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Thymulin induces c-fos expression in the spinal cord of rats which is reversed by meloxicam and morphine.

Abstract：

:Intraplantar (i.pl.) injections of thymulin have been shown to produce hyperalgesia in rats through a prostaglandin E2-dependent mechanism. This study aimed at investigating if such injections can produce sustained activation of spinal neurons by mapping the fos-like-immunoreactivity (FLI) as a marker for this activation. Our results showed that thymulin produces significant and sustained FLI in neurons located in spinal laminae known to be involved in nociception. Pretreatment with either morphine or meloxicam (a cyclooxygenase inhibitor) revealed differential effects on FLI and the hyperalgesia induced by thymulin. These findings support the hypothesis that thymulin can affect central neurons either directly or through the peripheral nerve terminals.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Saadé NE,Lawand HF,Safieh-Garabedian B,Kanaan SA,Atweh SF,Jabbur SJ

doi

10.1016/s0165-5728(99)00031-4

subject

Has Abstract

pub_date

1999-06-01 00:00:00

pages

16-24

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(99)00031-4

journal_volume

97

pub_type

杂志文章

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