Abstract:
:Electroconvulsive therapy (ECT) involves the use of electrical stimulation to elicit a series of generalized tonic-clonic seizures for therapeutic purposes and is the most effective treatment known for major depression. These treatments have significant neurophysiologic effects, many of which are manifest in the electroencephalogram (EEG). The relationship between EEG data and the response to ECT has been studied since the 1940s, but for many years no consistent correlates were found. Recent studies indicate that a number of specific EEG features recorded during the induced seizures (ictal EEG) as well as before and after a course of treatment (interictal EEG) are related to both the therapeutic efficacy and cognitive side effects. Similar to ECT, repetitive transcranial magnetic stimulation (rTMS), which involves focal electromagnetic stimulation of cortical neurons, has also been studied as an antidepressant therapy and also appears to have neurophysiologic effects, although these have not been as fully investigated as is the case with ECT. Given the similarity of these treatments, it is natural to consider whether advances in understanding the electrophysiologic correlates of the ECT response might have implications for rTMS. The present article reviews the literature on the EEG effects of ECT and discusses the implications in terms of the likely efficacy and side effects associated with rTMS in specific anatomic locations, the potential for producing an antidepressant response with rTMS without eliciting seizure activity, eliciting focal seizures with rTMS, and the possibility of using rTMS to focally modulate seizure induction and spread with ECT to optimize treatment.
journal_name
Depress Anxietyjournal_title
Depression and anxietyauthors
Krystal AD,West M,Prado R,Greenside H,Zoldi S,Weiner RDdoi
10.1002/1520-6394(2000)12:3<157::AID-DA7>3.0.CO;2-subject
Has Abstractpub_date
2000-01-01 00:00:00pages
157-65issue
3eissn
1091-4269issn
1520-6394journal_volume
12pub_type
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journal_title:Depression and anxiety
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journal_title:Depression and anxiety
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pub_type: 杂志文章,随机对照试验
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journal_title:Depression and anxiety
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journal_title:Depression and anxiety
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journal_title:Depression and anxiety
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.22777
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20268
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journal_title:Depression and anxiety
pub_type: 杂志文章,多中心研究
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journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22683
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20865
更新日期:2011-08-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20169
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.1044
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journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
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journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
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journal_title:Depression and anxiety
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