当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > The role of macrophages in demyelination.

The role of macrophages in demyelination.

Abstract：

:Experimental allergic encephalomyelitis (EAE) is an autoimmune inflammatory disease of the central nervous system (CNS). In particular in the CsA-induced chronic relapsing form (CREAE), pronounced demyelination occurs, in temporal association with relapses. It is still a matter of discussion which cell type ultimately is responsible for the actual process of demyelination. Macrophages, cytotoxic T lymphocytes and also astrocytes are possible candidates. In this short overview, the role of macrophages in the pathogenesis of EAE is discussed. It is shown that in particular, newly recruited macrophages play a crucial role in the generation of clinical signs. Possible mechanisms by which macrophages are involved in the pathogenesis of demyelinating diseases are presented.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Dijkstra CD,De Groot CJ,Huitinga I

doi

10.1016/0165-5728(92)90132-5

subject

Has Abstract

pub_date

1992-10-01 00:00:00

pages

183-8

issue

2-3

eissn

0165-5728

issn

1872-8421

pii

0165-5728(92)90132-5

journal_volume

40

pub_type

杂志文章,评审

相关文献

JOURNAL OF NEUROIMMUNOLOGY文献大全
  • Caveolin-3 is aberrantly expressed in skeletal muscle cells in myasthenia gravis.

    abstract：:Caveolin-3 is a muscle-specific membrane protein that localizes to the sarcolemma and T-tubule system. Caveolin-3 is needed for muscle repair and skeletal muscle development. The objective of this study was to compare caveolin-3 expression in myasthenia gravis (MG) and control muscles. Caveolin-3 was abnormally expres...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2016.10.011

    authors： Iwasa K,Furukawa Y,Yoshikawa H,Yamada M

    更新日期：2016-12-15 00:00:00

  • Crosstalk between cancer and the neuro-immune system.

    abstract：:In the last decade, understanding of cancer initiation and progression has been given much attention with studies mainly focusing on genetic abnormalities. Importantly, cancer cells can influence their microenvironment and bi-directionally communicate with other systems such as the immune system. The nervous system pl...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jneuroim.2017.12.016

    authors： Kuol N,Stojanovska L,Apostolopoulos V,Nurgali K

    更新日期：2018-02-15 00:00:00

  • Glial activation and midkine and pleiotrophin transcription in the ventral tegmental area are modulated by morphine administration.

    abstract：:Opiates cause persistent restructuring in the mesolimbic reward system. Although a possible role for midkine and pleiotrophin cytokines in the field of synaptic plasticity has been proposed, it has not been assessed whether morphine administration regulates astrogliosis and midkine and pleiotrophin transcription. We o...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2014.07.017

    authors： García-Pérez D,Luisa Laorden M,Núñez C,Victoria Milanés M

    更新日期：2014-09-15 00:00:00

  • Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes: implications for multiple sclerosis.

    abstract：:Peroxisome proliferator-activated receptor (PPAR)-gamma agonists, including thiazolidinediones (TZDs) and 15-deoxy-Delta(12,14) prostaglandin J(2) (15d-PGJ(2)), have been shown to be effective in the treatment of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). This study ai...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2004.12.015

    authors： Storer PD,Xu J,Chavis J,Drew PD

    更新日期：2005-04-01 00:00:00

  • Inhaled budesonide protects against chronic asthma-induced neuroinflammation in mouse brain.

    abstract：:Chronic asthma is one of the most common respiratory diseases, characterized by airway inflammation. However, little is known whether asthma-induced airway inflammation might influence the brain. We found that chronic asthma not only resulted in peripheral inflammation, but also induced neuroinflammation which was cha...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2014.06.005

    authors： Xia MX,Ding X,Qi J,Gu J,Hu G,Sun XL

    更新日期：2014-08-15 00:00:00

  • Occurrence and clinical relevance of an interleukin-4 gene polymorphism in patients with multiple sclerosis.

    abstract：:An epistatic gene interaction has been advocated to explain disease susceptibility in multiple sclerosis (MS). Cytokine genes are possible candidates due to the central role played by cytokines in the regulation of the immune-mediated pathogenetic process leading to central nervous system demyelination in these patien...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(97)00058-1

    authors： Vandenbroeck K,Martino G,Marrosu M,Consiglio A,Zaffaroni M,Vaccargiu S,Franciotta D,Ruggeri M,Comi G,Grimaldi LM

    更新日期：1997-06-01 00:00:00

  • The role of exosomes in CNS inflammation and their involvement in multiple sclerosis.

    abstract：:Multiple sclerosis (MS) is a putative autoimmune disease of the central nervous system (CNS) in which autoreactive immune cells recognizing myelin antigens lead to demyelination and axonal injury. Mechanisms relevant to the pathogenesis of MS have not been fully elucidated, particularly those underlying initiation of ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jneuroim.2017.02.002

    authors： Selmaj I,Mycko MP,Raine CS,Selmaj KW

    更新日期：2017-05-15 00:00:00

  • Corticotropin-releasing hormone is involved in conditioned stimulus-induced reduction of natural killer cell activity but not in conditioned alterations in cytokine production or proliferation responses.

    abstract：:Research from our laboratory has demonstrated that the presentation of an aversive conditioned stimulus produces pronounced suppression of several in vitro measures of immune status. The present study was designed to evaluate the role of central corticotropin-releasing hormone (CRH) in the mechanisms mediating these c...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(95)00119-0

    authors： Perez L,Lysle DT

    更新日期：1995-12-01 00:00:00

  • Antidepressant drug administration modifies the interactive relationship between alpha(2)-adrenergic sensitivity and levels of TNF in the rat brain.

    abstract：:A reciprocally permissive interaction occurs between cellular responses elicited by the pleiotropic cytokine tumor necrosis factor-alpha (TNF) and alpha(2)-adrenergic receptor activation, such that each may adapt in response to modifications in the other's effects. Changes in presynaptic adrenergic sensitivity as well...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(00)00244-7

    authors： Nickola TJ,Ignatowski TA,Spengler RN

    更新日期：2000-07-10 00:00:00

  • Pharmacological modulation of neuropeptides in peripheral mononuclear cells.

    abstract：:The concentrations of beta-endorphin and cholecystokinin were measured in fresh resting peripheral mononuclear cells obtained from rats and human subjects in basal conditions and after different pharmacological treatments. Both in the human and the rat, beta-endorphin concentrations in mononuclear cells, increased aft...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(91)90069-j

    authors： Sacerdote P,Rubboli F,Locatelli L,Ciciliato I,Mantegazza P,Panerai AE

    更新日期：1991-04-01 00:00:00

  • Differential induction of interleukin-I beta mRNA in the brain parenchyma of Lewis and Fischer rats after peripheral injection of lipopolysaccharides.

    abstract：:The expression of interleukin-1 beta (IL-1beta) mRNA was compared in the brain of inflammatory susceptible LEW/N and resistant F344/N rats at 3, 6, and 12 h after peripheral administration of lipopolysaccharide (LPS) or saline. No differences between strains were observed in the circumventricular organs (CVOs) and cho...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(03)00171-1

    authors： Tonelli LH,Maeda S,Rapp KL,Sternberg EM

    更新日期：2003-07-01 00:00:00

  • Transforming growth factor-beta 1 inhibits tumor necrosis factor-alpha/lymphotoxin production and adoptive transfer of disease by effector cells of autoimmune encephalomyelitis.

    abstract：:We previously reported that the CD4+ suppressor cells (Ts) that regulate recovery of Lewis rats from experimental autoimmune encephalomyelitis (EAE) produce transforming growth factor-beta (TGF-beta). We also reported that TGF-beta downregulates interferon-gamma (IFN-gamma), but not interleukin-2 (IL-2) production, by...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(94)90131-7

    authors： Stevens DB,Gould KE,Swanborg RH

    更新日期：1994-04-01 00:00:00

  • Platelet-activating factor receptor gene polymorphism in Japanese patients with multiple sclerosis.

    abstract：:We evaluated the association of the platelet-activating factor receptor (PAFR) gene polymorphism (A224D) with the susceptibility and severity of multiple sclerosis (MS) in a Japanese population. DNA was collected from 162 Japanese patients with clinically definite 'conventional' MS (MS) and 245 healthy controls. The m...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2004.12.014

    authors： Osoegawa M,Miyagishi R,Ochi H,Nakamura I,Niino M,Kikuchi S,Murai H,Fukazawa T,Minohara M,Tashiro K,Kira J

    更新日期：2005-04-01 00:00:00

  • Exosomes from adipose-derived stem cells alleviate neural injury caused by microglia activation via suppressing NF-kB and MAPK pathway.

    abstract：:Activation of microglia cells play critical role in neuroinflammation after brain injury. Exosomes from adipose-derived stem cells (ADSC) possess immunoregulation effect similar with ADSC. We hypothesized that ADSC derived exosomes (ADSC-exosomes) could inhibit the activation of microglia cells and prevent neuroinflam...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2019.576996

    authors： Feng N,Jia Y,Huang X

    更新日期：2019-09-15 00:00:00

  • Contribution of the macrophage migration inhibitory factor superfamily of cytokines in the pathogenesis of preclinical and human multiple sclerosis: In silico and in vivo evidences.

    abstract：:Macrophage migration inhibitory factor (MIF) is a cytokine with pleiotropic actions involved in the pathogenesis of autoimmune disorders, including Multiple Sclerosis (MS). We have first evaluated in silico the involvement of MIF, its homologue D-DT, and the receptors CD74, CD44, CXCR2 and CXCR4 in encephalitogenic T ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2018.06.009

    authors： Fagone P,Mazzon E,Cavalli E,Bramanti A,Petralia MC,Mangano K,Al-Abed Y,Bramati P,Nicoletti F

    更新日期：2018-09-15 00:00:00

  • TNF and sTNFR1/2 plasma levels in ALS patients.

    abstract：:The involvement of the immune system has been hypothesized in the pathogenesis of amyotrophic lateral sclerosis (ALS). In this study a significantly higher level of TNF-alpha and its soluble receptors, TNF-R1 and TNF-R2, has been found in plasma of patients affected by the sporadic form of ALS compared to normal subje...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2007.10.028

    authors： Cereda C,Baiocchi C,Bongioanni P,Cova E,Guareschi S,Metelli MR,Rossi B,Sbalsi I,Cuccia MC,Ceroni M

    更新日期：2008-02-01 00:00:00

  • B1 cells are unaffected by immune modulatory treatment in remitting-relapsing multiple sclerosis patients.

    abstract：:In this study we aimed to investigate whether treatment with an immune modulatory drug had an effect on the distribution of B cell subpopulations in patients with remitting-relapsing multiple sclerosis (RRMS). We investigated the first-line drugs glatiramer acetate, interferon-β and natalizumab. Our data show that the...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2014.04.008

    authors： Rovituso D,Heller S,Schroeter M,Kleinschnitz C,Kuerten S

    更新日期：2014-07-15 00:00:00

  • Serotonergic aspects of the response of human platelets to immune-adjuvant muramyl dipeptide.

    abstract：:The human platelet serotonergic responses of aggregation and uptake were shown to be modulated by muramyl peptides. Muramyl dipeptide inhibited serotonin uptake in a temperature dependent and stereospecific manner. It also blocked the binding to platelets of [3H]imipramine, a well-known inhibitor of serotonin uptake. ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(92)90166-i

    authors： Polanski M,Karnovsky ML

    更新日期：1992-03-01 00:00:00

  • Evidence that mouse astrocytes may be derived from the radial glia. An immunohistochemical study of the cerebellum in the normal and reeler mouse.

    abstract：:Astrocytic cells of unusual aspect can be detected in the cerebellum of normal mice during the first 4 weeks of life. They are visualized with anti-GFAP (glial fibrillary acidic protein), anti-S100 and anti-vimentin immune sera. Their perikaryons, located in the white matter or in the granular layer, extend long proce...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(85)80009-6

    authors： Benjelloun-Touimi S,Jacque CM,Derer P,De Vitry F,Maunoury R,Dupouey P

    更新日期：1985-07-01 00:00:00

  • Brain ingress of regulatory T cells in a murine model of HIV-1 encephalitis.

    abstract：:CD4+CD25+ regulatory T cells (Treg) transform the HIV-1 infected macrophage from a neurotoxic to a neuroprotective phenotype. This was demonstrated previously in a murine model of HIV-1 encephalitis induced by intracranial injection of HIV-1/vesicular stomatitis virus-infected bone marrow macrophages. In this report, ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2010.08.014

    authors： Gong N,Liu J,Reynolds AD,Gorantla S,Mosley RL,Gendelman HE

    更新日期：2011-01-01 00:00:00

  • Tumor necrosis factor alpha (TNF-α), anti-TNF-α and demyelination revisited: an ongoing story.

    abstract：:Tumor necrosis factor alpha (TNF-α) is a cytokine with pleiotropic actions that can be present both as a transmembrane protein and soluble cytokine (sTNF). Both ligands interact with two different receptors, TNFR1 and TNFR2, which mediate their biological effects. TNF-α is involved in the pathogenesis of multiple scle...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jneuroim.2011.03.004

    authors： Caminero A,Comabella M,Montalban X

    更新日期：2011-05-01 00:00:00

  • Loss of astrocyte connexins 43 and 30 does not significantly alter susceptibility or severity of acute experimental autoimmune encephalomyelitis in mice.

    abstract：:We showed previously that mice deficient in astrocyte gap junctions Cx43 and Cx30 exhibit white matter vacuolation and hypomyelination. In this study we tested the hypothesis that loss of astrocytic gap junction proteins leads to exacerbation of the primary demyelinating diseases, using experimental autoimmune encepha...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2012.01.007

    authors： Lutz SE,Raine CS,Brosnan CF

    更新日期：2012-04-01 00:00:00

  • Immunological patterns identifying disease course and evolution in multiple sclerosis patients.

    abstract：:Reliable, and easy to measure, immunological markers able to denote disease characteristics in multiple sclerosis (MS) patients are still lacking. We applied a multivariate statistical analysis on results obtained by measuring-by real-time RT-PCR-mRNA levels of 25 immunological relevant molecules in PBMCs from 198 MS ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2005.04.012

    authors： Furlan R,Rovaris M,Martinelli Boneschi F,Khademi M,Bergami A,Gironi M,Deleidi M,Agosta F,Franciotta D,Scarpini E,Uccelli A,Zaffaroni M,Kurne A,Comi G,Olsson T,Filippi M,Martino G

    更新日期：2005-08-01 00:00:00

  • Neuromyelitis optica and anti-aquaporin-4 antibodies measured by an enzyme-linked immunosorbent assay.

    abstract：:NMO-IgG, a disease-specific autoantibody for neuromyelitis optica, recognizes aquaporin-4 (AQP4) and has been examined by indirect immunofluorescence assay. We developed an enzyme-linked immunosorbent assay (ELISA) to detect anti-AQP4 antibodies by establishing methods for expression in a baculovirus system and purifi...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2008.03.009

    authors： Hayakawa S,Mori M,Okuta A,Kamegawa A,Fujiyoshi Y,Yoshiyama Y,Mitsuoka K,Ishibashi K,Sasaki S,Hattori T,Kuwabara S

    更新日期：2008-05-30 00:00:00

  • Arecoline a muscarinic cholinergic agent conditions central pathways that modulate natural killer cell activity.

    abstract：:The central nervous system plays an active role in the regulation of the immune system. Modulation of immune activities appears to be in part under the control of the hypothalamic-pituitary-adrenal (HPA) axis. We investigated the effect of a muscarinic cholinergic agonist, arecoline, which stimulates the secretion of ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(95)00025-w

    authors： Demissie S,Rogers CF,Hiramoto NS,Ghanta VK,Hiramoto RN

    更新日期：1995-06-01 00:00:00

  • HTLV-I specific IFN-gamma+ CD8+ lymphocytes correlate with the proviral load in peripheral blood of infected individuals.

    abstract：:Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an inflammatory neurological disease caused by HTLV-I infection. It has been shown that HAM/TSP patients have high proviral loads and an extraordinarily high frequency of circulating CD8 + cytotoxic T lymphocytes...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(99)00175-7

    authors： Kubota R,Kawanishi T,Matsubara H,Manns A,Jacobson S

    更新日期：2000-01-24 00:00:00

  • Glatiramer acetate-reactive T lymphocytes regulate oligodendrocyte progenitor cell number in vitro: role of IGF-2.

    abstract：:Glatiramer acetate (GA) is an immunomodulator approved for therapy of relapsing-remitting multiple sclerosis (RRMS), but recent findings indicate that it may also have additional, neurotrophic effects. Here, we found that supernatants from human GA-reactive T lymphocytes potentiated oligodendrocyte numbers in rodent a...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2010.06.014

    authors： Zhang Y,Jalili F,Ouamara N,Zameer A,Cosentino G,Mayne M,Hayardeny L,Antel JP,Bar-Or A,John GR

    更新日期：2010-10-08 00:00:00

  • "Allograft-inflammatory-factor-1 is upregulated in microglial cells in human cerebral infarctions".

    abstract：:Allograft inflammatory factor-1 (AIF-1) is a 17-kDa-peptide identified in rat cardiac allografts undergoing chronic rejection and in activated microglial cells in inflammatory autoimune disease of the CNS. We have investigated the expression of AIF-1 in 18 autopsy cases of human focal cerebral infarction. AIF-1-positi...

    journal_title：Journal of neuroimmunology

    pub_type： 更正并重新发布的文章,杂志文章

    doi：10.1016/s0165-5728(00)00283-6

    authors： Postler E,Rimner A,Beschorner R,Schluesener HJ,Meyermann R

    更新日期：2000-08-01 00:00:00

  • Nerve growth factor antibody exacerbates neuropathological signs of experimental allergic encephalomyelitis in adult lewis rats.

    abstract：:In this study, experimental allergic encephalomyelitis (EAE) rats and rats exhibiting EAE expressing high circulating anti-nerve growth factor antibody were daily monitored for clinical signs and chronic relapses. Eighty-five days after EAE induction, blood, spinal cord and brain stem were used for histological examin...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(99)00272-6

    authors： Micera A,Properzi F,Triaca V,Aloe L

    更新日期：2000-05-01 00:00:00

  • Impaired immune responsiveness is an essential component in persistent central nervous system infection with gross murine leukemia virus.

    abstract：:Exposure of newborn mice to Gross murine leukemia virus (GMuLV) results in persistent viral infection of the central nervous system (CNS) white matter. Animals exposed to virus as neonates showed a marked depression in GMuLV-specific B lymphocyte function as evidenced by significant decreases in adult and neonatal ant...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(91)90093-m

    authors： Korostoff JM,Nakada MT,Markman JF,Gaulton GN

    更新日期：1991-10-01 00:00:00