Anxiolytic effect and memory improvement in rats by antisense oligodeoxynucleotide to 5-hydroxytryptamine-2A precursor protein.

Abstract:

:Serotonergic (5-hydroxytryptamine; 5-HT) mechanisms have been implicated in a number of physiological and pathophysiological processes including mood, anxiety, and cognitive functioning. Among the many 5-HT receptor subtypes, the 5-HT2A receptors (5-HT2A-R) seem to be of particular importance in mediating these effects, and they are prime targets for a variety of psychoactive substances-from hallucinogenic drugs, through atypical antipsychotics, to anxiolytics and antidepressants. Various selective 5-HT2A-R ligands induce different behavioral responses. To determine whether receptor downregulation is an essential part of anxiolytic action, levels of 5-HT2A receptors were manipulated in rats using a nonpharmacological approach-by the administration of an antisense oligodeoxynucleotide (ASODN) to 5-HT2A-R. Each ASODN was injected icv between two and five times at 24-hr intervals. Control rats received injections of either a scrambled oligodeoxynucleotide (ScrODN) or the vehicle only. On Day 6, anxiety-related behavior was assessed in the elevated plus maze paradigm and performance of memory tasks in the Morris water maze. Gene transcripts were measured by quantitative reverse transcription polymerase chain reaction (PCR). The results show that compared to vehicle and ScrODN control animals, icv 5-HT2A-R-ASODN administrations for 4 consecutive days (but not less) significantly decreased anxietylike behavior and improved memory retention performance. The reduction in anxiety-related behavior in 5-HT2A-R-ASODN rats was accompanied by a decrease in 5-HT2A-R-mRNA expression in the frontal cortex and in the hippocampus. Receptor downregulation has been proposed as one of the central mechanisms for anxiolytic drug actions. Antisense-mediated downmanipulation of receptors in this study, especially of 5-HT2A, supports this theory.

journal_name

Depress Anxiety

journal_title

Depression and anxiety

authors

Cohen H

doi

10.1002/da.20087

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

84-93

issue

2

eissn

1091-4269

issn

1520-6394

journal_volume

22

pub_type

杂志文章
  • How willing are you? Willingness as a predictor of change during treatment of adults with obsessive-compulsive disorder.

    abstract:OBJECTIVE:Exposure and response prevention (ERP) is an effective treatment for individuals with obsessive-compulsive disorder (OCD), yet a substantial number of individuals with OCD do not fully respond to this intervention. Based on emerging experimental and clinical research on acceptance, this study sought to explor...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22672

    authors: Reid AM,Garner LE,Van Kirk N,Gironda C,Krompinger JW,Brennan BP,Mathes BM,Monaghan SC,Tifft ED,André MC,Cattie J,Crosby JM,Elias JA

    更新日期:2017-11-01 00:00:00

  • Psychological resilience in older U.S. veterans: results from the national health and resilience in veterans study.

    abstract:BACKGROUND:Although a large body of empirical research has examined negative psychological outcomes in older veterans, relatively little is known about the prevalence and determinants of psychological resilience in this population. METHODS:A nationally representative sample of 2,025 U.S. veterans aged 60 and older (me...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22083

    authors: Pietrzak RH,Cook JM

    更新日期:2013-05-01 00:00:00

  • Measurement invariance of the patient health questionnaire-9 (PHQ-9) depression screener in U.S. adults across sex, race/ethnicity, and education level: NHANES 2005-2016.

    abstract:BACKGROUND:Despite its popularity, little is known about the measurement invariance of the Patient Health Questionnaire-9 (PHQ-9) across U.S. sociodemographic groups. Use of a screener shown not to possess measurement invariance could result in under/over-detection of depression, potentially exacerbating sociodemograph...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22940

    authors: Patel JS,Oh Y,Rand KL,Wu W,Cyders MA,Kroenke K,Stewart JC

    更新日期:2019-09-01 00:00:00

  • Posttraumatic stress disorder symptom severity is associated with reduced default mode network connectivity in individuals with elevated genetic risk for psychopathology.

    abstract:BACKGROUND:Accumulating evidence suggests that posttraumatic stress disorder (PTSD) is associated with disrupted default mode network (DMN) connectivity, but findings across studies have not been uniform. Individual differences in relevant genes may account for some of the reported variability in the relationship betwe...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22633

    authors: Miller DR,Logue MW,Wolf EJ,Maniates H,Robinson ME,Hayes JP,Stone A,Schichman S,McGlinchey RE,Milberg WP,Miller MW

    更新日期:2017-07-01 00:00:00

  • Research article: Antidepressant use among Asians in the United States.

    abstract:OBJECTIVES:We examined the prevalence and predictors of past-year antidepressant use in a nationally representative sample of Asian Americans and non-Latino Whites. METHODS:Analyses of 12-month antidepressant medication use were based on data from the Collaborative Psychiatric Epidemiology Surveys that surveyed Asian ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20636

    authors: González HM,Tarraf W,West BT,Chan D,Miranda PY,Leong FT

    更新日期:2010-01-01 00:00:00

  • Cortisol awakening response in adolescents with acute sexual abuse related posttraumatic stress disorder.

    abstract:BACKGROUND:Little is known regarding changes in the hypothalamic-pituitary-adrenal axis (HPA axis) of adolescent girls with and without posttraumatic stress disorder (PTSD) who have recently experienced sexual abuse. Therefore, in this pilot study, we utilized non-stressed home saliva collection three times a day for t...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22154

    authors: Keeshin BR,Strawn JR,Out D,Granger DA,Putnam FW

    更新日期:2014-02-01 00:00:00

  • Fluoxetine in child and adolescent depression: acute and maintenance treatment.

    abstract::The objective was to present naturalistic 1-year follow-up information of 96 child and adolescent outpatients with major depressive disorder who had been randomized in an 8-week double-blind, placebo-controlled trial of fluoxetine. Subjects were children and adolescents, ages 8-18 years, who were entered in a randomiz...

    journal_title:Depression and anxiety

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/(sici)1520-6394(1998)7:1<32::aid-da4>3.0.c

    authors: Emslie GJ,Rush AJ,Weinberg WA,Kowatch RA,Carmody T,Mayes TL

    更新日期:1998-01-01 00:00:00

  • Alternative approaches to refractory depression in bipolar illness.

    abstract::Thus, there appears to be a large variety of approaches to refractory bipolar depression. In contrast to several decades ago, wherein augmentation of lithium with antidepressants and neuroleptics was essentially the only treatment mode available, a panoply of treatment options now exist. However, their relative effica...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:

    authors: Post RM,Leverich GS,Denicoff KD,Frye MA,Kimbrell TA,Dunn R

    更新日期:1997-01-01 00:00:00

  • Generalized social phobia and avoidant personality disorder: meaningful distinction or useless duplication?

    abstract::Participants with generalized social phobia (GSP) with (n=36) and without (n=19) avoidant personality disorder (AVPD) were compared via contrasts of group means and classification analysis on purported core features of AVPD. GSP-AVPD participants proved to be more severely impaired or distressed on some group contrast...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20266

    authors: Chambless DL,Fydrich T,Rodebaugh TL

    更新日期:2008-01-01 00:00:00

  • Panic disorder: a review of DSM-IV panic disorder and proposals for DSM-V.

    abstract::This review covers the literature since the publication of DSM-IV on the diagnostic criteria for panic attacks (PAs) and panic disorder (PD). Specific recommendations are made based on the evidence available. In particular, slight changes are proposed for the wording of the diagnostic criteria for PAs to ease the diff...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/da.20654

    authors: Craske MG,Kircanski K,Epstein A,Wittchen HU,Pine DS,Lewis-Fernández R,Hinton D,DSM V Anxiety.,OC Spectrum.,Posttraumatic and Dissociative Disorder Work Group.

    更新日期:2010-02-01 00:00:00

  • Getting straight about grief.

    abstract::Acute grief is emotionally intense, cognitively preoccupying, and disruptive, but grief is not an illness; major depression and anxiety disorders are. Grief and mourning have a purpose. They provide an intense, focused opportunity to reregulate emotion and to engage in a learning process that is aimed at reconfiguring...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/da.21963

    authors: Shear MK

    更新日期:2012-06-01 00:00:00

  • Symptom profiles of DSM-IV-defined remission, recovery, relapse, and recurrence of depression: the role of the core symptoms.

    abstract:BACKGROUND:Depression outcomes in research and clinical practice are commonly defined by the concepts of remission, recovery, relapse, and recurrence. Despite their widespread use, there has been little empirical examination of these concepts. Therefore, we investigated profiles of individual symptoms during each of th...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.21960

    authors: Conradi HJ,Ormel J,de Jonge P

    更新日期:2012-07-01 00:00:00

  • TRAUMA EXPOSURE AND RISK OF SUICIDAL IDEATION AMONG ETHNICALLY DIVERSE ADULTS.

    abstract:BACKGROUND:Little is known about the association between trauma exposure and suicidal ideation across racial/ethnic groups. Our study aim was to determine the association between trauma exposure and suicidal ideation in a nationally representative ethnically diverse sample of adults. METHODS:This study included 14,866...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22485

    authors: Beristianos MH,Maguen S,Neylan TC,Byers AL

    更新日期:2016-06-01 00:00:00

  • Face-to-face versus remote administration of the Montgomery-Asberg Depression Rating Scale using videoconference and telephone.

    abstract::Although the use of telemedicine in psychiatry has a long history in providing clinical care to patients, its use in clinical trials research has not yet been commonly employed. Telemedicine allows for the remote assessment of study patients, which could be done by a centralized, highly calibrated, and impartial cohor...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20392

    authors: Kobak KA,Williams JB,Jeglic E,Salvucci D,Sharp IR

    更新日期:2008-01-01 00:00:00

  • Impact of impaired sleep on the development of PTSD symptoms in combat veterans: a prospective longitudinal cohort study.

    abstract:BACKGROUND:A significant proportion of soldiers return from deployment with symptoms of fatigue, sleep difficulties, and posttraumatic complaints. Disrupted sleep has been proposed as a contributing factor for the development of posttraumatic stress disorder (PTSD). This study investigates the impact of impaired sleep ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22054

    authors: van Liempt S,van Zuiden M,Westenberg H,Super A,Vermetten E

    更新日期:2013-05-01 00:00:00

  • Symptomatic and syndromal anxiety and depression.

    abstract::The diagnosis of anxiety disorders and major depression can be reliably made based on signs and symptoms. However there are significant limitations to the current system of classification including overlapping criteria, high comorbidity, and the issue of subthreshold syndromes. The literature on treatment response doc...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/da.1049

    authors: Ninan PT,Berger J

    更新日期:2001-01-01 00:00:00

  • Distinct associations of computer/mobile devices use and TV watching with depressive symptoms in adults: A large population study in China.

    abstract:BACKGROUND:Recent evidence shows that screen time may be an important risk factor for mental health. The aim of this study was to examine the association of computer/mobile devices (CMD) use and TV watching separately with depressive symptoms in a large representative sample of Chinese adults. METHODS:A sample of 18,9...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22932

    authors: Yu B,Gu Y,Bao X,Meng G,Wu H,Zhang Q,Liu L,Sun S,Wang X,Zhou M,Jia Q,Song K,Niu K

    更新日期:2019-09-01 00:00:00

  • Interaction of chronic stress with serotonin transporter and catechol-O-methyltransferase polymorphisms in predicting youth depression.

    abstract:BACKGROUND:Investigations of gene-environment interaction (GxE) in depression have implicated a polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) as a moderator of the stress-depression relationship. However, recent evidence for 5-HTTLPR GxE in depression has been inconsistent. This study...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20715

    authors: Conway CC,Hammen C,Brennan PA,Lind PA,Najman JM

    更新日期:2010-08-01 00:00:00

  • PTSD REMISSION AFTER PROLONGED EXPOSURE TREATMENT IS ASSOCIATED WITH ANTERIOR CINGULATE CORTEX THINNING AND VOLUME REDUCTION.

    abstract:BACKGROUND:Brain structures underlying posttraumatic stress disorder (PTSD) have been a focus of imaging studies, but associations between treatment outcome and alterations in brain structures remain largely unexamined. We longitudinally examined the relation of structural changes in the rostral anterior cingulate cort...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22471

    authors: Helpman L,Papini S,Chhetry BT,Shvil E,Rubin M,Sullivan GM,Markowitz JC,Mann JJ,Neria Y

    更新日期:2016-05-01 00:00:00

  • EEG effects of ECT: implications for rTMS.

    abstract::Electroconvulsive therapy (ECT) involves the use of electrical stimulation to elicit a series of generalized tonic-clonic seizures for therapeutic purposes and is the most effective treatment known for major depression. These treatments have significant neurophysiologic effects, many of which are manifest in the elect...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/1520-6394(2000)12:3<157::AID-DA7>3.0.CO;2-

    authors: Krystal AD,West M,Prado R,Greenside H,Zoldi S,Weiner RD

    更新日期:2000-01-01 00:00:00

  • Treatment of severe depression with the selective serotonin reuptake inhibitors.

    abstract::The selective serotonin reuptake inhibitors (SSRIs) are recognized as effective as and better tolerated than older antidepressant therapies and have become the drugs of choice in the treatment of mild to moderate depression. However, there is a clinical impression that the SSRIs are less effective than older therapies...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/(SICI)1520-6394(1996)4:4<182::AID-DA4>3.0.

    authors: Schatzberg AF

    更新日期:1996-01-01 00:00:00

  • The efficacy of metacognitive therapy for anxiety and depression: a meta-analytic review.

    abstract:BACKGROUND:Metacognitive therapy (MCT) is a relatively new approach to treating mental disorders. The aim of the current meta-analysis was to examine the efficacy of MCT in patients with mental disorders. METHOD:A comprehensive literature search revealed 16 published as well as unpublished studies on the efficacy of M...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,meta分析

    doi:10.1002/da.22273

    authors: Normann N,van Emmerik AA,Morina N

    更新日期:2014-05-01 00:00:00

  • The bidirectional relationship between anxiety disorders and circulating levels of inflammatory markers: Results from a large longitudinal population-based study.

    abstract:BACKGROUND:Although there has been abundant research on chronic low-grade inflammation as a potential mechanism underlying the link between mood disorders and cardiovascular risk, less is known about the role of inflammatory factors and anxiety disorders. The aim of this paper is to evaluate the bi-directional associat...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22710

    authors: Glaus J,von Känel R,Lasserre AM,Strippoli MF,Vandeleur CL,Castelao E,Gholam-Rezaee M,Marangoni C,Wagner EN,Marques-Vidal P,Waeber G,Vollenweider P,Preisig M,Merikangas KR

    更新日期:2018-04-01 00:00:00

  • Cognitive behavioral therapy for public-speaking anxiety using virtual reality for exposure.

    abstract::This study used an open clinical trial to test a cognitive-behavioral treatment for public-speaking anxiety that utilized virtual reality as a tool for exposure therapy. Treatment was completed by participants (n = 10) meeting the Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV criteria for social phobi...

    journal_title:Depression and anxiety

    pub_type: 临床试验,杂志文章

    doi:10.1002/da.20090

    authors: Anderson PL,Zimand E,Hodges LF,Rothbaum BO

    更新日期:2005-01-01 00:00:00

  • Parental predictors of pediatric panic disorder/agoraphobia: a controlled study in high-risk offspring.

    abstract::Our objective was to evaluate parental risk factors for pediatric-onset panic disorder/agoraphobia (PD/AG) in offspring at high risk for PD/AG. Comparisons were made between parents with PD who had a child with PD or AG (N = 27) and parents with PD without children with PD or AG (N = 79). Comparisons were also made be...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20122

    authors: Biederman J,Petty C,Faraone SV,Hirshfeld-Becker DR,Henin A,Dougherty M,Lebel TJ,Pollack M,Rosenbaum JF

    更新日期:2005-01-01 00:00:00

  • Convergent, discriminant, and criterion-related validity of the Social Phobia and Anxiety Inventory.

    abstract::The psychometric properties of the Social Phobia Anxiety Inventory (SPAI) were assessed in a sample of participants who either had a primary diagnosis of social phobia or were normal volunteers. Positive evidence was obtained on the SPAI's concurrent and predictive convergent validity: it was significantly correlated ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:

    authors: Rodebaugh TL,Chambless DL,Terrill DR,Floyd M,Uhde T

    更新日期:2000-01-01 00:00:00

  • Duration of last depressive episode may influence serum BDNF levels in remitted patients with major depression.

    abstract:BACKGROUND:Brain-derived neurotrophic factor (BDNF) may have an important role in the pathophysiology of depression. Previous studies indicate that serum BDNF levels were lower in patients with depression and increased after treatment with antidepressants. However, results of studies on serum BDNF levels in remitted pa...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.21933

    authors: Takebayashi N,Maeshima H,Baba H,Nakano Y,Satomura E,Kita Y,Namekawa Y,Nomoto H,Suzuki T,Arai H

    更新日期:2012-09-01 00:00:00

  • Impaired neural habituation to neutral faces in families genetically enriched for social anxiety disorder.

    abstract:BACKGROUND:Social anxiety disorder (SAD) is an incapacitating disorder running in families. Previous work associated social fearfulness with a failure to habituate, but the habituation response to neutral faces has, as of yet, not been investigated in patients with SAD and their family members concurrently. Here, we ex...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22962

    authors: Bas-Hoogendam JM,van Steenbergen H,Blackford JU,Tissier RLM,van der Wee NJA,Westenberg PM

    更新日期:2019-12-01 00:00:00

  • Potential mechanisms of the sleep therapies for depression.

    abstract::Sleep deprivation for one night has been investigated as a treatment for depression since the first publications describing its antidepressant properties almost 30 years ago [Pflug and Tolle, 1971: Int Pharmacopsychiatry 6:187-196]. It remains a field of active research. It is the only intervention consistently demons...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/da.1044

    authors: Ringel BL,Szuba MP

    更新日期:2001-01-01 00:00:00

  • Dysfunctional attitudes and personality disorder comorbidity during long-term treatment of MDD.

    abstract::A key component of how depression may impact personality pathology involves an understanding of how cognition and dysfunctional attitudes may change as a result of experiencing a depressive state, and how these changes may affect reporting of personality disorder symptoms. This study examines whether dysfunctional att...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/da.20174

    authors: Farabaugh A,Mischoulon D,Schwartz F,Pender M,Fava M,Alpert J

    更新日期:2007-01-01 00:00:00