Abstract:
:There is an urgent need for more rapidly effective pharmacotherapies for major depressive disorder and bipolar disorder (BP) that are efficacious and tolerable for depressed patients who respond poorly to conventional treatments. Multiple controlled trials have now demonstrated a rapid, nonsustained antidepressive response to a single intravenous infusion of ketamine. Early controlled studies of intranasal or serial infusion therapy appear promising. The effective dose for depression is lower than the typical anesthetic doses, and side-effects are generally mild and transient. The data investigating the adjunctive use of concurrent ketamine in the course of electroconvulsive therapy (ECT) for depression do not suggest efficacy or tolerability. The therapeutic potential of ketamine has stimulated considerable excitement among clinicians, patients, and industry, and has led to the increasing use of ketamine as an off-label substitute for ECT and other antidepressive treatments. This clinical review of ketamine will assess the evidence-based use of ketamine and initial clinical implications of further development of a potentially novel treatment for rapid reduction of symptoms in depressed patients.
journal_name
Depress Anxietyjournal_title
Depression and anxietyauthors
Bobo WV,Vande Voort JL,Croarkin PE,Leung JG,Tye SJ,Frye MAdoi
10.1002/da.22505subject
Has Abstractpub_date
2016-08-01 00:00:00pages
698-710issue
8eissn
1091-4269issn
1520-6394journal_volume
33pub_type
杂志文章,评审abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has shown safety and efficacy for treatment-resistant depression, but requires daily treatment for 4-6 weeks. Accelerated TMS, with all treatments delivered over a few days, would have significant advantages in terms of access and patient acceptance. METHO...
journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章
doi:10.1002/da.20731
更新日期:2010-10-01 00:00:00
abstract::Pediatric psychopharmacology is hindered by the relative lack of controlled, empirical clinical trials [Shatzberg and Nemeroff, 1998: Washington, D.C.: The American Psychiatric Press, Inc. p 301-306]. Psychiatric disorders in children and adolescents carry considerable morbidity, impede development, and carry a signif...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/1520-6394(2000)12:1+<85::AID-DA12>3.0.CO;2
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Internet-delivered cognitive behavioral therapy (iCBT) is a relatively novel treatment method that may improve the accessibility of mental health care for individuals with posttraumatic stress disorder (PTSD). The aim of this meta-analysis was to evaluate the effectiveness of iCBT compared to inactive (waitl...
journal_title:Depression and anxiety
pub_type: 杂志文章,meta分析,评审
doi:10.1002/da.22533
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Current neurobiological models of obsessive-compulsive disorder (OCD) propose a dysfunction of cortico-striato-thalamo-cortical circuits that leads to enhanced activity in frontal and striatal brain regions. In accordance with that, OCD patients show alterations in learning and flexible adaptation to changin...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20772
更新日期:2011-02-01 00:00:00
abstract::This review examines the question of whether there should be a cluster of disorders, including the adjustment disorders (ADs), acute stress disorder (ASD), posttraumatic stress disorder (PTSD), and the dissociative disorders (DDs), in a section devoted to abnormal responses to stress and trauma in the DSM-5. Environme...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.20845
更新日期:2011-09-01 00:00:00
abstract::This study explores the psychometric properties of the Spanish adaptation of the Mood Spectrum Self-Report (MOODS-SR), an instrument designed to assess a broad range of manifestations of mood psychopathology. A total of 71 Spanish subjects participated: 49 outpatients who met criteria for a mood disorder or generalize...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20169
更新日期:2006-01-01 00:00:00
abstract::This study replicated the factor structure of the Parental Bonding Instrument (PBI), and explored the relationships of PBI scores to demographic variables. We investigated the association between parental bonding in the parents measured by the PBI, and lifetime history of depression in their children assessed by the I...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/(sici)1520-6394(1998)8:2<65::aid-da4>3.0.c
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:The impact of the May 2008 Wenchuan earthquake, measuring a massive 8.0 on the surface wave magnitude scale, on public health in China has been significant and multifaceted. In light of extant data on prevalence and risk factors for posttraumatic stress disorder (PTSD) after other natural diasters, we collec...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20612
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Investigations of gene-environment interaction (GxE) in depression have implicated a polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) as a moderator of the stress-depression relationship. However, recent evidence for 5-HTTLPR GxE in depression has been inconsistent. This study...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20715
更新日期:2010-08-01 00:00:00
abstract::This work examines differences in the detection and distraction by social-threat-related information between a social phobia group (SP; N=33) and a normal control group (NC; N=32). The change obtained after psychological treatment is also studied for the SP group. A paper-and-pencil visual search task is used, in whic...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20269
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Adolescent depression may increase risk for poor mental health outcomes in adulthood. The objective of this study was to systematically review the literature on the association between adolescent depression and adult anxiety and depressive disorders as well as suicidality. METHODS:EMBASE, MEDLINE, and PSYCi...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.22777
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:To determine the factors, which are associated with suicidal ideation and ideas of self-harm in patients with congestive heart failure (CHF). METHODS:We examined 294 patients with documented CHF, New York Heart Association (NYHA) functional class II-IV, in a cross sectional study at three cardiac outpatient ...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20587
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Exposure therapy, a gold-standard treatment for anxiety disorders, is assumed to work via extinction learning, but this has never been tested. Anxious individuals demonstrate extinction learning deficits, likely related to less ventromedial prefrontal cortex (vmPFC) and more amygdala activation, but the rela...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22583
更新日期:2017-03-01 00:00:00
abstract::We assessed psychophysiological responses to imagery of traumatic events, panic attacks, and loss of vigilance (i.e., being hypnotized) in participants diagnosed with panic disorder. Participants were either currently experiencing nocturnal panic or daytime panics only. It was hypothesized that nocturnal panickers wou...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.10091
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Although there has been abundant research on chronic low-grade inflammation as a potential mechanism underlying the link between mood disorders and cardiovascular risk, less is known about the role of inflammatory factors and anxiety disorders. The aim of this paper is to evaluate the bi-directional associat...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22710
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:To examine (1) clinically relevant anxiety with comorbid depression in an older population, and the presentation of subthreshold symptoms; (2) to assess anxiety and levels of comorbid depression associated with migration, religion, loneliness and long-term illness. METHODS:Analysis of Wave 1 of The Irish Lon...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22893
更新日期:2019-09-01 00:00:00
abstract::The current study describes the validation of a new cognitive assessment measure for social phobia, entitled the Appraisal of Social Concerns (ASC). Item content is relevant to a range of social situations. The ASC can be used to tailor interventions to patients' idiosyncratic concerns. Data are presented from both cl...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20004
更新日期:2004-01-01 00:00:00
abstract::Numerous studies have examined the acute antidepressant effects of prefrontal transcranial magnetic stimulation (TMS). However, there is little information on whether TMS can be used as a maintenance treatment to maintain normal mood once subjects have responded. We describe seven adults with bipolar depression who re...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20027
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Treatment utilization/costs and work performance for persons with major depressive disorder (MDD) by severity of illness is not well documented. METHODS:Using National Comorbidity Survey-Replication (2001-2002) data, US workforce respondents (n=4,465) were classified by clinical severity (not clinically dep...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20580
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:There has been little research on the generalizability of clinical trials for generalized anxiety disorder (GAD). The present study examines the generalizability of pharmacological and psychotherapy clinical trials' results of individuals with DSM-IV GAD to a large community sample. METHODS:Data were drawn ...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.21937
更新日期:2012-07-01 00:00:00
abstract::There are no reports of a child taking a selective serotonin reuptake inhibitor and an atypical anti-psychotic being successfully tapered from these medications after completion of cognitive-behavioral therapy (CBT) for obsessive-compulsive disorder. With this in mind, we report the case of an 8.5-year-old male who wa...
journal_title:Depression and anxiety
pub_type: 信件
doi:10.1002/da.20448
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Psychiatrists frequently struggle with how to sequence treatment for depressed adolescents who do not respond to an adequate trial of a selective serotonin reuptake inhibitor (SSRI). This study leveraged recent statistical and computational advances to create Bayesian hierarchal models (BHMs) of response in ...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.23064
更新日期:2020-09-01 00:00:00
abstract::Current consensus on the treatment of obsessive-compulsive disorder (OCD) includes cognitive behavior therapy (CBT) in the form of exposure and response prevention (ERP). However, the generalizability of these methods to elderly populations remains largely undocumented. This clinical case study examines the effectiven...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.10024
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Maintenance of gains with cognitive-behavioral treatment for trichotillomania (TTM) has historically been problematic. METHODS:We conducted follow-up assessments 3 and 6 months after completion of a 3-month maintenance phase on 10 individuals with DSM-IV-TR TTM who participated in an open trial of a dialect...
journal_title:Depression and anxiety
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/da.20778
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Major depressive disorder (MDD) and smoking are major public health problems and epidemiologically strongly associated. However, the relationship between smoking and depression and whether this is influenced by common confounding factors remain unclear, in part due to limited longitudinal data on covariation...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22108
更新日期:2013-06-01 00:00:00
abstract::This study examined the 3-year outcome of major depression (MD)/dysthymic disorder (DD), minor depression (MinD), and subsyndromal symptomatic depression (SSD) in a population-based sample. The aims were to study the fluctuating nature of the symptoms of depression and to analyze the risk of fulfilling the criteria fo...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20231
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:There is ample evidence of the efficacy of cognitive-behavioral therapy (CBT) for depression in adolescents, including Puerto Rican adolescents. However, there is still a high percentage of adolescents who do not respond to a standard "dose" of 12 sessions of CBT. This clinical case study explores the charac...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20457
更新日期:2009-01-01 00:00:00
abstract::Since the introduction of the concept of social anxiety (or phobia) to the American nosological system in DSM-III (1980), it has become increasingly apparent that the condition is also prevalent in other cultures. In Japan, for example, the condition, called taijinkyofusho (usually abbreviated as TKS in English), is w...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/(sici)1520-6394(1997)5:3<115::aid-da1>3.0.
更新日期:1997-01-01 00:00:00
abstract::The psychometric properties of the Social Phobia Anxiety Inventory (SPAI) were assessed in a sample of participants who either had a primary diagnosis of social phobia or were normal volunteers. Positive evidence was obtained on the SPAI's concurrent and predictive convergent validity: it was significantly correlated ...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Whether psychological resilience correlates with neurocognitive performance is largely unknown. Therefore, we assessed association between neurocognitive performance and resilience in individuals with a history of childhood abuse or trauma exposure. METHODS:In this cross-sectional study of 226 highly trauma...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20675
更新日期:2010-08-01 00:00:00