当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > T cell recognition of myelin proteolipid protein and myelin proteolipid protein peptides in the peripheral blood of multiple sclerosis and control subjects.

T cell recognition of myelin proteolipid protein and myelin proteolipid protein peptides in the peripheral blood of multiple sclerosis and control subjects.

Abstract：

:Myelin proteolipid protein (PLP) is a prime candidate autoantigen for multiple sclerosis. In order to define potential immunodominant epitopes, T cell lines (TCL) from the peripheral blood of HLA-DR 15(2) MS patients were established which responded to the intact molecule of PLP. These TCL were then tested in individual proliferation assays with a variety of PLP peptides spanning most of the PLP molecule. Multiple peptides were recognized by TCL from the MS population, with more than one peptide often recognized by lines from the same individual. Three immunodominant peptides were identified which were recognized by the majority of MS patients. Estimated frequency analyses were then performed on the peripheral blood of HLA-DR15(2)-positive MS and control subjects using TCL initiated by the three immunodominant peptides, 40-60, 95-117, and 185-206. TCL from HLA-DR15 MS subjects recognized peptide 95-117 significantly more often than TCL from control subjects.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Trotter JL,Pelfrey CM,Trotter AL,Selvidge JA,Gushleff KC,Mohanakumar T,McFarland HF

doi

10.1016/s0165-5728(97)00260-9

subject

Has Abstract

pub_date

1998-04-15 00:00:00

pages

172-8

issue

2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(97)00260-9

journal_volume

84

pub_type

杂志文章

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