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Effect of repeated exercise stress on caspase 3, Bcl-2, HSP 70 and CuZn-SOD protein expression in mouse intestinal lymphocytes.

Abstract：

:The purpose of this study was to characterize the expression of apoptosis (caspase 3, Bcl-2) and survival (HSP 70, antioxidant CuZn-SOD) proteins in intestinal lymphocytes (IL) of mice after repeated exercise stress. Plasma corticosterone concentration was greater than twofold higher immediately after exercise compared with the non-exercised condition. IL numbers decreased 24 h after cessation of exercise (p<0.05); this was associated with increased caspase 3 (p<0.05), HSP 70 (p<0.001) and CuZn-SOD (p<0.05) expression in IL immediately after exercise relative to IL from non-exercised mice. Expression of these proteins returned to control levels 24 h after the cessation of exercise stress.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Hoffman-Goetz L,Spagnuolo PA

doi

10.1016/j.jneuroim.2007.04.012

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

94-101

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(07)00134-8

journal_volume

187

pub_type

杂志文章

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