Oral terbutaline differentially affects cytokine (IL-10, IL-12, TNF, IFNg) release in multiple sclerosis patients and controls.

Abstract:

:Administration of beta-receptor agonists alleviate experimental multiple sclerosis (MS) in animal models. In this study, we investigated the effects of terbutaline (5 mg) on IL-10, IL-12, IFN-gamma and TNF-alpha production in whole blood stimulation cultures. IL-10 and IL-12 production were significantly enhanced in controls but not in MS patients (p=0.03 and p=0.001). Effects were not associated with an ongoing immunomodulatory therapy. We conclude that administration of terbutaline induces anti-inflammatory (IL-10) as well as IL-12 protein production in healthy controls but not in MS patients. Our findings might reflect a disturbed autonomic control of the immune system in MS.

journal_name

J Neuroimmunol

authors

Heesen C,Gold SM,Sondermann J,Tessmer W,Schulz KH

doi

10.1016/s0165-5728(02)00322-3

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

189-95

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165572802003223

journal_volume

132

pub_type

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