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Persons with secondary progressive and relapsing remitting multiple sclerosis reveal different responses of tryptophan metabolism to acute endurance exercise and training.

Abstract：

:Disturbances in Tryptophan metabolism play a crucial role in multiple sclerosis (MS). Exercise is suspected to counteract the progress of MS and its side effects. Current research suggests alterations of Tryptophan metabolism in healthy individuals in response to exercise. We investigated the influence of acute aerobic exercise and training on Tryptophan metabolism in 57 inpatients with relapsing remitting ((RRMS) n=33) and secondary progressive ((SPMS) n=24) MS. Serotonin increased after training, whereas the kynurenine pathway was only activated in persons with RRMS. Further research is warranted to investigate whether these changes are associated with clinical measures (e.g. depressions and immune function).

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Bansi J,Koliamitra C,Bloch W,Joisten N,Schenk A,Watson M,Kool J,Langdon D,Dalgas U,Kesselring J,Zimmer P

doi

10.1016/j.jneuroim.2017.12.001

subject

Has Abstract

pub_date

2018-01-15 00:00:00

pages

101-105

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(17)30420-4

journal_volume

314

pub_type

杂志文章,随机对照试验

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