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Vascular endothelial growth factor is regulated by hypoxic stress via MAPK and HIF-1 alpha in the inner ear.

Abstract：

:Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis. The iron-chelator desferrioxamine (DFX) increased the expression of hypoxia-inducible factor (HIF)-1alpha in the hair cell line, HEI-OC1. The increased VEGF production by DFX was inhibited by iron. DFX also induced the activation of mitogen-activated protein kinase (MAPK) on HEI-OC1. The increased VEGF production by DFX was inhibited by a specific inhibitor of MAPK. In addition, DFX induced the VEGF production and HIF-1alpha stabilization in vivo. These results indicate that VEGF production is regulated via MAPK and HIF-1alpha under hypoxic condition in the inner ear.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Jeong HJ,Kim JB,Hong SH,An NH,Kim MS,Park BR,Park RK,Kim HM

doi

10.1016/j.jneuroim.2005.02.019

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

84-91

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(05)00095-0

journal_volume

163

pub_type

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