Chemokine CXCL8 modulates GluR1 phosphorylation.

abstract：:In the present work we investigated on rat splenocytes long-term interactions between opioid and cannabinoid drugs in terms of a common regulation of cAMP intracellular pathway. Both morphine and the synthetic cannabinoid compound CP-55,940 inhibited in a concentration-dependent manner the intracellular cAMP level in ...

journal_title：Journal of neuroimmunology

authors： Massi P,Vaccani A,Rubino T,Parolaro D

更新日期：2003-12-01 00:00:00

abstract：:Antigen presentation, a key mechanism in immune responses, involves two main signals: the first is provided by the engagement of a major histocompatibility complex (MHC), class I or class II, with their TCR receptor in lymphocytes, whereas the second demands the participation of different co-stimulatory molecules, suc...

journal_title：Journal of neuroimmunology

authors： Almolda B,González B,Castellano B

更新日期：2010-06-01 00:00:00

abstract：:Experimental autoimmune neuritis (EAN) is an inflammatory autoimmune demyelinating disease of the peripheral nervous system (PNS) and represents an animal model of Guillain-Barré syndrome (GBS), which is a major inflammatory demyelinating disease of the PNS in humans. In the present study, the dynamics of the expressi...

journal_title：Journal of neuroimmunology

authors： Zou LP,Pelidou SH,Abbas N,Deretzi G,Mix E,Schaltzbeerg M,Winblad B,Zhu J

更新日期：1999-08-03 00:00:00

abstract：:Little is known regarding protein responses to syphilis infection in cerebrospinal fluid (CSF) of patients presenting with neurosyphilis. Protein and antibody arrays offer a new opportunity to gain insights into global protein expression profiles in these patients. Here we obtained CSF samples from 46 syphilis patient...

journal_title：Journal of neuroimmunology

authors： Lu P,Zheng DC,Fang C,Huang JM,Ke WJ,Wang LY,Zeng WY,Zheng HP,Yang B

更新日期：2016-04-15 00:00:00

abstract：:In order to study the role of interleukin-1beta (IL-1beta) in homeostasis, hypoxia and recovery of neuronal cells, we studied the expression and release of tumor necrosis factor-alpha (TNF-alpha) and nerve growth factor (NGF), in relation to the presence or absence of this cytokine in culture medium. Moreover, we eval...

journal_title：Journal of neuroimmunology

authors： Di Loreto S,Corvetti L,Maccarone R,Piancatelli D,Adorno D

更新日期：2000-07-01 00:00:00

abstract：:Rasmussen's encephalitis (RE) is a rare condition characterized by drug-resistant seizures, recurrent status epilepticus and progressive lateralized neurological deterioration. There is evidence of autoimmune involvement in the pathogenesis. We investigated the presence of anti-GluR3 antibodies against peptides A and ...

journal_title：Journal of neuroimmunology

authors： Mantegazza R,Bernasconi P,Baggi F,Spreafico R,Ragona F,Antozzi C,Bernardi G,Granata T

更新日期：2002-10-01 00:00:00

abstract：:To clarify the origin and function of the microglia residing in the central nervous system, we cloned brain cells from newborn and adult mice in soft agar containing the macrophage-specific growth factor, colony-stimulating factor-1 and expanded the cells from individual colonies in liquid culture medium. The results ...

journal_title：Journal of neuroimmunology

authors： Moore SC,McCormack JM,Armendariz E,Gatewood J,Walker WS

更新日期：1992-12-01 00:00:00

abstract：:Multiple sclerosis (MS) is an immune-mediated demyelinating disease that could be triggered by a viral infection. Coronaviruses induce an MS-like disease in rodents, are neuroinvasive in humans and can infect primary cultures of human astrocytes and microglia. Infection of the human astrocytic cell line U-373MG by the...

journal_title：Journal of neuroimmunology

authors： Edwards JA,Denis F,Talbot PJ

更新日期：2000-08-01 00:00:00

abstract：:Zymosan has previously been reported to have both pro-inflammatory and anti-inflammatory effects. Here we demonstrate that low dose zymosan prevented or reversed chronic and relapsing paralysis in EAE. In suppressing CNS autoimmune inflammation, zymosan not only regulated APC costimulator and MHC class II expression, ...

journal_title：Journal of neuroimmunology

authors： Li H,Gonnella P,Safavi F,Vessal G,Nourbakhsh B,Zhou F,Zhang GX,Rostami A

更新日期：2013-01-15 00:00:00

abstract：:The 802-2 peptide, designed from the conserved D1-CC' loop region of human CD4, can disrupt CD4(+) T cell activation in both human and murine systems. Here, 802-2 was investigated for efficacy in acute murine experimental allergic encephalomyelitis (EAE) models, and was found to significantly reduce the severity of di...

journal_title：Journal of neuroimmunology

authors： Edling AE,Choksi S,Huang Z,Korngold R

更新日期：2001-01-01 00:00:00

abstract：:Recent evidence that astrocytes can be induced to express the class II major histocompatability (MHC) antigens suggests that these cells may be involved in the development of intracerebral immune responses. The principal inducer of MHC class II antigen (Ia) expression is a soluble lymphokine, gamma-interferon (gamma-I...

journal_title：Journal of neuroimmunology

authors： Frohman EM,Vayuvegula B,van den Noort S,Gupta S

更新日期：1988-01-01 00:00:00

abstract：:We have analyzed a CA repeat polymorphism localized 46-kb upstream of the Fas ligand gene in Spanish and American populations that include 139 healthy controls and a cohort of 177 unrelated relapsing and remitting multiple sclerosis (MS) patients. The MS patients consisted of two groups, one with a family history of M...

journal_title：Journal of neuroimmunology

authors： Zayas MD,Lucas M,Solano F,Fernández-Pérez MJ,Izquierdo G

更新日期：2001-06-01 00:00:00

abstract：:This study investigated whether anti-CD40 Ab and 8-oxo-dG attenuate mast cell migration and EAE development. Anti-CD40 Ab and 8-oxo-dG reduced EAE scores, mast cell numbers, expression of adhesion molecules, OX40L and Act1, levels of TNF-α, LTs, expression of cytokines, and co-localization of Treg cells and mast cells...

journal_title：Journal of neuroimmunology

authors： Hong GU,Kim NG,Jeoung D,Ro JY

更新日期：2013-07-15 00:00:00

abstract：:A significant skewing of the peripheral T cell repertoire has been shown in relapsing-remitting multiple sclerosis (MS). Most of the studies already performed in this field are cross-sectional and therefore, little is known of the T cell repertoire evolution over time in MS and the correlation of T cell repertoire var...

journal_title：Journal of neuroimmunology

authors： Laplaud DA,Berthelot L,Miqueu P,Bourcier K,Moynard J,Oudinet Y,Guillet M,Ruiz C,Oden N,Brouard S,Guttmann CR,Weiner HL,Khoury SJ,Soulillou JP

更新日期：2006-08-01 00:00:00

abstract：:Bacterial meningitis is - despite therapeutical progress during the last decades - still characterized by high mortality and severe permanent neurogical sequelae. The brain is protected from penetrating pathogens by both the blood-brain barrier and the innate immune system. Invading pathogens are recognized by so-call...

journal_title：Journal of neuroimmunology

authors： Böhland M,Kress E,Stope MB,Pufe T,Tauber SC,Brandenburg LO

更新日期：2016-10-15 00:00:00

abstract：:Myelin-reactive T helper-17 cells are implicated in the pathogenesis of multiple sclerosis (MS). Here, we analyzed the reactivity of peripheral naive and memory conventional CD4(+)CD127(high) T cells (Tconv) of MS patients and healthy controls (HC) towards myelin basic protein (MBP), myelin oligodendrocyte glycoprotei...

journal_title：Journal of neuroimmunology

authors： Venken K,Hellings N,Hensen K,Rummens JL,Stinissen P

更新日期：2010-09-14 00:00:00

abstract：:Experimental autoimmune neuritis (EAN) is an animal model for Guillain-Barré syndrome (GBS). Intravenous immunoglobulins (IVIg) are an effective treatment for GBS, but their mechanism of action is not well understood. Here we tested whether IVIg treatment, a potent modulator of proinflammatory assaults, reduces inflam...

journal_title：Journal of neuroimmunology

authors： Enders U,Toyka KV,Hartung HP,Gold R

更新日期：1997-06-01 00:00:00

abstract：:To determine clinical features of neurologic disorders associated with anti-glutamic acid decarboxylase antibodies (anti-GAD-Ab), we examined titers and time-dependent changes of anti-GAD-Ab. Six patients, stiff person syndrome (2), cerebellar ataxia (1), limbic encephalitis (1), epilepsy (1), brainstem encephalitis (...

journal_title：Journal of neuroimmunology

authors： Nakajima H,Nakamura Y,Inaba Y,Tsutsumi C,Unoda K,Hosokawa T,Kimura F,Hanafusa T,Date M,Kitaoka H

更新日期：2018-04-15 00:00:00

abstract：:We previously reported that interleukin-4 (IL-4) inhibited proliferation of a human astrocytic cell line derived from non-neoplastic adult cortex. To determine whether this effect was receptor-associated and/or limited to only non-neoplastic astrocytes, we examined IL-4 responsiveness and receptor expression in human ...

journal_title：Journal of neuroimmunology

authors： Barna BP,Estes ML,Pettay J,Iwasaki K,Zhou P,Barnett GH

更新日期：1995-07-01 00:00:00

abstract：:CD4(+) T cells specific for the acetylcholine receptor (AChR) are assumed to play an important role in pathogenesis of myasthenia gravis (MG). A large and diverse number of potential T cell epitopes have been reported for different experimental setups aiming at the identification of disease-relevant T cells in MG. Inv...

journal_title：Journal of neuroimmunology

authors： Jung C,Stoeckle C,Wiesmüller KH,Laub R,Emmrich F,Jung G,Melms A

更新日期：2008-09-15 00:00:00

abstract：:In a series of 145 cases with neurological diseases, macrophage-colony stimulating factor (M-CSF) was detected in cerebrospinal fluid of patients with brain tumors, bacterial meningitis, and less frequently, AIDS-dementia complex. Granulocyte-colony stimulating factor (G-CSF) was found only in patients with bacterial ...

journal_title：Journal of neuroimmunology

authors： Gallo P,Pagni S,Giometto B,Piccinno MG,Bozza F,Argentiero V,Tavolato B

更新日期：1990-09-01 00:00:00

abstract：:Studies on patients with monosymptomatic optic neuritis (ON) should give opportunities to identify features typical for early multiple sclerosis (MS). There are increased T and B cell responses to the myelin components myelin basic protein (MBP) and proteolipid protein (PLP) in both ON and MS, but there is little info...

journal_title：Journal of neuroimmunology

authors： Link J,Söderström M,Kostulas V,Olsson T,Höjeberg B,Ljungdahl A,Link H

更新日期：1994-01-01 00:00:00

abstract：:This study aimed to evaluate the effects of leptin, ghrelin and neuropeptide-Y on the development of nonconvulsive seizure activity and their role on combating oxidative stress and cytokines produced by the systemic immune response in the WAG/Rij rat model for genetic absence epilepsy. Current study showed that all th...

journal_title：Journal of neuroimmunology

authors： Oztas B,Sahin D,Kir H,Kuskay S,Ates N

更新日期：2021-02-15 00:00:00

abstract：:Microglial cells in the healthy adult brain possess a characteristic ramified morphology with multiple branched processes, small somata and down-regulated inflammatory properties. In contrast, microglial cells isolated from new-born rat brain inevitably show a non-ramified amoeboid phenotype, which is observed in vivo...

journal_title：Journal of neuroimmunology

authors： Wollmer MA,Lucius R,Wilms H,Held-Feindt J,Sievers J,Mentlein R

更新日期：2001-04-02 00:00:00

abstract：:We established cultures of human astrocytes and astrocytoma cells from surgical specimens, to study regulation of class II major histocompatibility (MHC) complex antigen expression by interferons. Using these cultures we previously showed that expression of the class II MHC determinant HLA-DR could be induced by inter...

journal_title：Journal of neuroimmunology

authors： Ransohoff RM,Devajyothi C,Estes ML,Babcock G,Rudick RA,Frohman EM,Barna BP

更新日期：1991-08-01 00:00:00

abstract：:In order to evaluate changes in lymphocyte subpopulations of cerebrospinal fluid (CSF) cells in neurological diseases, normal control data have to be established. In this study we evaluated CSF samples from 65 dogs of both sexes and various breeds with an age range between 5 months and 6 years, and 20 one-year-old hea...

journal_title：Journal of neuroimmunology

authors： Tipold A,Moore P,Jungi TW,Sager H,Vandevelde M

更新日期：1998-02-01 00:00:00

abstract：:The key role of an inhibitory receptor, Programmed Death-1, has been evaluated in 273 patients with autoimmune myasthenia gravis. At the genetic level, SNP's genotyping showed no significant association to the disease. Gene expressions in patients were not different from that in controls. Interestingly, at the cell-su...

journal_title：Journal of neuroimmunology

authors： Sakthivel P,Ramanujam R,Wang XB,Pirskanen R,Lefvert AK

更新日期：2008-01-01 00:00:00

abstract：:IFN-gamma (IFN-gamma) has been shown to activate astrocytes to acquire immune functions. In this study the effect of IFN-gamma on murine astrocytes was investigated via microarray analysis. The activating effect of IFN-gamma on the astrocyte transcriptome showed predominance toward pathways involved in adaptive immuni...

journal_title：Journal of neuroimmunology

authors： Halonen SK,Woods T,McInnerney K,Weiss LM

更新日期：2006-06-01 00:00:00

abstract：:Antibody responses to myelin antigens were analysed in 15 patients who developed acute neuroparalytic accidents (ANPA) during post-exposure rabies vaccination using a rabies vaccine prepared on brain tissues and in 30 individuals who were uneventfully vaccinated. High titers (> or = 100) of IgG and IgM antibodies to G...

journal_title：Journal of neuroimmunology

authors： Laouini D,Kennou MF,Khoufi S,Dellagi K

更新日期：1998-11-02 00:00:00

abstract：BACKGROUND AND PURPOSE:The Toll-like receptor 4(TLR4)/nuclear factor kappa B NF-κB inflammatory pathway contributes to secondary inflammation in many diseases including stroke. Moreover, the neuroprotective effect of splenectomy in stroke is supported by a vast body of experimental evidence. Nevertheless, the underlyin...

journal_title：Journal of neuroimmunology

authors： Belinga VF,Wu GJ,Yan FL,Limbenga EA

更新日期：2016-04-15 00:00:00