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Age dependent course of EAE in Aire-/- mice.

Abstract：

:This study explores the consequences of deficiency in the autoimmune regulator (Aire) on the susceptibility to experimental autoimmune encephalomyelitis (EAE). Increased susceptibility to EAE was found in Aire knockout (KO) compared to wild type (WT) in 6month old mice. In contrast, 2month old Aire KO mice were less susceptible to EAE than WT mice, and this age-related resistance correlated with elevated proportions of T regulatory (Treg) cells in their spleen and brain. Combined with our previous findings in experimental autoimmune myasthenia gravis, we suggest an age-related association between Aire and Treg cells in the susceptibility to autoimmunity.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Aharoni R,Aricha R,Eilam R,From I,Mizrahi K,Arnon R,Souroujon MC,Fuchs S

doi

10.1016/j.jneuroim.2013.06.001

subject

Has Abstract

pub_date

2013-09-15 00:00:00

pages

27-34

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(13)00160-4

journal_volume

262

pub_type

杂志文章

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