Treatment of severe depression with the selective serotonin reuptake inhibitors.

Abstract:

:The selective serotonin reuptake inhibitors (SSRIs) are recognized as effective as and better tolerated than older antidepressant therapies and have become the drugs of choice in the treatment of mild to moderate depression. However, there is a clinical impression that the SSRIs are less effective than older therapies in the severely depressed patient. A limited number of trials have attempted to address this issue. This review assesses 16 controlled studies of SSRIs in severe depression. The findings from a majority of studies found the SSRIs to be superior to placebo and as effective as but better tolerated than the tricyclic antidepressants (TCAs) in severely depressed patients. Although future studies are needed to corroborate and elaborate on these data, studies still support the use of SSRIs in this patient population.

journal_name

Depress Anxiety

journal_title

Depression and anxiety

authors

Schatzberg AF

doi

10.1002/(SICI)1520-6394(1996)4:4<182::AID-DA4>3.0.

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

182-9

issue

4

eissn

1091-4269

issn

1520-6394

journal_volume

4

pub_type

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