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Low dose zymosan ameliorates both chronic and relapsing experimental autoimmune encephalomyelitis.

Abstract：

:Zymosan has previously been reported to have both pro-inflammatory and anti-inflammatory effects. Here we demonstrate that low dose zymosan prevented or reversed chronic and relapsing paralysis in EAE. In suppressing CNS autoimmune inflammation, zymosan not only regulated APC costimulator and MHC class II expression, but also promoted differentiation of regulatory T cells. Following adoptive transfer of zymosan-primed CD4(+) T cells, recipient mice were protected from EAE. In contrast, a MAPK inhibitor and a blocker of β-glucan, reversed the effects of zymosan. These results demonstrate that zymosan may be a promising beneficial agent for Multiple Sclerosis (MS).

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Li H,Gonnella P,Safavi F,Vessal G,Nourbakhsh B,Zhou F,Zhang GX,Rostami A

doi

10.1016/j.jneuroim.2012.08.013

subject

Has Abstract

pub_date

2013-01-15 00:00:00

pages

28-38

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(12)00271-8

journal_volume

254

pub_type

杂志文章

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