Parental predictors of pediatric panic disorder/agoraphobia: a controlled study in high-risk offspring.


:Our objective was to evaluate parental risk factors for pediatric-onset panic disorder/agoraphobia (PD/AG) in offspring at high risk for PD/AG. Comparisons were made between parents with PD who had a child with PD or AG (N = 27) and parents with PD without children with PD or AG (N = 79). Comparisons were also made between the spouses of these parents with PD. Separation anxiety disorder, social phobia, obsessive-compulsive disorder, and bipolar disorder in the parents with PD and their spouses accounted for the risk for childhood onset PD/AG in the offspring. This risk was particularly high if both parents were affected with social phobia. These findings suggest that psychiatric comorbidity with other anxiety disorders and with bipolar disorder in parents with PD and their spouses confer a particularly high risk in their offspring to develop PD/AG in childhood.


Depress Anxiety


Depression and anxiety


Biederman J,Petty C,Faraone SV,Hirshfeld-Becker DR,Henin A,Dougherty M,Lebel TJ,Pollack M,Rosenbaum JF




Has Abstract


2005-01-01 00:00:00












  • Possible precipitants of psychiatric hospitalization in patients with major depression: results from the Jerusalem Collaborative Depression Project.

    abstract::In spite of substantial advances in the treatment of major depression by pharmacotherapy and other means, a significant number of depressed patients require hospitalization. In the context of the Jerusalem Collaborative Depression Project, possible precipitants of psychiatric hospitalization were sought in a cohort of...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Lerer B,Shapira B,Bloch M,Hanin B,Trudart T,Alexander JR,Popper M,Braun D,Segman RH,Ritsner M

    更新日期:1999-01-01 00:00:00

  • The role of comorbid anxiety in exercise and depression trials: Secondary analysis of the SMILE-II randomized clinical trial.

    abstract:OBJECTIVES:To explore the anxiolytic effects of a 4-month randomized, placebo-controlled trial of exercise and antidepressant medication in patients with major depressive disorder (MDD), and to examine the potential modifying effects of anxiety in treating depressive symptoms. MATERIALS AND METHODS:In this secondary a...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Blumenthal JA,Babyak MA,Craighead WE,Davidson J,Hinderliter A,Hoffman B,Doraiswamy PM,Sherwood A

    更新日期:2020-08-12 00:00:00

  • Childhood maltreatment and social anxiety disorder: implications for symptom severity and response to pharmacotherapy.

    abstract:BACKGROUND:Childhood maltreatment has been associated with symptom severity, reduced quality of life, and impaired functioning in adults with social anxiety disorder (SAD). No study has investigated how childhood maltreatment impacts pharmacotherapy outcomes in this population, despite evidence for such a link in depre...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Bruce LC,Heimberg RG,Blanco C,Schneier FR,Liebowitz MR

    更新日期:2012-02-01 00:00:00

  • Amygdala-Cortical Connectivity: Associations with Anxiety, Development, and Threat.

    abstract:BACKGROUND:Amygdala-prefrontal cortex (PFC) functional connectivity may be influenced by anxiety and development. A prior study on anxiety found age-specific dysfunction in the ventromedial PFC (vmPFC), but not amygdala, associated with threat-safety discrimination during extinction recall (Britton et al.). However, tr...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Gold AL,Shechner T,Farber MJ,Spiro CN,Leibenluft E,Pine DS,Britton JC

    更新日期:2016-10-01 00:00:00

  • The role of values-consistent behavior in generalized anxiety disorder.

    abstract:BACKGROUND:Theory and research suggest that generalized anxiety disorder (GAD) is associated with diminished quality of life and restriction in valued action. The purpose of this study was to examine the relevance of values-consistent behavior (valued action) in understanding the impairment in quality of life in GAD. ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Michelson SE,Lee JK,Orsillo SM,Roemer L

    更新日期:2011-05-01 00:00:00

  • Cognitive behavioral therapy for public-speaking anxiety using virtual reality for exposure.

    abstract::This study used an open clinical trial to test a cognitive-behavioral treatment for public-speaking anxiety that utilized virtual reality as a tool for exposure therapy. Treatment was completed by participants (n = 10) meeting the Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV criteria for social phobi...

    journal_title:Depression and anxiety

    pub_type: 临床试验,杂志文章


    authors: Anderson PL,Zimand E,Hodges LF,Rothbaum BO

    更新日期:2005-01-01 00:00:00

  • Morbidity of comorbid psychiatric diagnoses in the clinical presentation of panic disorder.

    abstract::This study seeks to determine how panic disorder patients with anxiety and depression comorbidity differ from panic disorder patients without comorbidity at the time of presentation for treatment. One-hundred seventy-one panic disorder patients presenting for their initial assessment and treatment at the Payne Whitney...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Apfeldorf WJ,Spielman LA,Cloitre M,Heckelman L,Shear MK

    更新日期:2000-01-01 00:00:00

  • Morphometric alterations of anterior superior temporal cortex in obsessive-compulsive disorder.

    abstract::The superior temporal gyrus (STG) may be involved in the pathophysiology of obsessive-compulsive disorder (OCD). Moreover, the anterior STG has rich interconnections with the orbitofrontal cortex and the amygdala, and plays a role in visuospatial processing, which is impaired in patients with OCD. This study was desig...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Choi JS,Kim HS,Yoo SY,Ha TH,Chang JH,Kim YY,Shin YW,Kwon JS

    更新日期:2006-01-01 00:00:00

  • Relationship between ADIS clinician's severity rating and self-report measures among social phobics.

    abstract::Although global clinical rating scales have been a mainstay of clinical research, little is known about the relationship between these measures and other assessment modalities. The present study examined the Clinician's Severity Rating (CSR) from the Anxiety Disorders Interview Schedule in a sample of 186 social phobi...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Hope DA,Laguna LB,Heimberg RG,Barlow DH

    更新日期:1996-01-01 00:00:00

  • Are obsessive-compulsive symptom dimensions familial in nonclinical individuals?

    abstract:BACKGROUND:Obsessive-compulsive disorder (OCD) is a heterogeneous condition, which can be expressed as various potentially overlapping symptom dimensions. In clinical samples, some of these dimensions are associated with increased familial risk for OCD and appear to be familial (intercorrelated within pairs of affected...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Taberner J,Fullana MA,Caseras X,Pertusa A,Bados A,van den Bree M,Torrubia R,Mataix-Cols D

    更新日期:2009-01-01 00:00:00

  • Periloss dissociation, symptom severity, and treatment response in complicated grief.

    abstract:BACKGROUND:Complicated grief (CG) is a bereavement-specific syndrome characterized by traumatic and separation distress lasting over 6 months. Little is known about the role of dissociation experienced during or immediately after the loss of a loved one (i.e., periloss dissociation [PLD]) in CG. The present study aimed...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验


    authors: Bui E,Simon NM,Robinaugh DJ,Leblanc NJ,Wang Y,Skritskaya NA,Mauro C,Shear MK

    更新日期:2013-02-01 00:00:00

  • A three-year follow-up of major depression, dysthymia, minor depression and subsyndromal depression: results from a population-based study.

    abstract::This study examined the 3-year outcome of major depression (MD)/dysthymic disorder (DD), minor depression (MinD), and subsyndromal symptomatic depression (SSD) in a population-based sample. The aims were to study the fluctuating nature of the symptoms of depression and to analyze the risk of fulfilling the criteria fo...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Forsell Y

    更新日期:2007-01-01 00:00:00

  • Amygdala activation in response to facial expressions in pediatric obsessive-compulsive disorder.

    abstract:BACKGROUND:Exaggerated amygdala activation to threatening faces has been detected in adults and children with anxiety disorders, compared to healthy comparison (HC) subjects. However, the profile of amygdala activation in response to facial expressions in obsessive-compulsive disorder (OCD) may be a distinguishing feat...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Britton JC,Stewart SE,Killgore WD,Rosso IM,Price LM,Gold AL,Pine DS,Wilhelm S,Jenike MA,Rauch SL

    更新日期:2010-07-01 00:00:00

  • Trajectories of childhood adversity and the risk of depression in young adulthood: Results from the Avon Longitudinal Study of Parents and Children.

    abstract:BACKGROUND:The significance of the timing and chronicity of childhood adversity for depression outcomes later in life is unclear. Identifying trajectories of adversity throughout childhood would allow classification of children according to the accumulation, timing, and persistence of adversity, and may provide unique ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Tracy M,Salo M,Slopen N,Udo T,Appleton AA

    更新日期:2019-07-01 00:00:00

  • Fluoxetine in child and adolescent depression: acute and maintenance treatment.

    abstract::The objective was to present naturalistic 1-year follow-up information of 96 child and adolescent outpatients with major depressive disorder who had been randomized in an 8-week double-blind, placebo-controlled trial of fluoxetine. Subjects were children and adolescents, ages 8-18 years, who were entered in a randomiz...

    journal_title:Depression and anxiety

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Emslie GJ,Rush AJ,Weinberg WA,Kowatch RA,Carmody T,Mayes TL

    更新日期:1998-01-01 00:00:00


    abstract:BACKGROUND:Diagnostic criteria for DSM-5 posttraumatic stress disorder (PTSD) are in many ways similar to DSM-IV criteria, raising the possibility that it might be possible to closely approximate DSM-5 diagnoses using DSM-IV symptoms. If so, the resulting transformation rules could be used to pool research data based o...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Rosellini AJ,Stein MB,Colpe LJ,Heeringa SG,Petukhova MV,Sampson NA,Schoenbaum M,Ursano RJ,Kessler RC,Army STARRS Collaborators.

    更新日期:2015-07-01 00:00:00

  • Cognitive-behavioral group therapy versus group psychotherapy for social anxiety disorder among college students: a randomized controlled trial.

    abstract:OBJECTIVE:In this randomized controlled trial, cognitive-behavioral group therapy (CBGT) for social anxiety disorder (SAD) was compared to group psychotherapy (GPT), a credible, structurally equivalent control condition that included only nonspecific factors of group treatment (such as group dynamics). METHODS:Partici...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验


    authors: Bjornsson AS,Bidwell LC,Brosse AL,Carey G,Hauser M,Mackiewicz Seghete KL,Schulz-Heik RJ,Weatherley D,Erwin BA,Craighead WE

    更新日期:2011-11-01 00:00:00

  • Subthreshold PTSD and PTSD in a prospective-longitudinal cohort of military personnel: Potential targets for preventive interventions.

    abstract:BACKGROUND:Prevention of PTSD requires identification of subpopulations contributing most to the population burden of PTSD. This study examines the relative contribution of subthreshold PTSD and probable PTSD on future PTSD in a representative military cohort. METHODS:We analyze data on 3,457 U.S. National Guard membe...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Fink DS,Gradus JL,Keyes KM,Calabrese JR,Liberzon I,Tamburrino MB,Cohen GH,Sampson L,Galea S

    更新日期:2018-11-01 00:00:00

  • Psychodynamic psychotherapy versus cognitive behavior therapy for social anxiety disorder: an efficacy and partial effectiveness trial.

    abstract:OBJECTIVES:Comparing the overall and differential effects of psychodynamic psychotherapy (PDT) versus cognitive behavior therapy (CBT) for social anxiety disorder (SAD). DESIGN:Patients with a primary SAD (N = 47) were randomly assigned to PDT (N = 22) or CBT (N = 27). Both PDT and CBT consisted of up to 36 sessions (...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验


    authors: Bögels SM,Wijts P,Oort FJ,Sallaerts SJ

    更新日期:2014-05-01 00:00:00

  • Employer burden of mild, moderate, and severe major depressive disorder: mental health services utilization and costs, and work performance.

    abstract:BACKGROUND:Treatment utilization/costs and work performance for persons with major depressive disorder (MDD) by severity of illness is not well documented. METHODS:Using National Comorbidity Survey-Replication (2001-2002) data, US workforce respondents (n=4,465) were classified by clinical severity (not clinically dep...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Birnbaum HG,Kessler RC,Kelley D,Ben-Hamadi R,Joish VN,Greenberg PE

    更新日期:2010-01-01 00:00:00

  • Endogenous oxytocin is associated with the experience of compassion and recalled upbringing in Borderline Personality Disorder.

    abstract:BACKGROUND/OBJECTIVE:The role of the neuropeptide oxytocin (OT) in Borderline Personality Disorder (BPD) is poorly understood. It is particularly unknown how early experiences with caregivers moderate the action of OT in BPD. Here, we examined the association of plasma OT levels in BPD patients with the experience of c...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Ebert A,Edel MA,Gilbert P,Brüne M

    更新日期:2018-01-01 00:00:00

  • Measurement invariance of the patient health questionnaire-9 (PHQ-9) depression screener in U.S. adults across sex, race/ethnicity, and education level: NHANES 2005-2016.

    abstract:BACKGROUND:Despite its popularity, little is known about the measurement invariance of the Patient Health Questionnaire-9 (PHQ-9) across U.S. sociodemographic groups. Use of a screener shown not to possess measurement invariance could result in under/over-detection of depression, potentially exacerbating sociodemograph...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Patel JS,Oh Y,Rand KL,Wu W,Cyders MA,Kroenke K,Stewart JC

    更新日期:2019-09-01 00:00:00

  • RGS2 and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults.

    abstract:BACKGROUND:Generalized anxiety disorder (GAD) is a common and sometimes disabling condition often associated with stressful life events that involve significant loss or danger. The disorder appears moderately heritable. Polymorphisms in the RGS2 (regulator of G-protein signaling 2) gene were recently associated with an...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Koenen KC,Amstadter AB,Ruggiero KJ,Acierno R,Galea S,Kilpatrick DG,Gelernter J

    更新日期:2009-01-01 00:00:00

  • Decreased striatal D1 binding as measured using PET and [11C]SCH 23,390 in patients with major depression with anger attacks.

    abstract::This study assessed striatal dopamine 1 (D1) receptor binding in patients with major depressive disorder and anger attacks (MDD+A) and healthy volunteers. We used positron emission tomography with [(11)C]SCH 23,390 to compare 10 patients with MDD+A to 10 healthy volunteers. [(11)C]SCH 23,390 binding in bilateral stria...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Dougherty DD,Bonab AA,Ottowitz WE,Livni E,Alpert NM,Rauch SL,Fava M,Fischman AJ

    更新日期:2006-01-01 00:00:00

  • Smoking and suicidality in subjects with bipolar disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC).

    abstract:BACKGROUND:Smoking in patients with bipolar disorder is known to be related to suicidality. This link has not been investigated, however, in community-based samples. The aim of this study is to delineate the sociodemographic and clinical characteristics of bipolar smokers and examine the relationship between these char...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Baek JH,Eisner LR,Nierenberg AA

    更新日期:2013-10-01 00:00:00

  • Shame, personality, and social anxiety symptoms in Chinese and American nonclinical samples: a cross-cultural study.

    abstract::Shame has been observed to play an important role in social anxiety in China [Xu, 1982]. Shame and personality factors, such as neuroticism and introversion-extraversion, are also related to social anxiety symptoms in Chinese college students [Li et al., 2003]. The aim of this study was to explore cross-cultural diffe...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Zhong J,Wang A,Qian M,Zhang L,Gao J,Yang J,Li B,Chen P

    更新日期:2008-01-01 00:00:00

  • Psychological resilience in older U.S. veterans: results from the national health and resilience in veterans study.

    abstract:BACKGROUND:Although a large body of empirical research has examined negative psychological outcomes in older veterans, relatively little is known about the prevalence and determinants of psychological resilience in this population. METHODS:A nationally representative sample of 2,025 U.S. veterans aged 60 and older (me...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Pietrzak RH,Cook JM

    更新日期:2013-05-01 00:00:00

  • Extended release quetiapine fumarate in major depressive disorder: analysis in patients with anxious depression.

    abstract:BACKGROUND:A pooled analysis was performed on data from two studies evaluating the efficacy of once-daily extended-release quetiapine fumarate (quetiapine XR) monotherapy for patients with major depressive disorder. Through these analyses (based on Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验


    authors: Thase ME,Demyttenaere K,Earley WR,Gustafsson U,Udd M,Eriksson H

    更新日期:2012-07-01 00:00:00

  • Less is more: Patient-level meta-analysis reveals paradoxical dose-response effects of a computer-based social anxiety intervention targeting attentional bias.

    abstract:BACKGROUND:The past decade of research has seen considerable interest in computer-based approaches designed to directly target cognitive mechanisms of anxiety, such as attention bias modification (ABM). METHODS:By pooling patient-level datasets from randomized controlled trials of ABM that utilized a dot-probe trainin...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,meta分析,评审


    authors: Price RB,Kuckertz JM,Amir N,Bar-Haim Y,Carlbring P,Wallace ML

    更新日期:2017-12-01 00:00:00

  • Evidence-based psychotherapy trends among posttraumatic stress disorder patients in a national healthcare system, 2001-2014.

    abstract:BACKGROUND:Although evidence-based psychotherapies (EBPs) for posttraumatic stress disorder (PTSD) were implemented starting in 2005 in the veterans health administration (VHA), the largest national healthcare system in the U.S., the rate of initiation (uptake) and prevalence of these treatments in each calendar year h...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Maguen S,Holder N,Madden E,Li Y,Seal KH,Neylan TC,Lujan C,Patterson OV,DuVall SL,Shiner B

    更新日期:2020-04-01 00:00:00