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Expression of an alpha7 duplicate nicotinic acetylcholine receptor-related protein in human leukocytes.

Abstract：

:We examined the potential expression and function of alpha7 nicotinic acetylcholine receptors (nAChRs) in leukocytes. RT-PCR with alpha7 specific primers revealed the presence of the receptor mRNA in leukocytes. Immunoblotting and immunofluorescence experiments demonstrated the expression of a protein that is recognized by alpha7 specific antibodies. However, nicotine and acetylcholine (ACh) failed to elicit current in leukocytes. Binding experiments with alpha-bungarotoxin rhodamine conjugated were negative, illustrating the absence of a high-affinity binding site. RT-PCR analysis revealed the selective expression of the dupalpha7 mRNA. These data indicate that leukocytes express in their membrane the dupalpha7 protein but its physiological role remains to be identified.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Villiger Y,Szanto I,Jaconi S,Blanchet C,Buisson B,Krause KH,Bertrand D,Romand JA

doi

10.1016/s0165-5728(02)00057-7

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

86-98

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165572802000577

journal_volume

126

pub_type

杂志文章

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