Abstract:
:M1 and M2 are the extremes of the differentiation spectrum of activated macrophages. Since microglia are members of the same cell lineage, we have characterized their transcription profile and their phagocytic activity under different conditions. LPS or IFN-gamma induce a M1-like phenotype, while IL-10 or IL-4 differentiate microglia towards a M2-deactivated or M2-alternatively-activated phenotype respectively. These differentiation processes also affect the Notch pathway. In order to study the polarization induced by Abeta, microglia was stimulated with different forms of the peptide. The oligomeric Abeta is a stronger M1-inductor than the fibrillar form. Moreover, a cytokine-induced anti-inflammatory environment reduces the microglial reactivity towards oligomeric Abeta.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Michelucci A,Heurtaux T,Grandbarbe L,Morga E,Heuschling Pdoi
10.1016/j.jneuroim.2009.02.003subject
Has Abstractpub_date
2009-05-29 00:00:00pages
3-12issue
1-2eissn
0165-5728issn
1872-8421pii
S0165-5728(09)00062-9journal_volume
210pub_type
杂志文章abstract::We evaluated the impact of brain MRI findings and oligoclonal IgG bands (OCBs) on conversion to clinically definite multiple sclerosis (CDMS) in 26 Japanese patients with clinically isolated syndrome (CIS). 19.2% had OCBs positivity and 3.8% had fulfillment of Barkhof criteria at baseline. 60.0% of CIS patients with p...
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journal_title:Journal of neuroimmunology
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journal_title:Journal of neuroimmunology
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:2012-05-15 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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journal_title:Journal of neuroimmunology
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:2004-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1993-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-06-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0165-5728(00)00213-7
更新日期:2000-07-01 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/j.jneuroim.2007.11.002
更新日期:2008-02-01 00:00:00
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journal_title:Journal of neuroimmunology
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更新日期:1991-04-01 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:2010-04-15 00:00:00
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journal_title:Journal of neuroimmunology
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章,评审
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:2006-09-01 00:00:00
abstract::To demonstrate the influence of n-3 PUFA supplementation on cytokine and eicosanoid production in peripheral blood mononuclear cells (PBMCs) of MS patients (MSP), we investigated the impact of a 6-month dietary supplementation with these fatty acids on the levels of interleukin-1 beta (IL-1 beta), IL-2, interferon-gam...
journal_title:Journal of neuroimmunology
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