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Characterization of natural killer cells in paired CSF and blood samples during neuroinflammation.

Abstract：

:Natural killer (NK) cells from paired CSF and blood samples of patients with multiple sclerosis (MS), other neuroinflammatory diseases (IND), and non-inflammatory neurological diseases (NIND) were characterized using flow cytometry. NK cell frequency in CSF was overall decreased compared to blood, particularly in MS patients. In contrast to blood NK cells, during neuroinflammation, CSF NK cells display an immature phenotype with bright expression of CD56 and CD27 and reduced CX3CR1 expression. Our findings suggest that, as for central memory T cells, CSF may represent an intermediary compartment for NK cell trafficking and differentiation before entering the CNS parenchyma.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Hamann I,Dörr J,Glumm R,Chanvillard C,Janssen A,Millward JM,Paul F,Ransohoff RM,Infante-Duarte C

doi

10.1016/j.jneuroim.2012.08.009

subject

Has Abstract

pub_date

2013-01-15 00:00:00

pages

165-9

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(12)00253-6

journal_volume

254

pub_type

杂志文章,多中心研究

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