The localisation of fibrin, fibronectin and class II major histocompatibility complex antigen in the spinal cord in chronic relapsing experimental allergic encephalomyelitis.

Abstract:

:Light and electron immunocytochemistry using antibodies recognising a class II major histocompatibility complex antigen, fibrin, fibronectin, albumin and factor VIII related antigen has been used to stain sections of spinal cord from normal guinea pigs and those with chronic relapsing experimental allergic encephalomyelitis (CREAE). It was found that class II MHC antigens, fibrin and fibronectin were present in normal blood vessels and at high levels in lesions from animals at all stages of the disease. The possible immunological roles of these antigens suggest their participation in the initiation and maintenance of disease state.

journal_name

J Neuroimmunol

authors

Butter C,Healey DG,Agha N,Wilcox CE,Antoniou AV,Turk JL

doi

10.1016/0165-5728(89)90003-9

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

11-7

issue

1

eissn

0165-5728

issn

1872-8421

pii

0165-5728(89)90003-9

journal_volume

22

pub_type

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