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Influenza virus- and cytokine-immunoreactive cells in the murine olfactory and central autonomic nervous systems before and after illness onset.

Abstract：

:Influenza virus invades the olfactory bulb (OB) and enhances cytokine mRNAs therein at the time of illness onset. Here we show that viral antigen immunoreactivity co-localized with glial markers in the OB but could not be detected in other brain areas. Interleukin 1beta- and tumor necrosis factor alpha-immunoreactivity co-localized with neuronal markers in olfactory and central autonomic systems, and the number of cytokine-immunoreactive neurons increased at the time of illness onset [15 h post-inoculation (PI)] but not before (10 h PI). These results suggest that the OB virus influences the brain cytokines and therefore the onset of illness.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Leyva-Grado VH,Churchill L,Wu M,Williams TJ,Taishi P,Majde JA,Krueger JM

doi

10.1016/j.jneuroim.2009.03.016

subject

Has Abstract

pub_date

2009-06-25 00:00:00

pages

73-83

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(09)00132-5

journal_volume

211

pub_type

杂志文章

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