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Glial activation and midkine and pleiotrophin transcription in the ventral tegmental area are modulated by morphine administration.

Abstract：

:Opiates cause persistent restructuring in the mesolimbic reward system. Although a possible role for midkine and pleiotrophin cytokines in the field of synaptic plasticity has been proposed, it has not been assessed whether morphine administration regulates astrogliosis and midkine and pleiotrophin transcription. We observed that single morphine injection and chronic morphine increased glial fibrillary acidic protein expression in the ventral tegmental area (VTA). Interestingly, single morphine injection and chronic morphine increased VTA midkine and pleiotrophin mRNA expression. Given these results, we hypothesize a role for these cytokines in mediating, at least in part, acute neuroprotective effects and chronic neurotrophic adaptations that contribute to drug dependence.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

García-Pérez D,Luisa Laorden M,Núñez C,Victoria Milanés M

doi

10.1016/j.jneuroim.2014.07.017

subject

Has Abstract

pub_date

2014-09-15 00:00:00

pages

244-8

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(14)00232-X

journal_volume

274

pub_type

杂志文章

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