Abstract：
:Research tools are urgently needed to elucidate the specificities of NMO and MS due to their clinical similarity at the early stage of the diseases. Herein, using high-field-strength MRI we characterized the optic nerve and spinal cord lesions in 2D2(tg) mice (MOG 35-55 specific TCR). Specifically, early Blood-brain Barrier breakdown was observed in 86% of the 2D2(tg) mice, while the majority of mice showed little to no brain lesions. Further, immunohistology showed inflammatory infiltrates and demyelination in the brain and spinal cord that mirrored sites of MRI lesions, along with a decrease in AQP4 protein at lesion sites. Collectively, 2D2(tg) mice develop optic and spinal cord lesions that can be visualized by high-field rodent MRI and verified by pathological assessment. The similarity of these lesions with those seen in NMO patients suggests that the 2D2(tg) mouse might serve as a model for NMO research.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Bell JC,Liu Q,Gan Y,Liu Q,Liu Y,Shi FD,Turner GHdoi
10.1016/j.jneuroim.2013.09.008subject
Has Abstractpub_date
2013-11-15 00:00:00pages
35-40issue
1-2eissn
0165-5728issn
1872-8421pii
S0165-5728(13)00250-6journal_volume
264pub_type
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journal_title：Journal of neuroimmunology
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journal_title：Journal of neuroimmunology
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
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