Spectratype analysis of clonal T cell expansion in murine experimental stroke.

abstract：:We have established a mouse experimental brain abscess model using Staphylococcus aureus where lesion sites are greatly exaggerated compared to the localized area of initial infection, reminiscent of an overactive immune response. Here we demonstrate the prolonged expression of IL-1 beta, TNF-alpha, and macrophage inf...

journal_title：Journal of neuroimmunology

authors： Baldwin AC,Kielian T

更新日期：2004-06-01 00:00:00

abstract：:Laquinimod, is a potential oral immunomodulatory drug, for relapsing-remitting multiple sclerosis (RRMS). We analyzed the blood-transcriptional changes in RRMS patients (who participated in the ALLEGRO clinical trial) at one and six months after laquinimod treatment using gene expression microarrays. The molecular eff...

journal_title：Journal of neuroimmunology

authors： Zilkha-Falb R,Gurevich M,Hayardeny L,Achiron A

更新日期：2015-06-15 00:00:00

abstract：:A cross-reactive idiotope (CRI) has been previously described on monoclonal antibodies (mAbs) specific for encephalitogenic peptides from myelin basic protein (MBP). The anti-CRI mAb, F25F7, binds an idiotope (Id) localized to the light chains of an anti-MBP peptide 1-9 mAb, denoted F23C6, and an anti-MBP peptide 80-8...

journal_title：Journal of neuroimmunology

authors： Maier CC,LeBoeuf RD,Zhou SR,Whitaker JN,Jarpe MA,Blalock JE

更新日期：1993-07-01 00:00:00

abstract：:In this study we aimed to investigate whether treatment with an immune modulatory drug had an effect on the distribution of B cell subpopulations in patients with remitting-relapsing multiple sclerosis (RRMS). We investigated the first-line drugs glatiramer acetate, interferon-β and natalizumab. Our data show that the...

journal_title：Journal of neuroimmunology

authors： Rovituso D,Heller S,Schroeter M,Kleinschnitz C,Kuerten S

更新日期：2014-07-15 00:00:00

abstract：:Guillain-Barré syndrome (GBS) is an acute inflammatory autoimmune disease affecting the peripheral nervous system. MicroRNAs (miRNAs) are a class of small noncoding RNAs that play critical roles in the process of various diseases. The miRNAs in GBS were less studied. In this study, using microarray technology, we foun...

journal_title：Journal of neuroimmunology

authors： Lv Z,Shi Q,Huang W,Xing C,Hao Y,Feng X,Yang Y,Zhang A,Kong Q,Yuki N,Wang Y

更新日期：2016-12-15 00:00:00

abstract：:Studies on patients with monosymptomatic optic neuritis (ON) should give opportunities to identify features typical for early multiple sclerosis (MS). There are increased T and B cell responses to the myelin components myelin basic protein (MBP) and proteolipid protein (PLP) in both ON and MS, but there is little info...

journal_title：Journal of neuroimmunology

authors： Link J,Söderström M,Kostulas V,Olsson T,Höjeberg B,Ljungdahl A,Link H

更新日期：1994-01-01 00:00:00

abstract：:Macrophages are considered to be the predominant effector cells in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Ultra small particles of iron oxide (USPIO) can be used to detect macrophage infiltrates in the CNS with magnetic resonance imaging (MRI). Here, we investigat...

journal_title：Journal of neuroimmunology

authors： Baeten K,Hendriks JJ,Hellings N,Theunissen E,Vanderlocht J,Ryck LD,Gelan J,Stinissen P,Adriaensens P

更新日期：2008-03-01 00:00:00

abstract：:H-2 class I antigens, but not class II antigens, were detected on the surface of glial cells persistently infected with mouse hepatitis virus strain A59 (MHV-A59) as late as 90 days post-infection. Uninfected glial cells remained negative for H-2 class I and class II surface antigens. We have previously shown that con...

journal_title：Journal of neuroimmunology

authors： Lavi E,Suzumura A,Murray EM,Silberberg DH,Weiss SR

更新日期：1989-04-01 00:00:00

abstract：:Plasma B cells secrete immunoglobulinfree light chains (IgLC) which by binding to mast cells can mediate hypersensitivity responses and are involved in several immunological disorders. To investigate the effects of antigen-specific IgLC activation, intracellular recordings were made from cultured murine dorsal root ga...

journal_title：Journal of neuroimmunology

authors： Rijnierse A,Kraneveld AD,Salemi A,Zwaneveld S,Goumans AP,Rychter JW,Thio M,Redegeld FA,Westerink RH,Kroese AB

更新日期：2013-11-15 00:00:00

abstract：:Clinical and experimental studies with LPS injection have shown an increase in vasopressin (AVP) secretion in the early phase of severe sepsis, which is subsequently reduced despite persistent hypotension. The aim of this study was to evaluate the role of inducible nitric oxide synthase (iNOS)-derived NO in hypothalam...

journal_title：Journal of neuroimmunology

authors： Corrêa PB,Pancoto JA,de Oliveira-Pelegrin GR,Cárnio EC,Rocha MJ

更新日期：2007-02-01 00:00:00

abstract：:Administration of beta-receptor agonists alleviate experimental multiple sclerosis (MS) in animal models. In this study, we investigated the effects of terbutaline (5 mg) on IL-10, IL-12, IFN-gamma and TNF-alpha production in whole blood stimulation cultures. IL-10 and IL-12 production were significantly enhanced in c...

journal_title：Journal of neuroimmunology

authors： Heesen C,Gold SM,Sondermann J,Tessmer W,Schulz KH

更新日期：2002-11-01 00:00:00

abstract：:To elucidate whether density of cells could contribute to the extent of microglial activation, we performed in vitro assays using three different densities of N13 microglia stimulated with LPS. Our results showed that induction of pro-inflammatory factors as TNF-α and iNOS was directly related to cell density, meanwhi...

journal_title：Journal of neuroimmunology

authors： Pintado C,Revilla E,Vizuete ML,Jiménez S,García-Cuervo L,Vitorica J,Ruano D,Castaño A

更新日期：2011-09-15 00:00:00

abstract：:Increased plasma levels of interleukin-6 (IL-6) in response to acute hypoglycemia have been well documented. Aiming to study the interaction between IL-6 and counter-regulatory hormones during hypoglycemic stress we conducted an exploratory single center study involving 26 adult patients undergoing insulin tolerance t...

journal_title：Journal of neuroimmunology

authors： Drummond JB,Soares BS,Vieira ELM,Pedrosa W,Teixeira AL,Ribeiro-Oliveira A Jr

更新日期：2020-11-13 00:00:00

abstract：:A new technique for a conglutinin ELISA using a microtiter plate has been developed for measuring circulating immune complexes. The sensitivity of our system ranges between 0.2 and 3.2 micrograms equivalents of aggregated human IgG. We have applied this system to 21 normal healthy controls and 80 neurological patients...

journal_title：Journal of neuroimmunology

authors： Araga S,Irie H,Takahashi K

更新日期：1984-06-01 00:00:00

abstract：:A chemiluminescence assay was developed based on the interaction between antibodies binding to the surface of living brain cells in culture and macrophages. Such interaction leads to production of reactive oxygen radicals which can be measured by a chemiluminescence assay. This assay was used to detect anti brain anti...

journal_title：Journal of neuroimmunology

authors： Brügger M,Dayrell-Hart E,Meier C,Vandevelde M,Zurbriggen A

更新日期：1994-01-01 00:00:00

abstract：:Lewis rats were treated from day of birth with a rabbit anti-rat IgM antiserum. As adults these animals were found to have no detectable serum IgM and greatly reduced levels of IgG. They failed to respond to the B-cell mitogen LPS, or to make antibodies to sheep red blood cells (SRBC) or myelin basic protein (BP). The...

journal_title：Journal of neuroimmunology

authors： Willenborg DO,Prowse SJ

更新日期：1983-10-01 00:00:00

abstract：PURPOSE:It will provide a reference for early detection, early diagnosis and early treatment of atypical primary Sjogren syndrome with neurological impairment as the first symptom. METHODS:Case report and Literature review. RESULTS:Here we report a 30-year-old woman diagnosed with trigeminal damage secondary to pSS w...

journal_title：Journal of neuroimmunology

authors： Yuan J,Gong L,Wu H,Chen Q,Wang J,Chen W,Wang X,Ren C

更新日期：2018-11-15 00:00:00

abstract：:In the present study, circulating proportions of CD8(+) T (Tc) cell subsets, including IL-17 (Tc17) and IL-10 (Tc10) producing cells, were assessed in relapsing-remitting MS (RRMS) patients and a possible effect of beta interferon (IFN-β), glatiramer acetate (GA), and vitamin D (VitD) on these cell subsets was investi...

journal_title：Journal of neuroimmunology

authors： Peelen E,Thewissen M,Knippenberg S,Smolders J,Muris AH,Menheere P,Tervaert JW,Hupperts R,Damoiseaux J

更新日期：2013-05-15 00:00:00

abstract：:This study explores the consequences of deficiency in the autoimmune regulator (Aire) on the susceptibility to experimental autoimmune encephalomyelitis (EAE). Increased susceptibility to EAE was found in Aire knockout (KO) compared to wild type (WT) in 6month old mice. In contrast, 2month old Aire KO mice were less s...

journal_title：Journal of neuroimmunology

authors： Aharoni R,Aricha R,Eilam R,From I,Mizrahi K,Arnon R,Souroujon MC,Fuchs S

更新日期：2013-09-15 00:00:00

abstract：:Anti-galactocerebroside (GalC) antibodies are reported to be present in GBS patients with preceding Mycoplasma pneumoniae (MP) infection. We investigated the presence of anti-GalC reactivity in serum of a large group of GBS patients using ELISA and compared this with healthy controls and individuals with an uncomplica...

journal_title：Journal of neuroimmunology

authors： Ang CW,Tio-Gillen AP,Groen J,Herbrink P,Jacobs BC,Van Koningsveld R,Osterhaus AD,Van der Meché FG,van Doorn PA

更新日期：2002-09-01 00:00:00

abstract：:HIV-induced neurological disease is postulated to be caused by indirect mechanisms. Tumor necrosis factor (TNF)alpha is increased in the brains in human immunodeficiency virus (HIV)-associated dementia and in the spinal cord in vacuolar myelopathy and may play a pathogenetic role in these diseases. Microglia, astrocyt...

journal_title：Journal of neuroimmunology

authors： Wesselingh SL,Takahashi K,Glass JD,McArthur JC,Griffin JW,Griffin DE

更新日期：1997-04-01 00:00:00

abstract：:In the present study, we investigated the therapeutic benefit of cornel iridoid glycoside (CIG), the main component extracted from Cornus officinalis, in experimental autoimmune encephalomyelitis (EAE) rats. CIG was intragastrically administered daily after EAE initiation for 20days and reduced disease severity, incid...

journal_title：Journal of neuroimmunology

authors： Yin L,Chen Y,Qu Z,Zhang L,Wang Q,Zhang Q,Li L

更新日期：2014-09-15 00:00:00

abstract：:Microglia cells are the principal immune effector elements of the brain responding to any pathological event. To elucidate the possible role of microglia in initial non-inflammatory demyelination in canine distemper virus (CDV) infection, microglia from experimentally CDV infected dogs were isolated ex vivo by density...

journal_title：Journal of neuroimmunology

authors： Stein VM,Czub M,Schreiner N,Moore PF,Vandevelde M,Zurbriggen A,Tipold A

更新日期：2004-08-01 00:00:00

abstract：:A technique is described which allows the detection of virus-specific oligoclonal IgG in unconcentrated cerebrospinal fluid (CSF) from patients with virus infections of the central nervous system. CSF is isoelectrically focused in agarose gels and immunoglobulins are blotted to nitrocellulose filters, passively loaded...

journal_title：Journal of neuroimmunology

authors： Dörries R,Ter Meulen V

更新日期：1984-12-01 00:00:00

abstract：:Resident glial cells and invading inflammatory cells are responsible for cytokine production within the brain. Astrocytes are known to secrete a variety of cytokines upon stimulation with cytokines themselves, protein kinase C activators, bacterial or viral constituents. Astrocytes also have surface receptors for a wi...

journal_title：Journal of neuroimmunology

authors： Maimone D,Cioni C,Rosa S,Macchia G,Aloisi F,Annunziata P

更新日期：1993-08-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) was induced in Lewis rats by inoculation with myelin basic protein (MBP) and adjuvants. Rats were treated with second daily injections of saline or cyclosporin A (CsA) from the day of inoculation. Saline-treated rats had an acute episode of disease followed by clinical r...

journal_title：Journal of neuroimmunology

authors： McCombe PA,Harness J,Pender MP

更新日期：1999-06-01 00:00:00

abstract：:We studied the effect of interferons on the expression of class II histocompatibility (HLA-DR) antigens by cultured adult human astrocytes. Cultures were derived from brain tissue resected for surgical treatment of intractable epilepsy. Cultured astrocytes did not spontaneously display HLA-DR antigen as determined by ...

journal_title：Journal of neuroimmunology

authors： Barna BP,Chou SM,Jacobs B,Yen-Lieberman B,Ransohoff RM

更新日期：1989-06-01 00:00:00

abstract：:Stroke may be accompanied by immunological consequences including local autoimmunity and peripheral immune suppression. Since the blood brain barrier is disturbed cells of the immune system gain direct access to the brain parenchyma. Here local autoimmunity contributes to lesion formation and, in experimental stroke, ...

journal_title：Journal of neuroimmunology

authors： Vogelgesang A,Dressel A

更新日期：2011-02-01 00:00:00

abstract：:Glutamate, an excitatory neurotransmitter, is neurotoxic at high concentrations. Neuroglial cells, including astrocytes and microglia, play an important role in regulating its extracellular levels. Cultured human monocytic THP-1 cells increased their glutamate secretion following 18 and 68 h exposure to the inflammato...

journal_title：Journal of neuroimmunology

authors： Klegeris A,Walker DG,McGeer PL

更新日期：1997-09-01 00:00:00

abstract：:Mast cells are normally found adjacent to blood vessels in the nervous system, and have been implicated in the development of inflammatory central nervous system (CNS) diseases such as experimental allergic encephalomyelitis. To further study mast cell-CNS interactions, we have developed a model in which viable rat pe...

journal_title：Journal of neuroimmunology

authors： Seeldrayers PA,Levin LA,Johnson D

更新日期：1992-02-01 00:00:00