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NGF modulates CGRP synthesis in human B-lymphocytes: a possible anti-inflammatory action of NGF?

Abstract：

:We investigated whether the sensory neuropeptide, calcitonin gene-related peptide (CGRP), could be synthesised by human lymphocytes. Our results indicate that in activated B-cells, there is a strong expression of CGRP gene transcripts, which is almost absent in resting cells. Since B-cells autocrinally produce NGF, the neutralisation of endogenous NGF by anti-NGF antibodies resulted in a marked reduction in CGRP expression in both resting and activated B-cells. Thus, NGF appears to directly affect the synthesis of CGRP in B-cells as in sensory neurons. By regulating CGRP synthesis in lymphocytes and neuronal cells, NGF can influence the intensity and duration of the immune response.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Bracci-Laudiero L,Aloe L,Buanne P,Finn A,Stenfors C,Vigneti E,Theodorsson E,Lundeberg T

doi

10.1016/s0165-5728(01)00475-1

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

58-65

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165572801004751

journal_volume

123

pub_type

杂志文章

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