Abstract:
BACKGROUND:Adolescent depression may increase risk for poor mental health outcomes in adulthood. The objective of this study was to systematically review the literature on the association between adolescent depression and adult anxiety and depressive disorders as well as suicidality. METHODS:EMBASE, MEDLINE, and PSYCinfo databases were searched and longitudinal cohort studies in which depression was measured in adolescence (age 10-19) and outcomes of depressive disorders, anxiety disorders, or suicidality were measured in adulthood (age 21+), were selected. Meta-analysis using inverse variance and random effects modeling, along with sensitivity analyses, were used to synthesize article estimates. RESULTS:Twenty articles were identified, representing 15 unique cohorts. Seventeen of 18 articles showed adolescent depression increased risk for adult depression; eleven pooled cohorts estimated that adolescents with depression had 2.78 (1.97, 3.93) times increased odds of depression in adulthood. Seven of eight articles that investigated the association between adolescent depression and any adult anxiety found a significant association. Three of five articles showed a significant association between adolescent depression and adult suicidality. CONCLUSION:This review shows that adolescent depression increases the risk for subsequent depression later in life. Articles consistently found that adolescent depression increases the risk for anxiety disorders in adulthood, but evidence was mixed on whether or not a significant association existed between adolescent depression and suicidality in adulthood. Early intervention in adolescent depression may reduce long-term burden of disease.
journal_name
Depress Anxietyjournal_title
Depression and anxietyauthors
Johnson D,Dupuis G,Piche J,Clayborne Z,Colman Idoi
10.1002/da.22777subject
Has Abstractpub_date
2018-08-01 00:00:00pages
700-716issue
8eissn
1091-4269issn
1520-6394journal_volume
35pub_type
杂志文章,评审abstract:BACKGROUND:Panic disorder (PD) is highly comorbid with major depressive disorder (MDD) with potential impact on patient-reported outcomes of quality of life (QOL), functioning, and depressive symptom severity. METHODS:Using data from the sequenced treatment alternatives to relieve depression (STAR*D) trial, we compare...
journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/da.22152
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Exposure therapy, a gold-standard treatment for anxiety disorders, is assumed to work via extinction learning, but this has never been tested. Anxious individuals demonstrate extinction learning deficits, likely related to less ventromedial prefrontal cortex (vmPFC) and more amygdala activation, but the rela...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22583
更新日期:2017-03-01 00:00:00
abstract::Experimental evidence suggests that panic disorder is characterized by abnormalities in the balance system function and that these abnormalities might be related to the severity of agoraphobic avoidance. Since the balance system can be modulated by the serotonergic system, we investigated the effect of a 6-week treatm...
journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章
doi:10.1002/da.10092
更新日期:2003-01-01 00:00:00
abstract::The diagnosis of anxiety disorders and major depression can be reliably made based on signs and symptoms. However there are significant limitations to the current system of classification including overlapping criteria, high comorbidity, and the issue of subthreshold syndromes. The literature on treatment response doc...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.1049
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Patients with obsessive-compulsive disorder (OCD) experience abnormally high levels of uncertainty, and unpredictability is evaluated negatively and not well tolerated. The current study examined neural correlates of attentional processing in response to experimentally induced uncertainty in OCD. METHODS:Tw...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22655
更新日期:2017-11-01 00:00:00
abstract::Treatment-resistant depression (TRD) in adolescents is prevalent and impairing. We here review the definition, prevalence, clinical significance, risk factors, and management of TRD in adolescents. Risk factors associated with TRD include characteristics of depression (severity, level of hopelessness, and suicidal ide...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.20884
更新日期:2011-11-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20865
更新日期:2011-08-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.10124
更新日期:2003-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20903
更新日期:2011-12-21 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20510
更新日期:2010-03-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20518
更新日期:2009-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20131
更新日期:2006-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22302
更新日期:2014-11-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.1026
更新日期:2001-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
doi:10.1002/da.22253
更新日期:2014-04-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,meta分析
doi:10.1002/(sici)1520-6394(1997)6:1<10::aid-da2>3.0.c
更新日期:1997-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20703
更新日期:2010-09-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20528
更新日期:2009-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
doi:10.1002/da.22739
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Marital status is important to the epidemiology of psychiatric disorders. In particular, the high prevalence of major depression in individuals with separated, divorced, or widowed status has been well documented. However, the literature is divided as to whether marital disruption results in major depression...
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doi:10.1002/da.20618
更新日期:2009-01-01 00:00:00
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journal_title:Depression and anxiety
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更新日期:2018-11-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
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更新日期:2013-10-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1520-6394(1996)4:4<182::AID-DA4>3.0.
更新日期:1996-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
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journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Depression and anxiety
pub_type: 杂志文章
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