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Determination of interferon-gamma in the peripheral blood of multiple sclerosis patients in remission, using a chemiluminescence technique.

Abstract：

:The plasma from eight patients with multiple sclerosis (MS) whose disease was in remission, was investigated by a chemiluminescence technique for its ability to stimulate the oxidative metabolism of peripheral blood monocytes (PBM). The active fraction identified had a molecular weight between 13,700 and 43,000 Da. Its activity was reduced by incubation at pH 2, pH 4 or pH 6, or by treatment at 56 degrees C for 1-3 h. The activity was also decreased, 58-100%, by prior incubation with antibodies to human interferon-gamma (IFN-gamma). We suggest that these results indicate that the increased chemiluminescence activity (CL-A) of PBM in MS patients in remission is due mainly to the presence of circulating IFN-gamma.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Hammann KP,Hopf HC

doi

10.1016/0165-5728(86)90046-9

subject

Has Abstract

pub_date

1986-11-01 00:00:00

pages

9-18

issue

1

eissn

0165-5728

issn

1872-8421

pii

0165-5728(86)90046-9

journal_volume

13

pub_type

杂志文章

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