart from panic. In favor of this position, AG without panic disorder (PD) in parents was found being unrelated to offsprings' risk for AG or PD, albeit it may enhance the familial transmission of PD (N...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.21975
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:The present trial was designed to assess the efficacy and safety of escitalopram prescribed to patients seeking treatment of major depressive disorder (MDD) in a Canadian primary-care setting. METHODS:Investigators (mainly primary-care physicians) enrolled patients with MDD from their daily practice. Patien...
journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/da.20458
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:In this randomized controlled trial, cognitive-behavioral group therapy (CBGT) for social anxiety disorder (SAD) was compared to group psychotherapy (GPT), a credible, structurally equivalent control condition that included only nonspecific factors of group treatment (such as group dynamics). METHODS:Partici...
journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
doi:10.1002/da.20877
更新日期:2011-11-01 00:00:00
abstract::This study assessed striatal dopamine 1 (D1) receptor binding in patients with major depressive disorder and anger attacks (MDD+A) and healthy volunteers. We used positron emission tomography with [(11)C]SCH 23,390 to compare 10 patients with MDD+A to 10 healthy volunteers. [(11)C]SCH 23,390 binding in bilateral stria...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20168
更新日期:2006-01-01 00:00:00
abstract::Treatment-resistant depression (TRD) in adolescents is prevalent and impairing. We here review the definition, prevalence, clinical significance, risk factors, and management of TRD in adolescents. Risk factors associated with TRD include characteristics of depression (severity, level of hopelessness, and suicidal ide...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.20884
更新日期:2011-11-01 00:00:00
abstract::Electroconvulsive therapy (ECT) involves the use of electrical stimulation to elicit a series of generalized tonic-clonic seizures for therapeutic purposes and is the most effective treatment known for major depression. These treatments have significant neurophysiologic effects, many of which are manifest in the elect...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/1520-6394(2000)12:3<157::AID-DA7>3.0.CO;2-
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Depression and anxiety have been related to poorer self-reported physical functioning over time; however, objective measures of physical function are less frequently examined. This study assessed the 6-year trajectory of hand-grip strength and lung function in persons with depressive and/or anxiety disorders...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22557
更新日期:2017-02-01 00:00:00
abstract::This multicenter study estimated the prevalence of major depressive disorder (MDD) among emergency department patients in Latin America. To identify patients with MDD, we used a combination of DSM IV- criteria interview and a questionnaire screen including the center for Epidemiological Studies Depression Scale. We an...
journal_title:Depression and anxiety
pub_type: 杂志文章,多中心研究
doi:10.1002/da.20380
更新日期:2008-01-01 00:00:00