Nerve growth factor antibody exacerbates neuropathological signs of experimental allergic encephalomyelitis in adult lewis rats.

Abstract:

:In this study, experimental allergic encephalomyelitis (EAE) rats and rats exhibiting EAE expressing high circulating anti-nerve growth factor antibody were daily monitored for clinical signs and chronic relapses. Eighty-five days after EAE induction, blood, spinal cord and brain stem were used for histological examination, nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) evaluation. The results showed that NGF-deprived rats display more severe clinical signs of disease. These effects were associated with a significant reduction of NGF in the brain stem and spinal cord but not of BDNF, which decreased only in spinal cord. These observations provide additional support to the hypothesis of a protective NGF role in rats exhibiting EAE.

journal_name

J Neuroimmunol

authors

Micera A,Properzi F,Triaca V,Aloe L

doi

10.1016/s0165-5728(99)00272-6

subject

Has Abstract

pub_date

2000-05-01 00:00:00

pages

116-23

issue

2

eissn

0165-5728

issn

1872-8421

pii

S0165572899002726

journal_volume

104

pub_type

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