Abstract:
BACKGROUND/OBJECTIVE:The role of the neuropeptide oxytocin (OT) in Borderline Personality Disorder (BPD) is poorly understood. It is particularly unknown how early experiences with caregivers moderate the action of OT in BPD. Here, we examined the association of plasma OT levels in BPD patients with the experience of compassion and recalled parental behavior during childhood. METHODS:Fifty-seven BPD patients and 43 healthy controls participated in the study. OT plasma levels were analyzed by radioimmunoassay. Subjects additionally completed questionnaires focusing on fears of compassion (FOC) and recalled upbringing ("Questionnaire of Recalled Parental Rearing Behavior/Fragebogen zum erinnerten elterlichen Erziehungsverhalten," FEE). RESULTS:BPD patients had significantly lower OT plasma levels than healthy controls and differed significantly on all FOC and FEE scales; BPD patients had higher FOC scores (indicating more aversion of being compassionate to themselves and others and receiving compassion from others). They also differed in recalled parenting. In the BPD group, scores of the FOC scale "fear of compassion from others" were significantly negatively correlated with OT levels. Moreover, recalled "emotional warmth" of their parents during childhood was positively correlated with OT plasma levels of BPD subjects. No such correlations were found in the control group. CONCLUSION:Our results corroborate findings from previous studies reporting lower OT levels in patients with BPD. Moreover, peripheral OT seems to be linked with the tolerance of compassionate feelings and early experiences with caregivers. This is consistent with other findings that OT is an important mediator of the experience of emotional warmth from others.
journal_name
Depress Anxietyjournal_title
Depression and anxietyauthors
Ebert A,Edel MA,Gilbert P,Brüne Mdoi
10.1002/da.22683subject
Has Abstractpub_date
2018-01-01 00:00:00pages
50-57issue
1eissn
1091-4269issn
1520-6394journal_volume
35pub_type
杂志文章abstract:BACKGROUND:Current neurobiological models of obsessive-compulsive disorder (OCD) propose a dysfunction of cortico-striato-thalamo-cortical circuits that leads to enhanced activity in frontal and striatal brain regions. In accordance with that, OCD patients show alterations in learning and flexible adaptation to changin...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20772
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Despite the effectiveness of evidence-based treatments for posttraumatic stress disorder (PTSD), some symptoms, such as sleep disturbance, can be difficult to treat regardless of treatment type. METHODS:We examined residual PTSD symptoms in 235 female veterans and soldiers who were randomized to receive 10 ...
journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
doi:10.1002/da.22871
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Previous work has shown that inhibition of fear is impaired in posttraumatic stress disorder (PTSD) resulting from both civilian and combat trauma. The purpose of the present study was to investigate the inhibition of learned fear in traumatized individuals diagnosed with either acute stress disorder (ASD) o...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.21991
更新日期:2013-03-01 00:00:00
abstract::Anxiety disorders are among the most common psychiatric disorders, affecting one in four individuals over a lifetime. Although our understanding of the etiology of these disorders is incomplete, familial and genetic factors are established risk factors. However, identifying the specific casual genes has been difficult...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.20623
更新日期:2009-01-01 00:00:00
abstract::Although global clinical rating scales have been a mainstay of clinical research, little is known about the relationship between these measures and other assessment modalities. The present study examined the Clinician's Severity Rating (CSR) from the Anxiety Disorders Interview Schedule in a sample of 186 social phobi...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/(SICI)1520-6394(1996)4:3<120::AID-DA4>3.0.
更新日期:1996-01-01 00:00:00
abstract::It is well known that insomnia is more frequent in women than in men throughout all age groups. In this respect insomnia resembles other psychiatric disorders that occur more frequently in women such as anxiety and depressive disorders. Since insomnia is frequently a symptom of anxiety and depression, it remains an op...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.10101
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Neural activity is increasingly used in addition to behavioral measures to study anxiety and attentional biases toward threatening stimuli. Event-related potentials (ERPs) might be particularly useful because of their excellent temporal resolution. In particular, the late positive potential (LPP) reflects in...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20679
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Parental mental disorders have been shown to predict offspring's mental health problems. We examined whether pathways from parental mental disorders to offspring's psychiatric work disability in early adulthood are mediated through offspring's mental disorders and social disadvantage in adolescence. METHODS...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22847
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Depression and substance use disorders (SUDs) commonly co-occur, which presents diagnostic challenges in classifying independent major depressive disorder (MDD) versus substance-induced depressive disorder (SIDD). It remains unclear if distinct characteristics and/or patterns in temporal course distinguish M...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22122
更新日期:2013-06-01 00:00:00
abstract::The objective was to present naturalistic 1-year follow-up information of 96 child and adolescent outpatients with major depressive disorder who had been randomized in an 8-week double-blind, placebo-controlled trial of fluoxetine. Subjects were children and adolescents, ages 8-18 years, who were entered in a randomiz...
journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/(sici)1520-6394(1998)7:1<32::aid-da4>3.0.c
更新日期:1998-01-01 00:00:00
abstract::We report the case of adolescent male with obsessive-compulsive disorder (OCD) who had an incomplete response to combined cognitive-behavioral therapy (CBT) and sertraline before successful augmentation of CBT with aripiprazole. Standardized assessments indicated significant reductions in OCD symptomatology associated...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20303
更新日期:2008-01-01 00:00:00
abstract::Acute grief is emotionally intense, cognitively preoccupying, and disruptive, but grief is not an illness; major depression and anxiety disorders are. Grief and mourning have a purpose. They provide an intense, focused opportunity to reregulate emotion and to engage in a learning process that is aimed at reconfiguring...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.21963
更新日期:2012-06-01 00:00:00
abstract::Previous studies have revealed altered structural development of the frontal lobes and prefrontal cortex (PFC) in children with symptoms of posttraumatic stress disorder (PTSD). This study is the first to provide a detailed structural analysis of the PFC in children with and without PTSD symptoms. We compared gray and...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20131
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:We examined the prevalence and predictors of past-year antidepressant use in a nationally representative sample of Asian Americans and non-Latino Whites. METHODS:Analyses of 12-month antidepressant medication use were based on data from the Collaborative Psychiatric Epidemiology Surveys that surveyed Asian ...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20636
更新日期:2010-01-01 00:00:00
abstract::Clinical commentators widely interpret crying as a sign of depressed mood. However, there is virtually no empirical data on this topic, and the evidence that mood disorders alter crying is surprisingly weak. This study compared mood disordered patients to a nonpsychiatric reference group on the frequency, antecedents,...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20331
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Marital status is important to the epidemiology of psychiatric disorders. In particular, the high prevalence of major depression in individuals with separated, divorced, or widowed status has been well documented. However, the literature is divided as to whether marital disruption results in major depression...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20618
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Diagnostic criteria for DSM-5 posttraumatic stress disorder (PTSD) are in many ways similar to DSM-IV criteria, raising the possibility that it might be possible to closely approximate DSM-5 diagnoses using DSM-IV symptoms. If so, the resulting transformation rules could be used to pool research data based o...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22364
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:We used a dot-probe paradigm to examine attention bias toward threat (i.e., angry) and happy face stimuli in severe mood dysregulation (SMD) versus healthy comparison (HC) youth. The tendency to allocate attention to threat is well established in anxiety and other disorders of negative affect. SMD is charact...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22145
更新日期:2014-07-01 00:00:00
abstract::This study examined the validity of the Assessment of Depression Inventory (ADI), a 39-item measure of depression with three embedded validity scales, using inpatient participants. The ADI Depression (Dep) and Feigning (Fg) scales were compared to the corresponding scales of a widely used multiscale instrument, the Pe...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20183
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Complicated grief (CG) is a bereavement-specific syndrome distinct from but commonly comorbid with posttraumatic stress disorder (PTSD). While bereavement is common among military personnel (Simon et al., 2018), there is little research on the impact of CG comorbidity on PTSD treatment outcomes. METHODS:To ...
journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
doi:10.1002/da.22911
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Although evidence-based psychotherapies (EBPs) for posttraumatic stress disorder (PTSD) were implemented starting in 2005 in the veterans health administration (VHA), the largest national healthcare system in the U.S., the rate of initiation (uptake) and prevalence of these treatments in each calendar year h...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22983
更新日期:2020-04-01 00:00:00
abstract::Treatment-resistant depression (TRD) in adolescents is prevalent and impairing. We here review the definition, prevalence, clinical significance, risk factors, and management of TRD in adolescents. Risk factors associated with TRD include characteristics of depression (severity, level of hopelessness, and suicidal ide...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.20884
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Maintenance of gains with cognitive-behavioral treatment for trichotillomania (TTM) has historically been problematic. METHODS:We conducted follow-up assessments 3 and 6 months after completion of a 3-month maintenance phase on 10 individuals with DSM-IV-TR TTM who participated in an open trial of a dialect...
journal_title:Depression and anxiety
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/da.20778
更新日期:2011-04-01 00:00:00
abstract::Functional impairment might amplify suicide risk in later life. A positive view of the future may reduce this risk. We tested the hypothesis that hopelessness and positive future orientation moderate the association between functional status and suicide ideation in a sample of 136 patients, 55 years of age or older, i...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20224
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Adolescent suicide attempts are disproportionally prevalent and frequently of low severity, raising questions regarding their long-term prognostic implications. In this study, we examined whether adolescent attempts were associated with impairments related to suicidality, psychopathology, and psychosocial fu...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22296
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Depression and anxiety have been related to poorer self-reported physical functioning over time; however, objective measures of physical function are less frequently examined. This study assessed the 6-year trajectory of hand-grip strength and lung function in persons with depressive and/or anxiety disorders...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22557
更新日期:2017-02-01 00:00:00
abstract::Experimental evidence suggests that panic disorder is characterized by abnormalities in the balance system function and that these abnormalities might be related to the severity of agoraphobic avoidance. Since the balance system can be modulated by the serotonergic system, we investigated the effect of a 6-week treatm...
journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章
doi:10.1002/da.10092
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Although there has been abundant research on chronic low-grade inflammation as a potential mechanism underlying the link between mood disorders and cardiovascular risk, less is known about the role of inflammatory factors and anxiety disorders. The aim of this paper is to evaluate the bi-directional associat...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22710
更新日期:2018-04-01 00:00:00
abstract::Research on the effects of childhood trauma has been limited by the lack of a comprehensive, reliable, and valid instrument that assesses the occurrence of early traumatic experiences. This paper presents the development and preliminary psychometric properties of an instrument, the Early Trauma Inventory (ETI), for th...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/1520-6394(2000)12:1<1::AID-DA1>3.0.CO;2-W
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Psychosocial factors, including religious coping, consistently have been implicated in the expression of anxiety disorders. This study sought to investigate the relationship between religious coping on anxiety symptoms among a nonclinical sample of African American and European American young adults. METHOD...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20510
更新日期:2010-03-01 00:00:00