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CXCR7, CXCR4 and CXCL12: an eccentric trio?

Abstract：

:CXCR7, formerly called RDC1 is a recently deorphanized G-protein coupled receptor which binds with high affinity the inflammatory and homing chemokines CXCL11/ITAC and CXCL12/SDF-1. Despite its phylogenetic relation and ligand binding properties CXCR7 does not mediate typical chemokine receptor responses such as leukocyte trafficking. Recent findings in zebrafish indicate that a critical activity of the receptor is scavenging of CXCL12 thereby generating guidance cues for CXCR4-dependent migration. The observations do not exclude the possibility that the receptor is capable of inducing signal transduction which is suggestive from studies of tumor growth and survival. The pronounced expression in central and peripheral nervous tissue and the absence of a brain phenotype in CXCR7(-/-) mice suggest a subtle activity of the receptor.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Thelen M,Thelen S

doi

10.1016/j.jneuroim.2008.04.020

subject

Has Abstract

pub_date

2008-07-31 00:00:00

pages

9-13

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(08)00104-5

journal_volume

198

pub_type

杂志文章,评审

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