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The neuropeptides α-MSH and NPY modulate phagocytosis and phagolysosome activation in RAW 264.7 cells.

Abstract：

:Within the immunosuppressive ocular microenvironment, there are constitutively present the immunomodulating neuropeptides alpha-melanocyte stimulating hormone (α-MSH) and neuropeptide Y (NPY) that promote suppressor functionality in macrophages. In this study, we examined the possibility that α-MSH and NPY modulate phagocytic activity in macrophages. The macrophages treated with α-MSH and NPY were significantly suppressed in their capacity to phagocytize unopsonized Escherichia coli and Staphylococcus aureus bioparticles, but not antibody-opsonized bioparticles. The neuropeptides significantly suppressed phagolysosome activation, and the FcR-associated generation of reactive oxidative species as well. This suppression corresponds to neuropeptide modulation of macrophage functionality within the ocular microenvironment to suppress the activation of immunogenic inflammation.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Phan TA,Taylor AW

doi

10.1016/j.jneuroim.2013.04.019

subject

Has Abstract

pub_date

2013-07-15 00:00:00

pages

9-16

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(13)00116-1

journal_volume

260

pub_type

杂志文章

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