Abstract:
BACKGROUND:Parental mental disorders have been shown to predict offspring's mental health problems. We examined whether pathways from parental mental disorders to offspring's psychiatric work disability in early adulthood are mediated through offspring's mental disorders and social disadvantage in adolescence. METHODS:Study population consisted of the 1987 Finnish Birth Cohort. Data on parents' psychiatric care or work disability due to mental diagnosis between 1987 and 2000 and the cohort participants' health and social factors between 2001 and 2005 were derived from administrative national registers. From 2006 through 2015, 52,182 cohort participants were followed for admittance of psychiatric work disability due to depressive or anxiety disorders. First, we applied a pathway analysis to examine the occurrence of each path. We then used mediation analysis to assess the proportion of association between parental mental disorders and work disability mediated by offspring's health and social disadvantage. RESULTS:The pathway model indicated that the association from parental mental disorders to offspring's work disability due to depressive or anxiety disorder is through mental disorders and social disadvantage in adolescence. Odds Ratio for the total effect of parental mental disorders on offspring's psychiatric work disability was 1.85 (95% confidence interval [CI] 1.46-2.34) in the model including offspring's mental disorders that mediated this association by 35%. Corresponding results were 1.86 (95% CI 1.47-2.35) and 28% for social disadvantage in adolescence. CONCLUSIONS:These findings suggest that intergenerational determination of work disability due to mental disorders could be addressed by actions supporting mental health and social circumstances in adolescence.
journal_name
Depress Anxietyjournal_title
Depression and anxietyauthors
Halonen JI,Merikukka M,Gissler M,Kerkelä M,Virtanen M,Ristikari T,Hiilamo H,Lallukka Tdoi
10.1002/da.22847subject
Has Abstractpub_date
2019-04-01 00:00:00pages
305-312issue
4eissn
1091-4269issn
1520-6394journal_volume
36pub_type
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journal_title:Depression and anxiety
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doi:10.1002/1520-6394(2000)12:1<1::AID-DA1>3.0.CO;2-W
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pub_type: 杂志文章,随机对照试验
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22710
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doi:10.1002/da.20224
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doi:10.1002/1520-6394(2001)13:1<45::aid-da7>3.0.co;2-4
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journal_title:Depression and anxiety
pub_type: 杂志文章
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更新日期:2013-10-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
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更新日期:2012-07-01 00:00:00
abstract::Increasing attention has been paid to the role of inflammation in a host of illnesses including neuropsychiatric disorders such as depression and anxiety. Activation of the inflammatory response leads to release of inflammatory cytokines and mobilization of immune cells both of which have been shown to access the brai...
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更新日期:2013-04-01 00:00:00
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