Cytokine targets in the brain: impact on neurotransmitters and neurocircuits.

abstract：BACKGROUND:Neural activity is increasingly used in addition to behavioral measures to study anxiety and attentional biases toward threatening stimuli. Event-related potentials (ERPs) might be particularly useful because of their excellent temporal resolution. In particular, the late positive potential (LPP) reflects in...

journal_title：Depression and anxiety

authors： MacNamara A,Hajcak G

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Previous work has shown that inhibition of fear is impaired in posttraumatic stress disorder (PTSD) resulting from both civilian and combat trauma. The purpose of the present study was to investigate the inhibition of learned fear in traumatized individuals diagnosed with either acute stress disorder (ASD) o...

journal_title：Depression and anxiety

authors： Jovanovic T,Sakoman AJ,Kozarić-Kovačić D,Meštrović AH,Duncan EJ,Davis M,Norrholm SD

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Fear overgeneralization is a central feature of anxiety disorders and can lead to excessive avoidance. As perceptual discrimination is a key component of fear overgeneralization, a perceptual discrimination training task was created aimed at improving perceptual discrimination and reducing fear overgeneraliz...

journal_title：Depression and anxiety

authors： Ginat-Frolich R,Klein Z,Aderka IM,Shechner T

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:To elucidate mechanisms related to remission in winter seasonal affective disorder (SAD), we explored the course of individual depressive symptom offset across two distinct treatment modalities that show comparable outcomes at treatment endpoint: cognitive-behavioral therapy for SAD (CBT-SAD) and light thera...

journal_title：Depression and anxiety

authors： Meyerhoff J,Young MA,Rohan KJ

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Increased psychophysiological reactivity is a hallmark intermediate phenotype of posttraumatic stress disorder (PTSD). Individuals with PTSD exhibit greater skin conductance (SC) responses to trauma scripts than trauma survivors without PTSD. However, trauma scripts require time for development and cannot be...

journal_title：Depression and anxiety

authors： Hinrichs R,Michopoulos V,Winters S,Rothbaum AO,Rothbaum BO,Ressler KJ,Jovanovic T

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:The clinical presentation of panic disorder (PD) is known to be highly heterogeneous, complicating research on its etiology, neurobiological pathways, and treatment. None of the attempts to identify PD subtypes have been independently reproduced, rendering the current literature inconclusive. METHODS:Using ...

journal_title：Depression and anxiety

authors： Pattyn T,Van Den Eede F,Lamers F,Veltman D,Sabbe BG,Penninx BW

更新日期：2015-07-01 00:00:00

abstract：:A reclassification of obsessive-compulsive disorder (OCD) into a new diagnostic category spectrum of "obsessive-compulsive spectrum disorders" (OCSDs) has recently been proposed, with considerable debate, for the forthcoming Diagnostic and Statistical Manual-Fifth Edition (DSM-V). This paper provides a critical analys...

journal_title：Depression and anxiety

authors： Storch EA,Abramowitz J,Goodman WK

更新日期：2008-01-01 00:00:00

abstract：:Participants with generalized social phobia (GSP) with (n=36) and without (n=19) avoidant personality disorder (AVPD) were compared via contrasts of group means and classification analysis on purported core features of AVPD. GSP-AVPD participants proved to be more severely impaired or distressed on some group contrast...

journal_title：Depression and anxiety

authors： Chambless DL,Fydrich T,Rodebaugh TL

更新日期：2008-01-01 00:00:00

abstract：:In this analysis we examined studies of tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) to compare efficacy and drop-out rates. Frequency of reported side effects was also studied. Using Medline, we located 36 clinical trials of TCAs and SSRIs in a double-blind comparison. We perfo...

journal_title：Depression and anxiety

authors： Steffens DC,Krishnan KR,Helms MJ

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Investigations of gene-environment interaction (GxE) in depression have implicated a polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) as a moderator of the stress-depression relationship. However, recent evidence for 5-HTTLPR GxE in depression has been inconsistent. This study...

journal_title：Depression and anxiety

authors： Conway CC,Hammen C,Brennan PA,Lind PA,Najman JM

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Collectively, functional neuroimaging studies implicate frontal-limbic dysfunction in the pathophysiology of posttraumatic stress disorder (PTSD), as reflected by altered amygdala reactivity and deficient prefrontal responses. These neural patterns are often elicited by social signals of threat (fearful/angr...

journal_title：Depression and anxiety

authors： Rabinak CA,MacNamara A,Kennedy AE,Angstadt M,Stein MB,Liberzon I,Phan KL

更新日期：2014-10-01 00:00:00

abstract：:Our objective was to evaluate parental risk factors for pediatric-onset panic disorder/agoraphobia (PD/AG) in offspring at high risk for PD/AG. Comparisons were made between parents with PD who had a child with PD or AG (N = 27) and parents with PD without children with PD or AG (N = 79). Comparisons were also made be...

journal_title：Depression and anxiety

authors： Biederman J,Petty C,Faraone SV,Hirshfeld-Becker DR,Henin A,Dougherty M,Lebel TJ,Pollack M,Rosenbaum JF

更新日期：2005-01-01 00:00:00

abstract：:Placebo-controlled trials have evaluated the efficacy of several medications in the treatment of social anxiety disorder but information regarding their relative efficacy is lacking. We compared the efficacy of medications systematically studied for the treatment of social anxiety disorder using meta-analytic techniqu...

journal_title：Depression and anxiety

authors： Blanco C,Schneier FR,Schmidt A,Blanco-Jerez CR,Marshall RD,Sánchez-Lacay A,Liebowitz MR

更新日期：2003-01-01 00:00:00

abstract：:Pediatric psychopharmacology is hindered by the relative lack of controlled, empirical clinical trials [Shatzberg and Nemeroff, 1998: Washington, D.C.: The American Psychiatric Press, Inc. p 301-306]. Psychiatric disorders in children and adolescents carry considerable morbidity, impede development, and carry a signif...

journal_title：Depression and anxiety

authors： Weller EB,Weller RA,Davis GP

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:To examine the potential mediating role of parenting behaviors in the longitudinal, bidirectional relationships between maternal depression and child internalizing symptoms (i.e. depression and anxiety). METHODS:We analyzed data from 4,581 mother-child dyads from the Fragile Families and Child Wellbeing Stu...

journal_title：Depression and anxiety

authors： Kuckertz JM,Mitchell C,Wiggins JL

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:There is evidence that negative affect (NA) and anxiety sensitivity (AS) predict the development of anxiety disorders, particularly panic disorder (PD). The main purpose of this study was to examine whether NA and AS will also predict the clinical course of PD. METHODS:Participants were 136 individuals with...

journal_title：Depression and anxiety

authors： Benítez CI,Shea MT,Raffa S,Rende R,Dyck IR,Ramsawh HJ,Edelen MO,Keller MB

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Although numerous studies have examined the role of latent predispositions to internalizing and externalizing disorders in the structure of comorbidity among common mental disorders, none examined latent predispositions in predicting development of comorbidity. METHODS:A novel method was used to study the r...

journal_title：Depression and anxiety

authors： Kessler RC,Cox BJ,Green JG,Ormel J,McLaughlin KA,Merikangas KR,Petukhova M,Pine DS,Russo LJ,Swendsen J,Wittchen HU,Zaslavsky AM

更新日期：2011-01-01 00:00:00

abstract：:The purpose of this study was to correlate subjective sleep characteristics based on questionnaire response, and objective sleep EEG features based on polysomnography, in 52 patients with major depressive disorders (MDD) and 49 healthy controls. With the exception of the number of awakenings, subjective and objective ...

journal_title：Depression and anxiety

authors： Armitage R,Trivedi M,Hoffmann R,Rush AJ

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Evidence-based treatments for post-traumatic stress disorder (PTSD) have poor uptake and remission rates, suggesting that alternative treatments are needed. Morning bright light may be an effective treatment for PTSD given its established effects on mood and sleep, however, there are no published trials. ME...

journal_title：Depression and anxiety

authors： Zalta AK,Bravo K,Valdespino-Hayden Z,Pollack MH,Burgess HJ

更新日期：2019-07-01 00:00:00

abstract：:This report describes the reactivation of a posttraumatic stress disorder (PTSD) after a minor head injury in two young women who had recovered from extreme stress caused by sexual abuse during adolescence. Intrusive thoughts, images, dreams, and phobic avoidance bear a direct relationship to the specific circumstance...

journal_title：Depression and anxiety

authors： Berthier ML,Kulisevsky J,Fernández Benitez JA,Gironell A

更新日期：1998-01-01 00:00:00

abstract：:The increased risk of physical health problems in adult depressed patients has been shown in numerous studies. A recent study of the offspring of depressed parents found similar associations. The purpose of this study is to examine the strength and specificity of the association between depression and physical health ...

journal_title：Depression and anxiety

authors： McAvay G,Nunes EV,Zaider TI,Goldstein RB,Weissman MM

更新日期：1999-01-01 00:00:00

abstract：:This study examined the differences of heart rate variability measures between children of parents with panic disorder and children of healthy controls using linear as well as nonlinear techniques. Supine and standing heart rate variability indices were measured in all children using power spectral analysis and a meas...

journal_title：Depression and anxiety

authors： Srinivasan K,Ashok MV,Vaz M,Yeragani VK

更新日期：2002-01-01 00:00:00

abstract：:This study seeks to determine how panic disorder patients with anxiety and depression comorbidity differ from panic disorder patients without comorbidity at the time of presentation for treatment. One-hundred seventy-one panic disorder patients presenting for their initial assessment and treatment at the Payne Whitney...

journal_title：Depression and anxiety

authors： Apfeldorf WJ,Spielman LA,Cloitre M,Heckelman L,Shear MK

更新日期：2000-01-01 00:00:00

abstract：:Sleep deprivation for one night has been investigated as a treatment for depression since the first publications describing its antidepressant properties almost 30 years ago [Pflug and Tolle, 1971: Int Pharmacopsychiatry 6:187-196]. It remains a field of active research. It is the only intervention consistently demons...

journal_title：Depression and anxiety

authors： Ringel BL,Szuba MP

更新日期：2001-01-01 00:00:00

abstract：:Research has shown that obsessive compulsive disorder (OCD) is related to structural and functional abnormalities in the brain, and several authors have organized these findings into theories of OCD neuropsychiatric dysfunction. In this paper, these theories were used to develop a neural network model of OCD. OCD symp...

journal_title：Depression and anxiety

authors： Ownby RL

更新日期：1998-01-01 00:00:00

abstract：:The growing recognition and occurrence of traumatic exposure in the general population has given increased salience to the need to understand the concept of resilience. More than just the "flip side" of a risk factor, the notion of resilience encompasses psychological and biological characteristics, intrinsic to an in...

journal_title：Depression and anxiety

authors： Hoge EA,Austin ED,Pollack MH

更新日期：2007-01-01 00:00:00

abstract：:Reports on the severity and reversibility of cognitive disturbances in major depression in the literature diverge due to methodological biases. The present study, using a precise methodology, examined attention and executive functions in 20 relatively young, depressed patients presenting a first or second episode of u...

journal_title：Depression and anxiety

authors： Constant EL,Adam S,Gillain B,Seron X,Bruyer R,Seghers A

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Childhood maltreatment has been associated with symptom severity, reduced quality of life, and impaired functioning in adults with social anxiety disorder (SAD). No study has investigated how childhood maltreatment impacts pharmacotherapy outcomes in this population, despite evidence for such a link in depre...

journal_title：Depression and anxiety

authors： Bruce LC,Heimberg RG,Blanco C,Schneier FR,Liebowitz MR

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Maintenance of gains with cognitive-behavioral treatment for trichotillomania (TTM) has historically been problematic. METHODS:We conducted follow-up assessments 3 and 6 months after completion of a 3-month maintenance phase on 10 individuals with DSM-IV-TR TTM who participated in an open trial of a dialect...

journal_title：Depression and anxiety

authors： Keuthen NJ,Rothbaum BO,Falkenstein MJ,Meunier S,Timpano KR,Jenike MA,Welch SS

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Major depressive disorder (MDD) has been associated with changes in mean telomere length and mitochondrial DNA (mtDNA) copy number. This study investigates if clinical features of MDD differentially impact these molecular markers. METHODS:Data from a large, clinically ascertained sample of Han Chinese women...

journal_title：Depression and anxiety

authors： Edwards AC,Aggen SH,Cai N,Bigdeli TB,Peterson RE,Docherty AR,Webb BT,Bacanu SA,Flint J,Kendler KS

更新日期：2016-11-01 00:00:00