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Interferon-stimulated gene 60 (ISG60) constitutes a negative feedback loop in the downstream of TLR3 signaling in hCMEC/D3 cells.

Abstract：

:Brain capillary endothelial cells are the component of blood brain barrier, and the first line of defense against viruses invading into brain. We demonstrate that treatment of hCMEC/D3 cells, a human brain capillary endothelial cell line, with a Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly IC) induces the expression of interferon (IFN)-stimulated gene 60 (ISG60), and this reaction was mediated by IFN-β. Knockdown of ISG60 increased the poly IC-induced expression of IFN-β and an IFN-β-inducible chemokine CXCL10. This indicates that ISG60 constitutes a negative feedback loop in the downstream of TLR3/IFN-β. ISG60 in brain capillary endothelial cells may contribute to prevent excess immune reactions associated with viral infections.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Imaizumi T,Sassa N,Kawaguchi S,Matsumiya T,Yoshida H,Seya K,Shiratori T,Hirono K,Tanaka H

doi

10.1016/j.jneuroim.2018.08.016

subject

Has Abstract

pub_date

2018-11-15 00:00:00

pages

16-21

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(18)30245-5

journal_volume

324

pub_type

杂志文章

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