Failure of intravenous immunoglobulin (IVIg) therapy in experimental autoimmune neuritis (EAN) of the Lewis rat.

abstract：:Methadone is known to exert modulatory effects on the immune system. We investigated the potential effects of methadone on infiltration of inflammatory cells into the spinal cord, as well as the proliferative and cytokine responses of T cells in MOG(35-55)-induced experimental autoimmune encephalomyelitis in mice. Met...

journal_title：Journal of neuroimmunology

authors： Kafami L,Etesami I,Felfeli M,Enayati N,Ghiaghi R,Aminian A,Dehpour A

更新日期：2013-02-15 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are believed to play a role in the pathogenesis of multiple sclerosis (MS). As methylprednisolone is the treatment of choice for a relapse, we investigated the effect of methylprednisolone on blood levels of MMPs. Baseline TIMP-1 and MMP-2 levels were lower in MS patients than in healt...

journal_title：Journal of neuroimmunology

authors： Mirowska D,Wicha W,Czlonkowski A,Czlonkowska A,Weber F

更新日期：2004-01-01 00:00:00

abstract：:Sympathetic nervous system (SNS) activation mobilizes blood leukocytes. Under these circumstances, both epinephrine (EPI) and neuropeptide Y (NPY) are released. Therefore, we investigated a possible interaction between these transmitters during leukocyte mobilization, using intravenous catheterization of male adult Le...

journal_title：Journal of neuroimmunology

authors： Bedoui S,Lechner S,Gebhardt T,Nave H,Beck-Sickinger AG,Straub RH,Pabst R,von Hörsten S

更新日期：2002-11-01 00:00:00

abstract：:HLA-DR allele subtypes in multiple sclerosis (MS) individuals in Spain were determined by restriction fragment length polymorphism (RFLP) analysis. The well-established association of DRw15, DQw6, Dw2 alleles and MS susceptibility was confirmed. The strength of its association, however, was relatively weak in our MS p...

journal_title：Journal of neuroimmunology

authors： Clerici N,Fernández M

更新日期：1992-12-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor gamma agonist pioglitazone is FDA-approved for treatment of type-2 diabetes due to insulin sensitizing effects. However pioglitazone has anti-inflammatory and neuroprotective effects, reduces glial and T-cell activation, and reduces signs in an animal model of multiple sc...

journal_title：Journal of neuroimmunology

authors： Kaiser CC,Shukla DK,Stebbins GT,Skias DD,Jeffery DR,Stefoski D,Katsamakis G,Feinstein DL

更新日期：2009-06-25 00:00:00

abstract：:Multiple sclerosis (MS) is a highly prevalent demyelinating disorder, presumed to be driven by an autoimmune response toward the central nervous system (CNS) components. All currently available treatments modulate the immune system globally and besides the reduction of disease activity, they may also impose considerab...

journal_title：Journal of neuroimmunology

authors： Wildner P,Selmaj KW

更新日期：2017-10-15 00:00:00

abstract：:Chromosome 7q21-22 and, in particular, the region surrounding D7S554 emerged from the recent American genome screen in multiple sclerosis (MS) as the most promising region genome-wide for harboring a disease susceptibility gene. We tested association between D7S554 and MS in 217 Sardinian trio MS families by the trans...

journal_title：Journal of neuroimmunology

authors： Vandenbroeck K,Fiten P,Heggarty S,Goris A,Cocco E,Hawkins SA,Graham CA,Marrosu MG,Opdenakker G

更新日期：2002-04-01 00:00:00

abstract：:Myelin proteolipid protein (PLP) is a prime candidate autoantigen for multiple sclerosis. In order to define potential immunodominant epitopes, T cell lines (TCL) from the peripheral blood of HLA-DR 15(2) MS patients were established which responded to the intact molecule of PLP. These TCL were then tested in individu...

journal_title：Journal of neuroimmunology

authors： Trotter JL,Pelfrey CM,Trotter AL,Selvidge JA,Gushleff KC,Mohanakumar T,McFarland HF

更新日期：1998-04-15 00:00:00

abstract：:The multifaceted pathogenesis of multiple sclerosis (MS) involves complex interactions between the immune and the central nervous systems which provide a multitude of targets for therapeutic interventions. Current therapies for MS are only partially effective. One potential strategy to increase treatment efficacy is t...

journal_title：Journal of neuroimmunology

authors： Milo R,Panitch H

更新日期：2011-02-01 00:00:00

abstract：:Serum anti-GM1 IgA antibodies were detected in 15 of 53 (28%) patients with the acute Guillain-Barré syndrome (GBS) and in one of 26 (4%) patients with other neurological diseases. Although nine GBS patients had anti-GM1 IgA titers of 1:200 or less, six patients had titers of 1:800 or more. Some GBS patients with anti...

journal_title：Journal of neuroimmunology

authors： Ilyas AA,Mithen FA,Chen ZW,Cook SD

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:Our aim was to investigate the correlation between onset age, clinical features and HLA-DQA1/DQB1 genetic variability in myasthenia gravis (MG) patients in Southern Han Chinese. METHODS:205 MG patients and 100 controls were genotyped for HLA-DQA1 and -DQB1 using sequence-based typing (SBT) and analyzed for h...

journal_title：Journal of neuroimmunology

authors： Zhu WH,Lu JH,Lin J,Xi JY,Lu J,Luo SS,Qiao K,Xiao BG,Lu CZ,Zhao CB

更新日期：2012-06-15 00:00:00

abstract：:Some age-related changes in immune function may be due, at least in part, to a disturbance in the communication between the nervous and immune systems. In the present work, the effects in vitro of neuropeptide Y (NPY) (10(-13) to 10(-7) M) on different peritoneal macrophage functions (adherence to substrate, chemotaxi...

journal_title：Journal of neuroimmunology

authors： De la Fuente M,Del Río M,Medina S

更新日期：2001-06-01 00:00:00

abstract：:We evaluated the association of the plasma platelet-activating factor acetylhydrolase (PAF-AH) gene polymorphism (G(994)-->T) and PAF-AH activity with susceptibility and severity of multiple sclerosis (MS) in Japanese. DNA was collected from 216 patients with clinically definite MS (65 opticospinal MS (OS-MS) and 151 ...

journal_title：Journal of neuroimmunology

authors： Osoegawa M,Niino M,Ochi H,Kikuchi S,Murai H,Fukazawa T,Minohara M,Tashiro K,Kira J

更新日期：2004-05-01 00:00:00

abstract：:Aging is associated with increased glial responsiveness that may enhance the brain's susceptibility to injury and disease. To determine whether unique age-related molecular responses occur in brain injury, we assessed mRNA levels of representative central nervous system (CNS) inflammation-related molecules in young (3...

journal_title：Journal of neuroimmunology

authors： Kyrkanides S,O'Banion MK,Whiteley PE,Daeschner JC,Olschowka JA

更新日期：2001-10-01 00:00:00

abstract：:The urokinase plasminogen activator (uPA) and its receptor (uPAR) play important physiological functions in extracellular proteolysis, as well as cell adhesion and migration. Through dysregulation of these functions, the uPA/uPAR system might be involved in the pathogenesis of AIDS dementia complex (ADC), and, in fact...

journal_title：Journal of neuroimmunology

authors： Sidenius N,Nebuloni M,Sala S,Zerbi P,Price RW,Gisslen M,Hagberg L,Vago L,Lazzarin A,Blasi F,Cinque P

更新日期：2004-12-01 00:00:00

abstract：:Lewis rats were treated from day of birth with a rabbit anti-rat IgM antiserum. As adults these animals were found to have no detectable serum IgM and greatly reduced levels of IgG. They failed to respond to the B-cell mitogen LPS, or to make antibodies to sheep red blood cells (SRBC) or myelin basic protein (BP). The...

journal_title：Journal of neuroimmunology

authors： Willenborg DO,Prowse SJ

更新日期：1983-10-01 00:00:00

abstract：:Interleukin-6 (IL-6) can activate gastrointestinal submucosal neurons, with associated implications for motility and secretory function. Patients with irritable bowel syndrome (IBS) have elevated levels of circulating IL-6. Colons from the Wistar Kyoto (WKY) rat model of IBS secrete more IL-6 (12.84 pg/ml) than contro...

journal_title：Journal of neuroimmunology

authors： O'Malley D,Dinan TG,Cryan JF

更新日期：2011-06-01 00:00:00

abstract：:The neurologic sequelae of human immunodeficiency virus (HIV) infection may be divided into primary (= HIV-induced) and secondary (= opportunistic infections and malignancies) manifestations. Our experience with 215 HIV-infected patients indicates that major clinical symptoms are due to a few, albeit important, neurol...

journal_title：Journal of neuroimmunology

authors： Fischer PA,Enzensberger W

更新日期：1988-12-01 00:00:00

abstract：:Brain capillary endothelial cells are the component of blood brain barrier, and the first line of defense against viruses invading into brain. We demonstrate that treatment of hCMEC/D3 cells, a human brain capillary endothelial cell line, with a Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly...

journal_title：Journal of neuroimmunology

authors： Imaizumi T,Sassa N,Kawaguchi S,Matsumiya T,Yoshida H,Seya K,Shiratori T,Hirono K,Tanaka H

更新日期：2018-11-15 00:00:00

abstract：:The selective kappa opioid receptor agonist MR 2034 exerted pronounced suppression of plaque-forming cell (PFC) response following intraperitoneal (i.p.) administration in the rat. Pretreatment with preferential kappa and mu opioid receptor antagonists MR 2266 and naloxone, respectively, revealed that this effect was ...

journal_title：Journal of neuroimmunology

authors： Radulović J,Miljević C,Djergović D,Vujić V,Antić J,von Hörsten S,Janković BD

更新日期：1995-03-01 00:00:00

abstract：:To demonstrate the influence of n-3 PUFA supplementation on cytokine and eicosanoid production in peripheral blood mononuclear cells (PBMCs) of MS patients (MSP), we investigated the impact of a 6-month dietary supplementation with these fatty acids on the levels of interleukin-1 beta (IL-1 beta), IL-2, interferon-gam...

journal_title：Journal of neuroimmunology

authors： Gallai V,Sarchielli P,Trequattrini A,Franceschini M,Floridi A,Firenze C,Alberti A,Di Benedetto D,Stragliotto E

更新日期：1995-02-01 00:00:00

abstract：:Activated CD4+ T lymphocytes specific for myelin basic protein (MBP) can cause experimental autoimmune encephalomyelitis (EAE) upon their inoculation into syngeneic recipients. In Lewis rats, most of the pathogenic T cell clones that develop following immunization with MBP are reactive against the 72-84 amino acid seq...

journal_title：Journal of neuroimmunology

authors： Beraud E,Balzano C,Zamora AJ,Varriale S,Bernard D,Ben-Nun A

更新日期：1993-08-01 00:00:00

abstract：:G-protein-coupled receptors (GPCR) play an important role in inflammation. Their responsiveness is regulated by G-protein-coupled receptor kinases (GRKs) and beta-arrestins. We show here that induction of experimental autoimmune encephalomyelitis (EAE) by myelin oligodendrocyte glycoprotein (MOG) resulted in a profoun...

journal_title：Journal of neuroimmunology

authors： Vroon A,Lombardi MS,Kavelaars A,Heijnen CJ

更新日期：2003-04-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) is a pro-inflammatory cytokine that emerges as a promising peripheral marker of inflammation. HMGB1 and C-reactive protein levels were assessed in plasma of control subjects and remitted patients with bipolar disorder (BD). HMGB1 levels were significantly higher in patients with BD as...

journal_title：Journal of neuroimmunology

authors： Marie-Claire C,Courtin C,Curis E,Bouaziz-Amar E,Laplanche JL,Jacob A,Etain B,Blanchard A,Bellivier F

更新日期：2019-09-15 00:00:00

abstract：:Altered peptide ligands (APL) with increased MHC-binding properties are highly effective at inducing T cell tolerance after systemic administration in soluble form, preventing experimental autoimmune encephalomyelitis (EAE) induced with the myelin basic protein (MBP) Ac1-9 peptide. We have previously described a diver...

journal_title：Journal of neuroimmunology

authors： McCue D,Ryan KR,Wraith DC,Anderton SM

更新日期：2004-11-01 00:00:00

abstract：:Previous work in our laboratory has shown that cytokine production by primary murine macrophages, and macrophage cell lines, is inhibited following treatment with the kappa-opioid agonist U50,488H. Furthermore, we have found that the participation of both accessory cells and T cells in an antibody response is suppress...

journal_title：Journal of neuroimmunology

authors： Guan L,Eisenstein TK,Adler MW,Rogers TJ

更新日期：1997-05-01 00:00:00

abstract：:This study analyzes how the antigen specificity, the subtype, and the activation state of T cells modulate their recently discovered neuroprotective potential. We assessed the prevention from neuronal damage in organotypic entorhinal-hippocampal slice cultures after co-culture with Th1 and Th2 cells either specific fo...

journal_title：Journal of neuroimmunology

authors： Wolf SA,Fisher J,Bechmann I,Steiner B,Kwidzinski E,Nitsch R

更新日期：2002-12-01 00:00:00

abstract：:Myasthenia gravis (MG) is an autoimmune disorder caused by antibody-mediated attack against skeletal muscle nicotinic acetylcholine receptor (AchR) at neuromuscular junction. A close relationship exists between heat shock proteins (HSPs) and numerous autoimmune diseases. HSPs are over expressed to protect the host aga...

journal_title：Journal of neuroimmunology

authors： Patil SA,Katyayani S,Sood A,Kavitha AK,Marimuthu P,Taly AB

更新日期：2013-04-15 00:00:00

abstract：:Astrocytic cells of unusual aspect can be detected in the cerebellum of normal mice during the first 4 weeks of life. They are visualized with anti-GFAP (glial fibrillary acidic protein), anti-S100 and anti-vimentin immune sera. Their perikaryons, located in the white matter or in the granular layer, extend long proce...

journal_title：Journal of neuroimmunology

authors： Benjelloun-Touimi S,Jacque CM,Derer P,De Vitry F,Maunoury R,Dupouey P

更新日期：1985-07-01 00:00:00

abstract：:We showed previously that mice deficient in astrocyte gap junctions Cx43 and Cx30 exhibit white matter vacuolation and hypomyelination. In this study we tested the hypothesis that loss of astrocytic gap junction proteins leads to exacerbation of the primary demyelinating diseases, using experimental autoimmune encepha...

journal_title：Journal of neuroimmunology

authors： Lutz SE,Raine CS,Brosnan CF

更新日期：2012-04-01 00:00:00