当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > T-cell repertoire profiling by next-generation sequencing reveals tissue migration dynamics of TRBV13-family clonotypes in a common experimental autoimmune encephalomyelitis mouse model.

T-cell repertoire profiling by next-generation sequencing reveals tissue migration dynamics of TRBV13-family clonotypes in a common experimental autoimmune encephalomyelitis mouse model.

Abstract：

:The experimental autoimmune encephalomyelitis (EAE) model is indispensable for autoimmunity research, but model-specific T cell dynamics are sparsely studied. We used next-generation immunosequencing across lymphoid organs, blood and spinal cord in response to immunization with myelin basic protein (MBP) to study T cell repertoires and migration patterns. Surprisingly, most spinal cord T cells were unique to the individual animal despite the existence of shared MBP-specific clones, suggesting a previously underestimated T cell diversity. Almost complete emigration of pathogenic clones from blood to spinal cord indicates that blood is not a suitable compartment to study EAE-mediating T cells.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Schliffke S,Carambia A,Akyüz N,Thiele B,Herkel J,Binder M

doi

10.1016/j.jneuroim.2019.03.014

subject

Has Abstract

pub_date

2019-07-15 00:00:00

pages

49-56

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(18)30573-3

journal_volume

332

pub_type

杂志文章

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