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Interferon beta in multiple sclerosis: relationship between sustained serum IgG levels and clinical outcome.

Abstract：

:We investigated the effects of interferon beta-1a (IFN beta-1a) on specific response towards two immunodominant MBP peptides and on global production of IgG. We evaluated 54 sera from multiple sclerosis (MS) patients at baseline and 1 year after treatment. We did not observe any modification of immune response to the MBP peptides but we noted a significant decrease in mean IgG concentrations in patients with progression of the disease but not in stable patients. These results suggest that IFN beta1a restores or maintains a beneficial immune response.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Dubucquoi S,de Seze J,Lefranc D,Almeras L,Dutoit V,Prin L,Vermersch P

doi

10.1016/s0165-5728(02)00204-7

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

232

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165572802002047

journal_volume

129

pub_type

临床试验,杂志文章

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