RORγt, but not T-bet, overexpression exacerbates an autoimmune model for multiple sclerosis.

abstract：:Experimental autoimmune neuritis (EAN), an autoimmune inflammatory demyelinating disease of the peripheral nervous system, represents an animal model of the human Guillain-Barré syndrome. EAN can be induced by active immunization in several animals, including Lewis rats. In contrast, most strains of mice including the...

journal_title：Journal of neuroimmunology

authors： Zhu J,Zou L,Zhu S,Mix E,Shi F,Wang H,Volkmann I,Winblad B,Schalling M,Ljunggren H

更新日期：2001-04-02 00:00:00

abstract：:To test the hypothesis of an altered central nervous system influence upon the immune system of Down's syndrome (DS) patients and in order to establish a peripheral biological marker of neuroimmune deficit, we have studied the characteristics of the beta 2-adrenergic receptor (B2AR) system in peripheral blood monocyte...

journal_title：Journal of neuroimmunology

authors： Morale MC,Batticane N,Cioni M,Marchetti B

更新日期：1992-06-01 00:00:00

abstract：:We investigated in multiple sclerosis the difference between two commonly used oral and intravenous steroid regimens on the level of adhesion molecule expression on blood T lymphocytes, the distribution of circulating T cell subsets, and the concentration of serum tumour necrosis factor alpha. Venous blood samples wer...

journal_title：Journal of neuroimmunology

authors： Pitzalis C,Sharrack B,Gray IA,Lee A,Hughes RA

更新日期：1997-04-01 00:00:00

abstract：:The fourth member of the beta(2)-integrin family of adhesion molecules, CD11d (alpha(D)beta(2)), is expressed on a wide variety of immune cells, however its function in autoimmune diseases, including EAE remains unknown. We induced EAE in wild-type and CD11d(-/-) C57BL/6 mice using myelin oligodendrocyte glycoprotein ...

journal_title：Journal of neuroimmunology

authors： Adams JE,Webb MS,Hu X,Staunton D,Barnum SR

更新日期：2007-03-01 00:00:00

abstract：:Recent evidence that astrocytes can be induced to express the class II major histocompatability (MHC) antigens suggests that these cells may be involved in the development of intracerebral immune responses. The principal inducer of MHC class II antigen (Ia) expression is a soluble lymphokine, gamma-interferon (gamma-I...

journal_title：Journal of neuroimmunology

authors： Frohman EM,Vayuvegula B,van den Noort S,Gupta S

更新日期：1988-01-01 00:00:00

abstract：:Brain capillary endothelial cells are the component of blood brain barrier, and the first line of defense against viruses invading into brain. We demonstrate that treatment of hCMEC/D3 cells, a human brain capillary endothelial cell line, with a Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly...

journal_title：Journal of neuroimmunology

authors： Imaizumi T,Sassa N,Kawaguchi S,Matsumiya T,Yoshida H,Seya K,Shiratori T,Hirono K,Tanaka H

更新日期：2018-11-15 00:00:00

abstract：:We previously found increased microglial proliferation and pro-inflammatory cytokine release in infant mice compared to juvenile mice after hypoxia-ischemia (HI). The aim of the current study was to assess for differences in the effect of microglial suppression on HI-induced brain injury in infant and juvenile mice. H...

journal_title：Journal of neuroimmunology

authors： Cikla U,Chanana V,Kintner DB,Covert L,Dewall T,Waldman A,Rowley P,Cengiz P,Ferrazzano P

更新日期：2016-02-15 00:00:00

abstract：:The timing and intensity of the antibody responses to the marker determinants of synthetic peptide S81 and S82 sequences of bovine myelin basic protein (MBP) (residues 68-83 and 65-83, respectively) were studied in 20 Lewis rats and 6 rabbits. All rats immunized with either peptide in CFA responded with antibody devel...

journal_title：Journal of neuroimmunology

authors： Day ED,Hashim GA,Varitek VA Jr,Paterson PY

更新日期：1981-06-01 00:00:00

abstract：:The aim of this study was to investigate the humoral immune response to Borna disease (BD) virus in the brain of experimentally infected Lewis rats. Abundant IgG was detected in BD-rat brain with isotype variation throughout infection. IgG was locally produced as indicated by an intact blood-brain barrier, Ig kappa li...

journal_title：Journal of neuroimmunology

authors： Hatalski CG,Hickey WF,Lipkin WI

更新日期：1998-10-01 00:00:00

abstract：:In this study, we evaluated the role of the two functional HLA-DR heterodimers, DR2a (DR alpha paired with the beta chain encoded by DRB5*0101) and DR2b (DR alpha paired with the beta chain encoded by DRB1*1501), that are coexpressed in the multiple sclerosis (MS)-associated haplotype HLA-DR15 Dw2, in presenting myeli...

journal_title：Journal of neuroimmunology

authors： Vergelli M,Kalbus M,Rojo SC,Hemmer B,Kalbacher H,Tranquill L,Beck H,McFarland HF,De Mars R,Long EO,Martin R

更新日期：1997-08-01 00:00:00

abstract：:We have analyzed a CA repeat polymorphism localized 46-kb upstream of the Fas ligand gene in Spanish and American populations that include 139 healthy controls and a cohort of 177 unrelated relapsing and remitting multiple sclerosis (MS) patients. The MS patients consisted of two groups, one with a family history of M...

journal_title：Journal of neuroimmunology

authors： Zayas MD,Lucas M,Solano F,Fernández-Pérez MJ,Izquierdo G

更新日期：2001-06-01 00:00:00

abstract：:In this study, we analysed the recall antigen-induced cytokine production by peripheral blood mononuclear cells (PBMC) from 31 patients with multiple sclerosis (MS) with a relapsing-remitting (rr) and a relapsing-progressive (rp) course and from 40 healthy controls. Cells were stimulated with purified protein derivati...

journal_title：Journal of neuroimmunology

authors： Barth H,Klein K,Börtlein A,Guseo A,Berg PA,Wiethölter H,Klein R

更新日期：2002-12-01 00:00:00

abstract：:Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) is a well-characterized murine model of the chronic-progressive form of human multiple sclerosis (MS) characterized by the activation of myelin-specific autoreactive CD4 Th1 cells via epitope spreading. To gain an understanding of the po...

journal_title：Journal of neuroimmunology

authors： Mack CL,Vanderlugt-Castaneda CL,Neville KL,Miller SD

更新日期：2003-11-01 00:00:00

abstract：:Inflammatory mediators are involved in the pathogenesis of focal ischemic brain damage. In this study we used quantitative reverse transcriptase-polymerase chain reaction to analyze the spatiotemporal pattern of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and inducible nitric oxide synthase ...

journal_title：Journal of neuroimmunology

authors： Jander S,Schroeter M,Stoll G

更新日期：2000-09-22 00:00:00

abstract：:This report is to alert other investigators that Lewis rats, which are widely employed in studies of autoimmune diseases, vary considerably with respect to susceptibility to experimental autoimmune encephalomyelitis (EAE), depending upon commercial source. ...

journal_title：Journal of neuroimmunology

authors： Gould KE,Stepaniak JA,Swanborg RH

更新日期：1994-10-01 00:00:00

abstract：:The NF-κB signalling pathway plays an important role in controlling cellular immune responses, inflammation and apoptosis. In multiple sclerosis (MS), there is evidence of dysregulation of NF-κB signalling in patients with a relapsing-remitting disease course, but thus far there is little information on whether it is ...

journal_title：Journal of neuroimmunology

authors： Yan J,Winterford CM,Catts VS,Pat BK,Pender MP,McCombe PA,Greer JM

更新日期：2018-07-15 00:00:00

abstract：:Strong expression of class II major histocompatibility (MHC II, Ia) antigens was observed in areas of Wallerian degeneration following either a cryoinjury to the cerebral and cerebellar cortex or unilateral eye enucleation in adult Wistar and Lewis rats. The Wallerian degeneration was disclosed by the Fink-Heimer meth...

journal_title：Journal of neuroimmunology

authors： Konno H,Yamamoto T,Iwasaki Y,Suzuki H,Saito T,Terunuma H

更新日期：1989-12-01 00:00:00

abstract：:B cells are of increasing importance as a target for multiple sclerosis treatment. Here we show that GA treatment of mice with experimental autoimmune encephalomyelitis (EAE) biases cytokine production by B cells towards cytokines associated with regulation in MS including interleukin (IL)-4, -10 and -13 and reduces p...

journal_title：Journal of neuroimmunology

authors： Begum-Haque S,Sharma A,Christy M,Lentini T,Ochoa-Reparaz J,Fayed IF,Mielcarz D,Haque A,Kasper LH

更新日期：2010-02-26 00:00:00

abstract：:Interferon-β (IFN-β) is known to expand regulatory CD56(bright) natural killer (NK) cells in multiple sclerosis (MS). In this cross-sectional study we show that MS patients treated with IFN-β alone or in combination with low-dose prednisolone displayed increased proportion of all NK cell subsets in the active phase of...

journal_title：Journal of neuroimmunology

authors： Sanvito L,Tomita A,Chihara N,Okamoto T,Lin Y,Ogawa M,Gran B,Aranami T,Yamamura T

更新日期：2011-07-01 00:00:00

abstract：:The blood brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCB) limit the influx of immune mediators and bloodstream compounds into the central nervous system (CNS). Upon injury or infection, the integrity of these barriers is compromised and leukocyte infiltration occurs. The BCB is located in the choro...

journal_title：Journal of neuroimmunology

authors： Alvarez JI,Teale JM

更新日期：2007-07-01 00:00:00

abstract：:Light and electron immunocytochemistry using antibodies recognising a class II major histocompatibility complex antigen, fibrin, fibronectin, albumin and factor VIII related antigen has been used to stain sections of spinal cord from normal guinea pigs and those with chronic relapsing experimental allergic encephalomy...

journal_title：Journal of neuroimmunology

authors： Butter C,Healey DG,Agha N,Wilcox CE,Antoniou AV,Turk JL

更新日期：1989-03-01 00:00:00

abstract：:The pathogenesis of Guillain-Barré Syndrome (GBS) is not entirely understood, but includes infection-induced aberrant immune responses. Genetic polymorphisms in Fc gamma receptor genes (FCGR) have been associated with GBS. We assessed whether polymorphisms rs1801274 in FCGR2A and rs396991 in FCGR3A were associated wit...

journal_title：Journal of neuroimmunology

authors： Dourado ME Junior,Ferreira LC,Freire-Neto FP,Jeronimo SM

更新日期：2016-09-15 00:00:00

abstract：:We reviewed the records of 391 patients who had presented with a Clinically Isolated Syndrome and selected 205 who had performed a baseline spinal tap and MRI scan. We studied cerebrospinal fluid (CSF) and serum IgM oligoclonal bands (IgMOB) using agarose gel isoelectric focusing and analyzed the impact of baseline cl...

journal_title：Journal of neuroimmunology

authors： Ferraro D,Simone AM,Bedin R,Galli V,Vitetta F,Federzoni L,D'Amico R,Merelli E,Nichelli PF,Sola P

更新日期：2013-04-15 00:00:00

abstract：:A high proportion of peptide 1-11 specific T cells from H-2u (V beta 8+, H-2u) mice express the V beta 8 TCR chain. Peptide 89-101 is immunodominant for B10.RIII (V beta 8+, H-2r) mice; thus, it was of interest to determine whether V beta 8 TCR would be over-represented in a population of peptide 89-101-specific T cel...

journal_title：Journal of neuroimmunology

authors： Zhao ML,Xia JQ,Fritz RB

更新日期：1993-02-01 00:00:00

abstract：:We compared the expression of various interferon-gamma (IFN-gamma)-inducible mRNAs in primary rat astrocytes and microglia. Of 11 different mRNAs inducible by IFN-gamma in a macrophage cell line, RAW 264.7, only eight were induced in both types of glia, which included mRNAs encoding the transcriptional factors, IRF-1,...

journal_title：Journal of neuroimmunology

authors： Vanguri P

更新日期：1995-01-01 00:00:00

abstract：:The plasma from eight patients with multiple sclerosis (MS) whose disease was in remission, was investigated by a chemiluminescence technique for its ability to stimulate the oxidative metabolism of peripheral blood monocytes (PBM). The active fraction identified had a molecular weight between 13,700 and 43,000 Da. It...

journal_title：Journal of neuroimmunology

authors： Hammann KP,Hopf HC

更新日期：1986-11-01 00:00:00

abstract：:We report here the results of a phase I trial of a T-cell receptor (TCR) V beta 6 CDR2 region peptide vaccine in 10 patients with multiple sclerosis who showed biased over-representations of V beta 6 mRNA among T-cells in their cerebrospinal fluids (CSF). One group of 5 patients was immunized twice during a four week ...

journal_title：Journal of neuroimmunology

authors： Gold DP,Smith RA,Golding AB,Morgan EE,Dafashy T,Nelson J,Smith L,Diveley J,Laxer JA,Richieri SP,Carlo DJ,Brostoff SW,Wilson DB

更新日期：1997-06-01 00:00:00

abstract：:Human cytomegalovirus (CMV) infection is asymptomatic in immunocompetent individuals. However, it can lead to disease in immunodeficient population. Little is known of the mechanisms underlying the pathogenicity of the virus. We investigated the impact of CMV infection on mouse nervous system. Peripheral nerves but no...

journal_title：Journal of neuroimmunology

authors： Oladiran O,Yang M,Rivera VAG,Shi X,Huang J,Fournier S,Zhang J

更新日期：2019-10-15 00:00:00

abstract：:The pathogenesis of Alzheimer's disease (AD) includes the participation of the immune system. To identify antigenic targets in AD, we screened a human microvascular endothelial cell cDNA library with sera from patients with AD, and we identified rabaptin 5 (RABPT5). We detected serum IgG specific to RABPT5 in 65% of p...

journal_title：Journal of neuroimmunology

authors： Delunardo F,Margutti P,Pontecorvo S,Colasanti T,Conti F,Riganò R,Profumo E,Siracusano A,Capozzi A,Prencipe M,Sorice M,Francia A,Ortona E

更新日期：2007-12-01 00:00:00

abstract：:The presence of pre-existing natural antibodies against Alzheimer's disease (AD) pathological proteins might interfere with immune responses to therapeutic vaccination with these proteins. We aimed to compare levels of antibodies in CSF and serum: We observed higher reactivity of natural tau-reactive antibodies toward...

journal_title：Journal of neuroimmunology

authors： Krestova M,Ricny J,Bartos A

更新日期：2018-09-15 00:00:00