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Persistent immune activation associated with a mouse model of Staphylococcus aureus-induced experimental brain abscess.

Abstract：

:We have established a mouse experimental brain abscess model using Staphylococcus aureus where lesion sites are greatly exaggerated compared to the localized area of initial infection, reminiscent of an overactive immune response. Here we demonstrate the prolonged expression of IL-1 beta, TNF-alpha, and macrophage inflammatory protein-2 (MIP-2/CXCL2), concomitant with a chronic disruption of the blood-brain barrier (BBB) in mice with S. aureus-induced brain abscess. These changes correlated with the continued presence of infiltrating neutrophils and macrophages/microglia. Collectively these findings suggest that the excessive tissue damage that often results from brain abscess may be mediated, in part, by the perpetuation of antibacterial immune responses that are not downregulated in a timely manner.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Baldwin AC,Kielian T

doi

10.1016/j.jneuroim.2004.02.002

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

24-32

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165572804000682

journal_volume

151

pub_type

杂志文章

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