当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration.

Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration.

Abstract：

:The mechanisms underlying in vivo activation of indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing enzyme that mediates in the brain the induction of depressive-like behavior by peripheral innate immune system stimulation are still poorly understood. By monitoring how cytokines parallel IDO mRNA expression in the brain in response to intraperitoneal lipopolysaccharide injection in mice, we report a time-dependent induction of IDO expression in both the hippocampus and hypothalamus that was associated with a specific structure-dependent expression of proinflammatory cytokines, particularly interferon-gamma. This study suggests that different mechanisms regulate the activation of IDO by lipopolysaccharide in various brain structures.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

André C,O'Connor JC,Kelley KW,Lestage J,Dantzer R,Castanon N

doi

10.1016/j.jneuroim.2008.06.011

subject

Has Abstract

pub_date

2008-08-30 00:00:00

pages

90-9

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(08)00226-9

journal_volume

200

pub_type

杂志文章

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