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Melatonin improves humoral and cell-mediated immune responses of male golden hamster following stress induced by dexamethasone.

Abstract：

:Melatonin is known as an antistress and immunostimulator compound while glucocorticoids have immunosuppressive function. The mechanism of action of both the hormones on immune cells is still a question. We found that melatonin improved the effect of dexamethasone (synthetic glucocorticoid) induced immunosuppression of splenocytes and bone marrow GM-CFU along with increased production of serum IL-2, IgG and the receptor expression for melatonin and glucocorticoid in spleen that might be responsible for the proliferation of immune cells. Thus, seasonal variation in peripheral melatonin might be responsible for the improvement of immune status under different stress conditions experienced by the rodents for better survival.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Vishwas DK,Mukherjee A,Haldar C

doi

10.1016/j.jneuroim.2013.03.002

subject

Has Abstract

pub_date

2013-06-15 00:00:00

pages

17-25

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(13)00061-1

journal_volume

259

pub_type

杂志文章

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