Abstract:
BACKGROUND:Brain structures underlying posttraumatic stress disorder (PTSD) have been a focus of imaging studies, but associations between treatment outcome and alterations in brain structures remain largely unexamined. We longitudinally examined the relation of structural changes in the rostral anterior cingulate cortex (rACC), a previously identified key region in the PTSD fear network, to outcome of prolonged exposure (PE) treatment. METHOD:The sample included 78 adults (53 women): 41 patients with PTSD and 37 trauma-exposed healthy volunteers (TE-HCs). Patients underwent a 10-week course of PE treatment and completed pre- and posttreatment assessments and magnetic resonance imaging (MRI) structural scans. TE-HCs also underwent assessment and MRI at baseline and 10 weeks later. PE remitters (n = 11), nonremitters (n = 14), and TE-HCs, were compared at baseline on demographic and clinical characteristics and ACC structure. Remitters, nonremitters, and TE-HCs were compared for pre- to posttreatment clinical and structural ACC change, controlling for potential confounding variables. RESULTS:There were no baseline differences in structure between PTSD and TE-HCs or remitters and nonremitters. Following treatment, PTSD remitters exhibited cortical thinning and volume decrease in the left rACC compared with PTSD nonremitters and TE-HCs. CONCLUSIONS:These results, while in need of replication, suggest that PE treatment for PTSD, by extinguishing maladaptive trauma associations, may promote synaptic plasticity and structure change in rACC. Future research should explore possible underlying mechanisms.
journal_name
Depress Anxietyjournal_title
Depression and anxietyauthors
Helpman L,Papini S,Chhetry BT,Shvil E,Rubin M,Sullivan GM,Markowitz JC,Mann JJ,Neria Ydoi
10.1002/da.22471subject
Has Abstractpub_date
2016-05-01 00:00:00pages
384-91issue
5eissn
1091-4269issn
1520-6394journal_volume
33pub_type
杂志文章abstract:BACKGROUND:Television (TV) viewing and computer use have been associated with higher risk of depression, but studies specifically assessing the impact of these and other types of sedentary behaviors (SBs) on the mental health of older adults are scarce and their results are inconclusive. Similarly, the association betw...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22804
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20268
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journal_title:Depression and anxiety
pub_type: 杂志文章,meta分析
doi:10.1002/da.22273
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20331
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journal_title:Depression and anxiety
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journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
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pub_type: 杂志文章,评审
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journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
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journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22683
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22633
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20793
更新日期:2011-05-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20580
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20304
更新日期:2008-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,meta分析
doi:10.1002/da.10096
更新日期:2003-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 信件
doi:10.1002/da.20448
更新日期:2009-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
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pub_type: 杂志文章
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/(sici)1520-6394(1998)8:1<43::aid-da9>3.0.c
更新日期:1998-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2015-06-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:
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journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
doi:10.1002/da.20174
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pub_type: 杂志文章
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