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Toll-like receptor-2 deficiency is associated with enhanced brain TNF gene expression during pneumococcal meningitis.

Abstract：

:TNF is a marker of disease activity in bacterial meningitis. To investigate TNF modulation by Toll-like receptor-2 (TLR2), we studied temporal and anatomical expression patterns of TLR2 and TNF in a pneumococcal meningitis model in wild type (wt) and TLR2(-/-) mice. We show by in situ hybridization that transcripts of TLR2 and of the comolecules CD14, MD-2, TLR1/6 strongly increased and colocalized with TNF in CD45-positive infiltrating cells in the ventricles, corpus callosum and the meninges. TNF gene and protein expression was stronger in TLR2(-/-) than wt brains and associated with increased IkappaB expression suggesting that TLR2 is controlling inflammation via TNF regulation.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Letiembre M,Echchannaoui H,Ferracin F,Rivest S,Landmann R

doi

10.1016/j.jneuroim.2005.06.016

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

21-33

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(05)00225-0

journal_volume

168

pub_type

杂志文章

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