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Alterations in circulating T cell functional subpopulations in interferon-beta treated multiple sclerosis patients: A pilot study.

Abstract：

:Our work consists of a pilot study to characterize circulating Th/c1, Th/c2, Th/c17, Treg and Tfh-like populations and IL-17 serum levels of relapsing-remitting (RR) MS patients treated with IFN-β, compared with healthy controls. In remission RRMS patients, we observe increased Th/c17 cells frequency committed to a Th1 profile and increased soluble IL-17 levels. Moreover, a shift toward Th/c2 with reduction of Tc1 cells and decrease in effector/terminal differentiated compartment of Th1 cells were also observed. Despite RRMS patients being an inactive disease phase, IL-17 and Th/c17 cells seemed to contribute to perpetuating chronic inflammation, besides the altered ratio Th1/Th2.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Monteiro A,Rosado P,Rosado L,Fonseca AM,Paiva A

doi

10.1016/j.jneuroim.2019.577113

subject

Has Abstract

pub_date

2020-02-15 00:00:00

pages

577113

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(19)30269-3

journal_volume

339

pub_type

杂志文章

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