Abstract:
BACKGROUND:Exaggerated amygdala activation to threatening faces has been detected in adults and children with anxiety disorders, compared to healthy comparison (HC) subjects. However, the profile of amygdala activation in response to facial expressions in obsessive-compulsive disorder (OCD) may be a distinguishing feature; a prior study found that compared with healthy adults, adults with OCD exhibited less amygdala activation to emotional and neutral faces, relative to fixation [Cannistraro et al. (2004). Biological Psychiatry 56:916-920]. METHODS:In the current event-related functional magnetic resonance imaging (fMRI) study, a pediatric OCD sample (N=12) and a HC sample (N=17) performed a gender discrimination task while viewing emotional faces (happy, fearful, disgusted) and neutral faces. RESULTS:Compared to the HC group, the OCD group showed less amygdala/hippocampus activation in all emotion and neutral conditions relative to fixation. CONCLUSIONS:Like previous reports in adult OCD, pediatric OCD may have a distinct neural profile from other anxiety disorders, with respect to amygdala activation in response to emotional stimuli that are not disorder specific.
journal_name
Depress Anxietyjournal_title
Depression and anxietyauthors
Britton JC,Stewart SE,Killgore WD,Rosso IM,Price LM,Gold AL,Pine DS,Wilhelm S,Jenike MA,Rauch SLdoi
10.1002/da.20718subject
Has Abstractpub_date
2010-07-01 00:00:00pages
643-51issue
7eissn
1091-4269issn
1520-6394journal_volume
27pub_type
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