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Increase of Ki-67+ natural killer cells in multiple sclerosis patients treated with interferon-β and interferon-β combined with low-dose oral steroids.

Abstract：

:Interferon-β (IFN-β) is known to expand regulatory CD56(bright) natural killer (NK) cells in multiple sclerosis (MS). In this cross-sectional study we show that MS patients treated with IFN-β alone or in combination with low-dose prednisolone displayed increased proportion of all NK cell subsets in the active phase of the cell cycle (Ki-67+). There was no difference in NK cell apoptosis markers. In vitro experiments showed that both IFN-β and IFN-β in combination with corticosteroids increased the proportion of Ki-67(+) NK cells. This study, although limited, shows that treatment with IFN-β affects NK cell cycle without altering NK cell apoptosis in MS patients.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Sanvito L,Tomita A,Chihara N,Okamoto T,Lin Y,Ogawa M,Gran B,Aranami T,Yamamura T

doi

10.1016/j.jneuroim.2011.05.005

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

111-7

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(11)00134-2

journal_volume

236

pub_type

杂志文章

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