Involvement of JAK/STAT signaling in the effect of cornel iridoid glycoside on experimental autoimmune encephalomyelitis amelioration in rats.

abstract：:The enzyme heme oxygenase-1 (HO-1) is reducing heme to the gaseous mediator carbon monoxide, to iron and the antioxidant biliverdin. The inducible expression of HO-1 is considered a protective cellular mechanism against reactive oxygen intermediates. Further, carbon monoxide (CO) is a regulator of cGMP synthesis, of N...

journal_title：Journal of neuroimmunology

authors： Schluesener HJ,Seid K

更新日期：2000-10-02 00:00:00

abstract：:The aim of the current review is to summarize the results of studies on the role of γδ T cells in the pathogenesis of multiple sclerosis and its animal model - the experimental autoimmune encephalomyelitis. Despite the fact that numerous studies have been performed, the role of γδ T is still not fully understood. It s...

journal_title：Journal of neuroimmunology

authors： Zarobkiewicz MK,Kowalska W,Roliński J,Bojarska-Junak AA

更新日期：2019-05-15 00:00:00

abstract：:Cellular adhesion molecules were initially defined as cell surface structures mediating cell-cell and cell-extracellular matrix (ECM) interactions. Adhesion molecules involved in immune responses have been classified into three families according to their structure: selectins, immunoglobulin (Ig) superfamily, and inte...

journal_title：Journal of neuroimmunology

authors： Lee SJ,Benveniste EN

更新日期：1999-08-03 00:00:00

abstract：:Neurocysticercosis (NC) presents two broad clinical entities: extraparenchymal (EP-NC) and parenchymal (P-NC). Using ELISA methodology, we demonstrate autoantibodies to tubulin and the Major oligodendrocyte glycoprotein (MOG) in the CSF of most, but not all, EP-NC samples. Levels of these autoantibodies were considera...

journal_title：Journal of neuroimmunology

authors： Parkhouse RME,Sciutto E,Hernández M,Cortez MM,Carpio A,Fleury A

更新日期：2020-12-15 00:00:00

abstract：:Neuroadapted Sindbis virus infection of mice causes T cell-mediated fatal encephalomyelitis. In the absence of IL-10, pathogenic Th17 cells are increased and disease is accelerated. Lymphoid and myeloid cell contributions to IL-10 production were determined using VertX IL-10 transcriptional eGFP reporter mice. Effecto...

journal_title：Journal of neuroimmunology

authors： Kulcsar KA,Griffin DE

更新日期：2016-06-15 00:00:00

abstract：:Experimental autoimmune neuritis (EAN), an autoimmune inflammatory demyelinating disease of the peripheral nervous system, represents an animal model of the human Guillain-Barré syndrome. EAN can be induced by active immunization in several animals, including Lewis rats. In contrast, most strains of mice including the...

journal_title：Journal of neuroimmunology

authors： Zhu J,Zou L,Zhu S,Mix E,Shi F,Wang H,Volkmann I,Winblad B,Schalling M,Ljunggren H

更新日期：2001-04-02 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is a cytokine with pleiotropic actions involved in the pathogenesis of autoimmune disorders, including Multiple Sclerosis (MS). We have first evaluated in silico the involvement of MIF, its homologue D-DT, and the receptors CD74, CD44, CXCR2 and CXCR4 in encephalitogenic T ...

journal_title：Journal of neuroimmunology

authors： Fagone P,Mazzon E,Cavalli E,Bramanti A,Petralia MC,Mangano K,Al-Abed Y,Bramati P,Nicoletti F

更新日期：2018-09-15 00:00:00

abstract：:Polymyositis (PM) is an inflammatory muscle disease caused by autoimmune dysfunction, considered to be caused by cytotoxic CD8 T cells. To date, no autoantigens have been identified. We attempted to induce an experimental allergic myositis (EAM) in BALB/c mice by inoculating syngeneic dendritic cells (DC) presenting p...

journal_title：Journal of neuroimmunology

authors： Kawachi I,Tanaka K,Tanaka M,Tsuji S

更新日期：2001-07-02 00:00:00

abstract：:Relative telomere length (TL) is regarded as a biomarker of biological age. Accelerated immune aging, as represented by TL reduction, has been demonstrated in autoimmune diseases, including multiple sclerosis (MS). However, it is still unresolved whether telomere shortening is the cause or the consequence of the patho...

journal_title：Journal of neuroimmunology

authors： Habib R,Ocklenburg S,Hoffjan S,Haghikia A,Epplen JT,Arning L

更新日期：2020-04-15 00:00:00

abstract：:An appropriate inflammatory response is crucial for the maintenance of tissue homeostasis. The inflammatory responses seen in the brain parenchyma differ from those elicited in the periphery, ventricles and meninges. However, although an inflammatory component has been associated with many CNS diseases, the difference...

journal_title：Journal of neuroimmunology

authors： Depino A,Ferrari C,Pott Godoy MC,Tarelli R,Pitossi FJ

更新日期：2005-11-01 00:00:00

abstract：:The blood brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCB) limit the influx of immune mediators and bloodstream compounds into the central nervous system (CNS). Upon injury or infection, the integrity of these barriers is compromised and leukocyte infiltration occurs. The BCB is located in the choro...

journal_title：Journal of neuroimmunology

authors： Alvarez JI,Teale JM

更新日期：2007-07-01 00:00:00

abstract：:The aberrant expression of B7 costimulatory molecules is involved in the pathogenesis of autoimmune diseases and overexpression of B7-1 was found in inflammatory multiple sclerosis (MS) lesions. We here report that costimulatory molecules B7-1 and B7-2 are expressed on cerebrospinal fluid (CSF) monocytes and B-lymphoc...

journal_title：Journal of neuroimmunology

authors： Windhagen A,Maniak S,Gebert A,Ferger I,Heidenreich F

更新日期：1999-04-01 00:00:00

abstract：:This study explores nasal administration of myelin basic protein (MBP) as a potential means of inducing tolerance to relapsing experimental autoimmune encephalomyelitis (PR-EAE), an experimental multiple sclerosis (MS) model that was induced in DA rats by immunization with rat spinal cord homogenate and incomplete Fre...

journal_title：Journal of neuroimmunology

authors： Bai XF,Shi FD,Xiao BG,Li HL,van der Meide PH,Link H

更新日期：1997-12-01 00:00:00

abstract：:Potential interactions between psychostimulant drugs and infection with feline immunodeficiency virus (FIV) on brain metabolism were evaluated. Four groups of cats were studied: control, FIV positive, methamphetamine (MA) exposed, and FIV positive plus MA exposed. Frontal gray matter, frontal white matter, and caudate...

journal_title：Journal of neuroimmunology

authors： Cloak CC,Chang L,Ernst T,Barr MC,Huitron-Resendiz S,Sanchez-Alavez M,Phillips TR,Henriksen S

更新日期：2004-02-01 00:00:00

abstract：:About two-thirds of the antibodies to the nicotinic acetylcholine receptor (AChR) in myasthenic patients, and in rats immunized with intact AChR, bind to the main immunogenic region (MIR) on the alpha-subunit. We tested all available anti-MIR monoclonal antibodies (mAbs) by competition experiments for binding on the i...

journal_title：Journal of neuroimmunology

authors： Kordossi AA,Tzartos SJ

更新日期：1989-06-01 00:00:00

abstract：:The capacity of rat cerebral endothelial cells (RCEC) to form eicosanoids was determined after incubation with 14C-labelled arachidonic acid. Prostaglandin E2 (PGE2) was the main metabolite formed by RCEC and was responsible for 54% of the total amount of eicosanoids produced. In contrast, in primary cultures of rat a...

journal_title：Journal of neuroimmunology

authors： de Vries HE,Hoogendoorn KH,van Dijk J,Zijlstra FJ,van Dam AM,Breimer DD,van Berkel TJ,de Boer AG,Kuiper J

更新日期：1995-06-01 00:00:00

abstract：:To investigate immune mechanisms in the etiology of idiopathic sensory neuronopathy (ISN), we studied neurite outgrowth inhibition and antibody binding to neuronal tissue of serum from 4 patients with ISN. Rat dorsal root ganglion (DRG) cells were cultured in the presence of serum from ISN patients and controls. After...

journal_title：Journal of neuroimmunology

authors： van Dijk GW,Wokke JH,Notermans NC,van den Berg LH,Bär PR

更新日期：1997-04-01 00:00:00

abstract：:We investigated potential therapeutic effects of sphingosine-1-phosphate (S1P) receptor modulators FTY720 (fingolimod) and selective S1P1 agonist SEW2871 on a spontaneous autoimmune polyneuropathy (SAP) when given orally at 7 mo (anticipated disease onset) for 4 weeks. Clinical severity, electrophysiologic and histolo...

journal_title：Journal of neuroimmunology

authors： Kim HJ,Jung CG,Dukala D,Bae H,Kakazu R,Wollmann R,Soliven B

更新日期：2009-09-29 00:00:00

abstract：:Complement-dependent disruption of motor endplate is detected in anti-acetylcholine receptor (AChR) antibody-positive myasthenia gravis (MG). We measured serum AChR α1 subunit protein levels, which may be associated with neuromuscular damage, in 55 patients with MG (47 were seropositive and 8 were negative) and in 20 ...

journal_title：Journal of neuroimmunology

authors： Uzawa A,Ozawa Y,Yasuda M,Oda F,Kojima Y,Kawaguchi N,Kanai T,Himuro K,Kuwabara S

更新日期：2020-02-15 00:00:00

abstract：:Interleukin-6 (IL-6) can activate gastrointestinal submucosal neurons, with associated implications for motility and secretory function. Patients with irritable bowel syndrome (IBS) have elevated levels of circulating IL-6. Colons from the Wistar Kyoto (WKY) rat model of IBS secrete more IL-6 (12.84 pg/ml) than contro...

journal_title：Journal of neuroimmunology

authors： O'Malley D,Dinan TG,Cryan JF

更新日期：2011-06-01 00:00:00

abstract：:Immunization with the whole cell pertussis vaccine (Pw), but not the acellular pertussis vaccine (Pa), is associated with a number of neurological side effects. Previously, we have demonstrated a role for interleukin-1beta (IL-1beta) in Pw reactogenicity. Here we report that parenteral Pw administration resulted in a ...

journal_title：Journal of neuroimmunology

authors： Armstrong ME,Loscher CE,Lynch MA,Mills KH

更新日期：2003-03-01 00:00:00

abstract：:The myelin basic protein (MBP)-like material (MBPLM) in human urine is expressed in a cryptic epitope(s) present in MBP peptide 80-89 and absent or inaccessible in intact MBP. These features of urinary MBPLM have made it difficult to produce reagents for its further characterization. Using an immunogen of keyhole limp...

journal_title：Journal of neuroimmunology

authors： Whitaker JN,McKeehan A,Freeman DW

更新日期：1994-06-01 00:00:00

abstract：:In 1996, we reported the results of a linkage genome screen based on 129 UK multiple sclerosis multiplex families, together with follow-up typing of interesting regions in a second set of families. We have now completed screening the remainder of the genome in this second set of United Kingdom families by typing 242 m...

journal_title：Journal of neuroimmunology

authors： Hensiek AE,Roxburgh R,Smilie B,Coraddu F,Akesson E,Holmans P,Sawcer SJ,Compston DA

更新日期：2003-10-01 00:00:00

abstract：:SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and Western blot of chick retinal proteins at 21 days after intravitreal injection with 5 or 10 microM/eye Glu showed decreases in 37, 42, 53 and 57 kDa proteins and increases in 35, 72 and >94 kDa proteins. These proteins were carboxylases except for the 35 and 37 kDa...

journal_title：Journal of neuroimmunology

authors： Sattayasai N,Sattayasai J,Daduang S,Chahomchuen T,Ketkaew S,Puchongkavarin H

更新日期：2003-08-01 00:00:00

abstract：:The presence of muscarinic acetylcholine receptors on lymphocytes has been demonstrated by radioligand binding experiments. Although the specific subtype(s) of muscarinic acetylcholine receptors expressed in lymphocytes is still unknown, some reports suggest the presence of the m2 subtype. In this study we analyzed th...

journal_title：Journal of neuroimmunology

authors： Costa P,Castoldi AF,Traver DJ,Costa LG

更新日期：1994-01-01 00:00:00

abstract：:Myelin-specific encephalitogenic T cells, when passively transferred into rats or mice, cause an experimental autoimmune disease. Previous studies by our group have shown that (a) the same cells also significantly reduce post-traumatic degeneration in these animals after injury to the central nervous system, (b) this ...

journal_title：Journal of neuroimmunology

authors： Kipnis J,Mizrahi T,Yoles E,Ben-Nun A,Schwartz M

更新日期：2002-09-01 00:00:00

abstract：:Acetylcholine receptor antibodies are very specific for myasthenia. During a large prospective cohort study of myasthenia, we encountered five patients, positive for acetylcholine receptor (AChR) antibodies by radioimmunoprecipitation assay (RIA), whose clinical course revealed diagnoses other than myasthenia. Two pat...

journal_title：Journal of neuroimmunology

authors： Maddison P,Sadalage G,Ambrose PA,Jacob S,Vincent A

更新日期：2019-07-15 00:00:00

abstract：:This study reports on the immunocytochemical localization of tumor necrosis factor-alpha (TNF alpha) in immune-mediated demyelination and Wallerian degeneration of the rat peripheral nervous system (PNS) using teased nerve fiber preparations. In experimental autoimmune neuritis induced by active immunization (EAN) or ...

journal_title：Journal of neuroimmunology

authors： Stoll G,Jung S,Jander S,van der Meide P,Hartung HP

更新日期：1993-06-01 00:00:00

abstract：:Experimental autoimmune myasthenia gravis (EAMG) was induced in rats by injection of purified acetylcholine receptor (AChR). In addition to detecting elevated serum titers of anti-AChR antibodies, we observed decreased twitch-tension at submaximal stimulation voltages and increased curare sensitivity by muscles obtain...

journal_title：Journal of neuroimmunology

authors： Olsberg CA,Maxwell LC,Mikiten TM,Krolick KA

更新日期：1987-04-01 00:00:00

abstract：:Human monoclonal IgM antibodies present in the blood of some patients with peripheral neuropathy and murine hybrid IgM antibodies C5 and C6, raised against myelin-associated glycoprotein, and HNK-1, raised against the human T cell line HSB-2, all bind to the carbohydrate moiety of myelin-associated glycoprotein. The r...

journal_title：Journal of neuroimmunology

authors： Miller SL,Kahn SN,Perussia B,Trinchieri G

更新日期：1987-07-01 00:00:00