Antibodies to dendritic neuronal surface antigens in opsoclonus myoclonus ataxia syndrome.

abstract：:In addition to the major histocompatibility complex (MHC), genetic susceptibility in multiple sclerosis (MS) appears to be influenced by other loci. A recent study has identified a population association with an immunoglobulin heavy chain variable region polymorphism in the VH2-B5 family, with both familial and sporad...

journal_title：Journal of neuroimmunology

authors： Hashimoto LL,Walter MA,Cox DW,Ebers GC

更新日期：1993-04-01 00:00:00

abstract：:Gangliosides modulate various T cell effector functions through poorly defined mechanisms. To begin to understand one of their effects, the present study examined how normal brain-derived gangliosides suppress T cell proliferation using the murine T cell line, EL4, as a model. Gangliosides inhibited EL4 cell growth by...

journal_title：Journal of neuroimmunology

authors： Irani DN

更新日期：1998-07-01 00:00:00

abstract：:Narcolepsy was first shown to be tightly associated with HLA-DR2 and DQ1 in 1983, suggesting a possible autoimmune mechanism. Early investigations failed to demonstrate this hypothesis, postulating that HLA-DR2 was only a linkage marker for another, unknown narcolepsy-causing gene. The autoimmune hypothesis is now bei...

journal_title：Journal of neuroimmunology

authors： Lin L,Hungs M,Mignot E

更新日期：2001-07-02 00:00:00

abstract：:Opioids have been hypothesized to suppress parameters of immune function by acting within the central nervous system to increase the activity of the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. Production of catecholamines and adrenocorticoids have been demonstrated to be responsible for man...

journal_title：Journal of neuroimmunology

authors： Hall DM,Suo JL,Weber RJ

更新日期：1998-03-15 00:00:00

abstract：:Glutamate, an excitatory neurotransmitter, is neurotoxic at high concentrations. Neuroglial cells, including astrocytes and microglia, play an important role in regulating its extracellular levels. Cultured human monocytic THP-1 cells increased their glutamate secretion following 18 and 68 h exposure to the inflammato...

journal_title：Journal of neuroimmunology

authors： Klegeris A,Walker DG,McGeer PL

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:To develop a cell-based assay (CBA) to detect aquaporin 1 (AQP1) antibodies and determine sensitivity/specificity in patients with neuromyelitis optica (NMO) spectrum disorders. METHODS:A HEK-293T transfected cell model expressing AQP1 was established and detected to be serum AQP1 antibodies. RESULTS:AQP1 a...

journal_title：Journal of neuroimmunology

authors： Long Y,Zheng Y,Shan F,Chen M,Fan Y,Zhang B,Gao C,Gao Q,Yang N

更新日期：2014-08-15 00:00:00

abstract：:Neurotuberculosis is one of the commonest HIV-associated opportunistic infections (OI) of the CNS. Cross-talk between HIV, Mycobacterium tuberculosis and host immune responses may alter expression of pattern recognition receptors (PRRs), thereby affecting cytokine profiles and functional responses. We examined PRR mRN...

journal_title：Journal of neuroimmunology

authors： Rao D,Vasanthapuram R,Satishchandra P,Desai A

更新日期：2018-05-15 00:00:00

abstract：:Research tools are urgently needed to elucidate the specificities of NMO and MS due to their clinical similarity at the early stage of the diseases. Herein, using high-field-strength MRI we characterized the optic nerve and spinal cord lesions in 2D2(tg) mice (MOG 35-55 specific TCR). Specifically, early Blood-brain B...

journal_title：Journal of neuroimmunology

authors： Bell JC,Liu Q,Gan Y,Liu Q,Liu Y,Shi FD,Turner GH

更新日期：2013-11-15 00:00:00

abstract：:Mechanism-oriented studies of EAE rely mostly on gene-modified mice on the C57BL/6 background. Here we report that MP4-induced EAE displays characteristic differences in CNS pathology as compared to MOG peptide 35-55-elicited disease. While in the latter, the topology of CNS infiltration remained unchanged throughout ...

journal_title：Journal of neuroimmunology

authors： Kuerten S,Kostova-Bales DA,Frenzel LP,Tigno JT,Tary-Lehmann M,Angelov DN,Lehmann PV

更新日期：2007-09-01 00:00:00

abstract：:Sprague-Dawley male rats implanted with chronic indwelling cannulae at the perifornical hypothalamus eat excessively during the sixth hour following administration of exogenous immune-complexing reactants to the brain site. Rabbit anti-HSA was injected, followed in 30 min by a 20-fold excess of antigen. Anaphylatoxin ...

journal_title：Journal of neuroimmunology

authors： Schupf N,Williams CA

更新日期：1987-01-01 00:00:00

abstract：:Lymphocytes isolated from Lewis rats immunised with protein antigen in adjuvant were stimulated to proliferate in vitro by splenic dendritic cells (DC) which had been pulsed with purified homologous myelin basic protein (MBP). By contrast, in parallel experiments, lymphocytes did not respond to ovalbumin unless the pr...

journal_title：Journal of neuroimmunology

authors： Gautam AM,Glynn P

更新日期：1989-04-01 00:00:00

abstract：:Polymyositis (PM) is an inflammatory muscle disease caused by autoimmune dysfunction, considered to be caused by cytotoxic CD8 T cells. To date, no autoantigens have been identified. We attempted to induce an experimental allergic myositis (EAM) in BALB/c mice by inoculating syngeneic dendritic cells (DC) presenting p...

journal_title：Journal of neuroimmunology

authors： Kawachi I,Tanaka K,Tanaka M,Tsuji S

更新日期：2001-07-02 00:00:00

abstract：:IgG fractions of sera containing anti-Hu antibodies or control sera were incubated with Hu-positive and Hu-negative cell lines. Anti-Hu IgG specifically localized in the nucleus of Hu-positive cells. Anti-Hu-positive and control sera were incubated with Hu-positive cells and human complement or peripheral blood mononu...

journal_title：Journal of neuroimmunology

authors： Hormigo A,Lieberman F

更新日期：1994-12-01 00:00:00

abstract：:Disturbances in Tryptophan metabolism play a crucial role in multiple sclerosis (MS). Exercise is suspected to counteract the progress of MS and its side effects. Current research suggests alterations of Tryptophan metabolism in healthy individuals in response to exercise. We investigated the influence of acute aerobi...

journal_title：Journal of neuroimmunology

authors： Bansi J,Koliamitra C,Bloch W,Joisten N,Schenk A,Watson M,Kool J,Langdon D,Dalgas U,Kesselring J,Zimmer P

更新日期：2018-01-15 00:00:00

abstract：:The myelin basic protein (MBP)-like material (MBPLM) in human urine is expressed in a cryptic epitope(s) present in MBP peptide 80-89 and absent or inaccessible in intact MBP. These features of urinary MBPLM have made it difficult to produce reagents for its further characterization. Using an immunogen of keyhole limp...

journal_title：Journal of neuroimmunology

authors： Whitaker JN,McKeehan A,Freeman DW

更新日期：1994-06-01 00:00:00

abstract：:We simultaneously measured 16 cytokines/chemokines in cerebrospinal fluid (CSF) from 14 patients with acute disseminated encephalomyelitis (ADEM) and 20 controls using a fluorescent bead-based immunoassay. A variety of cytokines, such as IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IFN-gamma, TNF-alpha, G-CSF and MI...

journal_title：Journal of neuroimmunology

authors： Ishizu T,Minohara M,Ichiyama T,Kira R,Tanaka M,Osoegawa M,Hara T,Furukawa S,Kira J

更新日期：2006-06-01 00:00:00

abstract：:Inbred Buffalo rats (RT-1b) have been used in studies of experimental autoimmune encephalomyelitis and autoimmune thyroiditis. Since our studies, and those of others, have relied on the genetic purity of inbred Buffalo rats, we chose to test these animals for expression of strain-dependent, allotype-specific variants ...

journal_title：Journal of neuroimmunology

authors： Jones RE,Weinberg A,Bourdette D

更新日期：1994-07-01 00:00:00

abstract：:T-cell subsets in the peripheral blood were analyzed using monoclonal antibodies during the development of experimental allergic neuritis in Lewis rats. Percentages of helper and suppressor cells and ratios of helper/suppressor cells did not exceed normal limits during the development of the disease. ...

journal_title：Journal of neuroimmunology

authors： Feasby TE,Mazaheri R,Hahn AF,Gilbert JJ,Stiller CR,Keown PA

更新日期：1984-06-01 00:00:00

abstract：:In studies of patients in Norway with multiple sclerosis (MS), we have found cross reactive autoantibodies related to the Epstein Barr virus nuclear antigen-1 (EBNA-1). The MS patients had elevated IgG antibody to EBNA-1, as measured by reactivity with a synthetic glycine/alanine peptide, P62, which represents the gly...

journal_title：Journal of neuroimmunology

authors： Vaughan JH,Riise T,Rhodes GH,Nguyen MD,Barrett-Connor E,Nyland H

更新日期：1996-09-01 00:00:00

abstract：:Current immunotherapy of myasthenia gravis (MG) is often effective, but entails risks of infection and neoplasia. The "Guided Missile" strategy described here is designed to target and eliminate the individual's unique AChR-specific T cell repertoire, without otherwise interfering with the immune system. We geneticall...

journal_title：Journal of neuroimmunology

authors： Sun W,Adams RN,Miagkov A,Lu Y,Juon HS,Drachman DB

更新日期：2012-10-15 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a disease model of multiple sclerosis (MS) that is characterized by remittance and relapse of the disease and autoimmune and demyelinating lesions in the central nervous system (CNS). To better understand the mechanism of disease relapse, we induced acute and chronic ...

journal_title：Journal of neuroimmunology

authors： Jee Y,Yoon WK,Okura Y,Tanuma N,Matsumoto Y

更新日期：2002-07-01 00:00:00

abstract：:In 1996, we reported the results of a linkage genome screen based on 129 UK multiple sclerosis multiplex families, together with follow-up typing of interesting regions in a second set of families. We have now completed screening the remainder of the genome in this second set of United Kingdom families by typing 242 m...

journal_title：Journal of neuroimmunology

authors： Hensiek AE,Roxburgh R,Smilie B,Coraddu F,Akesson E,Holmans P,Sawcer SJ,Compston DA

更新日期：2003-10-01 00:00:00

abstract：:Cytokine-polarized T cells have distinct chemokine receptor (CKR) expression patterns associated with their cytokine secretion profiles. In order to investigate this paradigm in autoreactive human T cells, we have determined the CKR expression pattern of myelin basic protein (MBP)-reactive T cell lines (TCL) and compa...

journal_title：Journal of neuroimmunology

authors： Calabresi PA,Yun SH,Allie R,Whartenby KA

更新日期：2002-06-01 00:00:00

abstract：:Neuropsychiatric manifestations of systemic lupus erythematosus (NPSLE) influence patients' quality of life and their survival. Little is known about the pathophysiological bases of NPSLE and accordingly there are no specific therapeutic agents to be employed in this setting. Genetic research in systemic lupus erythem...

journal_title：Journal of neuroimmunology

authors： Ramirez GA,Lanzani C,Bozzolo EP,Citterio L,Zagato L,Casamassima N,Canti V,Sabbadini MG,Rovere-Querini P,Manunta P,Manfredi AA

更新日期：2015-11-15 00:00:00

abstract：:Immunofluorescence studies of sural nerve demonstrated immune reactive C3d and IgM on the surface of myelin sheaths in seven patients with neuropathy and an anti-myelin-associated glycoprotein (MAG) IgM M-protein. Similar deposits of C3d and sometimes IgM were found in four of six patients with acute or chronic inflam...

journal_title：Journal of neuroimmunology

authors： Hays AP,Lee SS,Latov N

更新日期：1988-06-01 00:00:00

abstract：OBJECTIVE:It's hypothesized that gastrointestinal microbiota might play an important role in pathogenesis of multiple sclerosis (MS). The aim of the present study was to assess the prevalence of small intestinal bacterial overgrowth (SIBO) in MS patients compared with sex and age matched controls without MS. METHODS:T...

journal_title：Journal of neuroimmunology

authors： Zhang Y,Liu G,Duan Y,Han X,Dong H,Geng J

更新日期：2016-12-15 00:00:00

abstract：:In this study we aimed to investigate whether treatment with an immune modulatory drug had an effect on the distribution of B cell subpopulations in patients with remitting-relapsing multiple sclerosis (RRMS). We investigated the first-line drugs glatiramer acetate, interferon-β and natalizumab. Our data show that the...

journal_title：Journal of neuroimmunology

authors： Rovituso D,Heller S,Schroeter M,Kleinschnitz C,Kuerten S

更新日期：2014-07-15 00:00:00

abstract：:Accessory molecules and cytokines are involved in the immunopathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) in rodent models, and are potential targets for immunotherapy. Evaluation of such experimental therapies requires appropriate animal models. Therefore, we analysed the...

journal_title：Journal of neuroimmunology

authors： Laman JD,van Meurs M,Schellekens MM,de Boer M,Melchers B,Massacesi L,Lassmann H,Claassen E,Hart BA

更新日期：1998-06-01 00:00:00

abstract：:The Th1-like cytokines, interleukin 2 (IL-2), interferon gamma (IFN-gamma), and lymphotoxin alpha (LT-alpha) have been implicated in the immunopathogenesis of multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE), an animal model of immune mediated demyelination. These cytokines have been associate...

journal_title：Journal of neuroimmunology

authors： Calabresi PA,Fields NS,Farnon EC,Frank JA,Bash CN,Kawanashi T,Maloni H,Jacobson S,McFarland HF

更新日期：1998-05-15 00:00:00

abstract：:In the century and a half since multiple sclerosis (MS) was first recognized, the pathology of the condition has been defined with increasing detail. From the recognition and definition of MS as a clinical phenomenon, studies of the diseased brain tissue have progressed in a manner dependent on the science of the time...

journal_title：Journal of neuroimmunology

authors： Hickey WF

更新日期：1999-07-01 00:00:00