TLR-2 neutralization potentiates microglial M1 to M2 switching by the combinatorial treatment of ciprofloxacin and dexamethasone during S. aureus infection.

abstract：:An electroimmunoblotting technique was used with a monoclonal antibody to myelin basic protein (MBP) to assess demyelination in 3 defined regions of the spinal cord in rats with acute experimental autoimmune encephalomyelitis (EAE). A slight loss in MBP was detected only in the sacrococcygeal region of the spinal cord...

journal_title：Journal of neuroimmunology

authors： Kerlero de Rosbo N,Bernard CC,Simmons RD,Carnegie PR

更新日期：1985-10-01 00:00:00

abstract：:Microglia cells are the principal immune effector elements of the brain responding to any pathological event. To elucidate the possible role of microglia in initial non-inflammatory demyelination in canine distemper virus (CDV) infection, microglia from experimentally CDV infected dogs were isolated ex vivo by density...

journal_title：Journal of neuroimmunology

authors： Stein VM,Czub M,Schreiner N,Moore PF,Vandevelde M,Zurbriggen A,Tipold A

更新日期：2004-08-01 00:00:00

abstract：:A novel triptolide derivative (5R)-5-hydroxytriptolide (LLDT-8) has been shown to have potent immunosuppressive activities. Here LLDT-8 was evaluated in experimental autoimmune encephalomyelitis (EAE), the model of multiple sclerosis (MS). LLDT-8 reduced the incidence and severity of EAE, which was associated with the...

journal_title：Journal of neuroimmunology

authors： Fu YF,Zhu YN,Ni J,Zhong XG,Tang W,Zhou R,Zhou Y,Dong JR,He PL,Wan H,Li YC,Yang YF,Zuo JP

更新日期：2006-06-01 00:00:00

abstract：:The localization of dopamine stores and the expression and localization of vesicular monoamine transporter (VMAT) type-1 and 2 and of dopamine D1-like and D2-like receptor subtypes were investigated in rat thymus and spleen by immunohistochemical, immunochemical techniques and by RT-PCR. In the thymus dopamine immunor...

journal_title：Journal of neuroimmunology

authors： Mignini F,Tomassoni D,Traini E,Amenta F

更新日期：2009-01-03 00:00:00

abstract：:Clinical and experimental observations emphasize that inflammation is a direct risk factor for stroke. We performed a detailed histological and immunohistochemical analysis, assisted by digital morphometry, to compare the representative brain lesions in the ischemic core and penumbra in a rat model. Focal neuronal nec...

journal_title：Journal of neuroimmunology

authors： Horváth E,Huțanu A,Chiriac L,Dobreanu M,Orădan A,Nagy EE

更新日期：2018-11-15 00:00:00

abstract：:We investigated whether the sensory neuropeptide, calcitonin gene-related peptide (CGRP), could be synthesised by human lymphocytes. Our results indicate that in activated B-cells, there is a strong expression of CGRP gene transcripts, which is almost absent in resting cells. Since B-cells autocrinally produce NGF, th...

journal_title：Journal of neuroimmunology

authors： Bracci-Laudiero L,Aloe L,Buanne P,Finn A,Stenfors C,Vigneti E,Theodorsson E,Lundeberg T

更新日期：2002-02-01 00:00:00

abstract：:The common acute lymphoblastic leukemia antigen (CALLA), CD10, is a 100-kDa surface glycoprotein endowed with neutral endopeptidase activity, shared by a number of hemopoietic and non-hemopoietic cells. In this report, immunohistochemical and Western blot techniques, using different anti-CD10 monoclonal antibodies, we...

journal_title：Journal of neuroimmunology

authors： Cadoni A,Mancardi GL,Zaccheo D,Nocera A,Barocci S,Bianchini D,Schenone A,Capello E,Zicca A

更新日期：1993-06-01 00:00:00

abstract：:This study examined the immunoregulatory effects of anadamide, the recently identified first endogenous cannabinoid receptor ligand. Anadamide caused dose-dependent inhibition of mitogen-induced T and B lymphocyte proliferation. Its potency was 3- and 10-fold less than that of the synthetic cannabinoids delta 8-tetrah...

journal_title：Journal of neuroimmunology

authors： Schwarz H,Blanco FJ,Lotz M

更新日期：1994-11-01 00:00:00

abstract：:Thirty patients with clinically isolated syndromes (CIS) were evaluated at the onset of neurological symptoms and when they developed clinically definite MS (CDMS). Surface expression of LFA-1alpha, VLA-4 and intercellular adhesion molecule-1 (ICAM-1) on PBMC and CSF cells was evaluated using flow cytometry. Serum and...

journal_title：Journal of neuroimmunology

authors： Correale J,Bassani Molinas Mde L

更新日期：2003-07-01 00:00:00

abstract：:The skin response to myelin basic protein (MBP) was studied in chronic relapsing experimental allergic encephalomyelitis (EAE) using strain 13 guinea pigs. The delayed type skin response showed a monophasic curve; it gradually increased after immunization, reached maximum levels around 80 days post-immunization, and d...

journal_title：Journal of neuroimmunology

authors： Tabira T,Itoyama Y,Kuroiwa Y,Kubo C,Nagai Y

更新日期：1983-12-01 00:00:00

abstract：:Substance P (SP) can produce cytokine-like responses by astrocytes and mononuclear cells. In an effort to identify neurokinin-1-receptors (NK1-R), an antibody to NK1-R was generated by using a linear peptide sequence from the deduced third extracellular region (ECR) corresponding to the seven transmembrane rat brain N...

journal_title：Journal of neuroimmunology

authors： van Ginkel FW,Pascual DW

更新日期：1996-06-01 00:00:00

abstract：:Virus may be recovered from various areas of the central nervous system (CNS) of mice for as long as 11 days after inoculation of herpes simplex virus type 1 (HSV-1) into the lip. The probability of isolation from any particular region of the CNS seems to be a function of the distance of that area from the root-entry ...

journal_title：Journal of neuroimmunology

authors： Kastrukoff L,Hamada T,Schumacher U,Long C,Doherty PC,Koprowski H

更新日期：1982-06-01 00:00:00

abstract：:We reviewed the records of 391 patients who had presented with a Clinically Isolated Syndrome and selected 205 who had performed a baseline spinal tap and MRI scan. We studied cerebrospinal fluid (CSF) and serum IgM oligoclonal bands (IgMOB) using agarose gel isoelectric focusing and analyzed the impact of baseline cl...

journal_title：Journal of neuroimmunology

authors： Ferraro D,Simone AM,Bedin R,Galli V,Vitetta F,Federzoni L,D'Amico R,Merelli E,Nichelli PF,Sola P

更新日期：2013-04-15 00:00:00

abstract：:Lymphocytes isolated from Lewis rats immunised with protein antigen in adjuvant were stimulated to proliferate in vitro by splenic dendritic cells (DC) which had been pulsed with purified homologous myelin basic protein (MBP). By contrast, in parallel experiments, lymphocytes did not respond to ovalbumin unless the pr...

journal_title：Journal of neuroimmunology

authors： Gautam AM,Glynn P

更新日期：1989-04-01 00:00:00

abstract：:Our work consists of a pilot study to characterize circulating Th/c1, Th/c2, Th/c17, Treg and Tfh-like populations and IL-17 serum levels of relapsing-remitting (RR) MS patients treated with IFN-β, compared with healthy controls. In remission RRMS patients, we observe increased Th/c17 cells frequency committed to a Th...

journal_title：Journal of neuroimmunology

authors： Monteiro A,Rosado P,Rosado L,Fonseca AM,Paiva A

更新日期：2020-02-15 00:00:00

abstract：:To clarify the origin and function of the microglia residing in the central nervous system, we cloned brain cells from newborn and adult mice in soft agar containing the macrophage-specific growth factor, colony-stimulating factor-1 and expanded the cells from individual colonies in liquid culture medium. The results ...

journal_title：Journal of neuroimmunology

authors： Moore SC,McCormack JM,Armendariz E,Gatewood J,Walker WS

更新日期：1992-12-01 00:00:00

abstract：:We evaluated the brain volume and rate of atrophy in 85 Japanese patients with multiple sclerosis (MS). The mean brain volume was smaller and the rate of atrophy appeared to be more rapid in MS patients than in normal subjects. The brain atrophy seemed to exist from the early stage of MS and was prominent in the grey ...

journal_title：Journal of neuroimmunology

authors： Akaishi T,Nakashima I,Mugikura S,Aoki M,Fujihara K

更新日期：2017-05-15 00:00:00

abstract：:In this study we evaluated the percentages of CD3(-)CD56(bright), CD3(-)CD56(dim), CD3(-)CD56(bright)perforin(+) and CD3(-)CD56(dim)perforin(+) Natural Killer (NK) cells in peripheral blood from untreated secondary progressive (SP) and primary progressive (PP) multiple sclerosis (MS) patients and age and sex matched h...

journal_title：Journal of neuroimmunology

authors： Plantone D,Marti A,Frisullo G,Iorio R,Damato V,Nociti V,Patanella AK,Bianco A,Mirabella M,Batocchi AP

更新日期：2013-12-15 00:00:00

abstract：:An important extrahepatic consequence of Hepatitis C is its adverse impact on the central nervous system and cognitive performance. We aimed to determine whether there is a significant relationship between selected neurotransmitters and cytokines and cognitive performance in patients with Chronic Hepatitis C before an...

journal_title：Journal of neuroimmunology

authors： Weinstein AA,Estep JM,de Avila L,Curry M,Golabi P,Escheik C,Birerdinc A,Stepanova M,Price JK,Gerber L,Younossi ZM

更新日期：2019-10-15 00:00:00

abstract：:Stiff person spectrum disorders (SPSD) are a broad group of immune-mediated disorders. Clinical presentations include classical stiff person syndrome (SPS), focal SPS, and progressive encephalomyelitis with rigidity and myoclonus (PERM). The most frequently associated antibodies are anti-GAD65, anti-GlyR, anti-amphiph...

journal_title：Journal of neuroimmunology

authors： Bernardo F,Rebordão L,Rêgo A,Machado S,Passos J,Costa C,Cruz S,Pinto AN,Santos M

更新日期：2020-04-15 00:00:00

abstract：:The presence of immunoglobulin (Ig) free light chains (FLC) was investigated in the cerebrospinal fluid (CSF) of human immunodeficiency virus type 1 (HIV-1)-infected patients. Intrathecal synthesis of FLC was demonstrated in 80% of the patients, even in the absence of oligoclonal Ig. The FLC patterns were characterize...

journal_title：Journal of neuroimmunology

authors： Gallo P,Piccinno MG,De Rossi A,Pagni S,Amadori A,Chieco-Bianchi L,Tavolato B

更新日期：1990-03-01 00:00:00

abstract：:Targeting regulatory T cells (Treg cells) with interleukin-2 (IL-2) constitutes a novel therapeutic approach for autoimmunity. As anti-cancer therapy with IL-2 has revealed substantial toxicities a mutated human IL-2 molecule, termed AIC284 (formerly BAY 50-4798), has been developed to reduce these side effects. To as...

journal_title：Journal of neuroimmunology

authors： Weishaupt A,Paulsen D,Werner S,Wolf N,Köllner G,Rübsamen-Schaeff H,Hünig T,Kerkau T,Beyersdorf N

更新日期：2015-05-15 00:00:00

abstract：:Cells that produce tumor necrosis factor-alpha (TNF-alpha) require the presence of signaling molecules since this cytokine is not normally expressed in a constitutive manner. It has been demonstrated that glial cells can produce TNF-alpha; however, the specific inducing molecules and their mechanism(s) of action have ...

journal_title：Journal of neuroimmunology

authors： Bethea JR,Chung IY,Sparacio SM,Gillespie GY,Benveniste EN

更新日期：1992-02-01 00:00:00

abstract：:Chitin is an insoluble N-acetyl-glucosamine polymer coating fungi cell wall and several human parasites. It is hydrolysed by chitotriosidase (Chit); however, as chitin is absent in humans, the significance of human Chit activity is unknown. The level of plasma Chit activity positively correlates with Alzheimer's disea...

journal_title：Journal of neuroimmunology

authors： Sotgiu S,Musumeci S,Marconi S,Gini B,Bonetti B

更新日期：2008-06-15 00:00:00

abstract：:Little is known about antibody production within the central nervous system, called intrathecal antibody production (ITAbP). Mice infected with Theiler's murine encephalomyocarditis virus (TMEV) develop an immune-mediated demyelinating disease(TMEV-IDD), characterized by progressive weakness associated with robust ITA...

journal_title：Journal of neuroimmunology

authors： Pachner AR,Brady J,Narayan K

更新日期：2007-10-01 00:00:00

abstract：:In addition to a clear genetic disposition, environmental factors and viral infections are thought to play a role in the pathogenesis of autoimmune diseases such as type I diabetes or multiple sclerosis (MS). This article will explore, by use of paradigms developed in a transgenic mouse model, why it has been so diffi...

journal_title：Journal of neuroimmunology

authors： von Herrath MG

更新日期：2000-07-24 00:00:00

abstract：:Matrix metalloproteinase-9 (MMP-9) has been reported to be expressed in various inflammatory disorders including human T cell lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-I-infected T-cells expressed high levels of MMP-9 via viral transactivator Tax mediated act...

journal_title：Journal of neuroimmunology

authors： Kodama D,Saito M,Matsumoto W,Sabouri AH,Izumo S,Arimura K,Usuku K,Bangham CR,Osame M

更新日期：2004-11-01 00:00:00

abstract：:A single intracerebroventricular injection of 100 ng of beta-endorphin altered the course of the central nervous system (CNS) infection of a temperature-sensitive mutant of vesicular stomatitis virus (VSV), tsG31-KS5. When mice were administered beta-endorphin and then 24 h later infected intracerebrally with tsG31-KS...

journal_title：Journal of neuroimmunology

authors： Doll SC,Johnson TC

更新日期：1989-09-01 00:00:00

abstract：:Glutamate, an excitatory neurotransmitter, is neurotoxic at high concentrations. Neuroglial cells, including astrocytes and microglia, play an important role in regulating its extracellular levels. Cultured human monocytic THP-1 cells increased their glutamate secretion following 18 and 68 h exposure to the inflammato...

journal_title：Journal of neuroimmunology

authors： Klegeris A,Walker DG,McGeer PL

更新日期：1997-09-01 00:00:00

abstract：:The two chemokines, monocyte chemoattractant protein (MCP)-1 and gamma-interferon inducible protein (IP)-10, are thought to be involved in the pathogenesis of multiple sclerosis (MS). We measured MCP-1 and IP-10 levels in serum and CSF samples from 38 acute and 25 stable MS patients and from 40 controls. The latter co...

journal_title：Journal of neuroimmunology

authors： Franciotta D,Martino G,Zardini E,Furlan R,Bergamaschi R,Andreoni L,Cosi V

更新日期：2001-04-02 00:00:00